| Project/Area Number |
21592448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
|
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| Research Institution | Okayama University |
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Principal Investigator |
HARA Tetsuya 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60238160)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Tohru 就実大学, 薬学部, 教授 (30243463)
KODAMA Chie 岡山大学, 医歯薬学総合研究科, 助教 (50444667)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KAWATA Kazumi 岡山大学, 歯学部, 非常勤研究員 (10457228)
MINAGI Shogo 岡山大学, 医歯薬学総合研究科, 教授 (80190693)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 咀嚼 / 記憶 / 海馬 / 認知症 / 遺伝子 / DNAアレイ / 歯 / ラット / マイクロアレイ |
|---|
| Research Abstract |
The memory related gene expression in the rat hippocampus was analyzed by using the DNA microarray method. The gene expression of Trh and Tnxa increased when studying, and that of Nnat and S100a9 decreased. The number of errors of radial maze in the extraction group was more than that of the denture group and the control group. The time course of these 4 gene expression was observed by real-time PCR method. The gene expression of Tnxa Nnat and S100a9 showed the consistency with behavioral experiment result.
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