Prevention of dementia by the recovery of the mastication

• Project/Area Number: 21592448
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Okayama University
• Principal Investigator: HARA Tetsuya 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60238160)
• Co-Investigator(Kenkyū-buntansha): NAKANISHI Tohru 就実大学, 薬学部, 教授 (30243463) ; KODAMA Chie 岡山大学, 医歯薬学総合研究科, 助教 (50444667)
• Co-Investigator(Renkei-kenkyūsha): KAWATA Kazumi 岡山大学, 歯学部, 非常勤研究員 (10457228) ; MINAGI Shogo 岡山大学, 医歯薬学総合研究科, 教授 (80190693)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 咀嚼 / 記憶 / 海馬 / 認知症 / 遺伝子 / DNAアレイ / 歯 / ラット / マイクロアレイ

Research Abstract

The memory related gene expression in the rat hippocampus was analyzed by using the DNA microarray method. The gene expression of Trh and Tnxa increased when studying, and that of Nnat and S100a9 decreased. The number of errors of radial maze in the extraction group was more than that of the denture group and the control group. The time course of these 4 gene expression was observed by real-time PCR method. The gene expression of Tnxa Nnat and S100a9 showed the consistency with behavioral experiment result.

Research Products

• [Presentation] Memory-related gene expression in the rat hippocampus by the learning (2012)
  • Author(s): Iida S, Araki D, Hara T, Kuroda C, Oka M, Kurozumi A, Kawata K, Sakamoto S, Miyazaki T, Minagi S
  • Organizer: American Association for Dental Research
  • Place of Presentation: Tampa, USA
  • Year and Date: 2012-03-22
• [Presentation] 咬合支持回復時の空間認知能に対する分散学習の影響 (2011)
  • Author(s): 原哲也, 黒住明正, 坂本隼一, 飯田祥与, 荒木大介, 黒田知沙, 岡森彦, 白井肇, 森慎吾, 衣田圭宏, 皆木省吾
  • Organizer: 日本老年歯科医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-15
• [Presentation] Spaced Training Facilitates Long-term Memory Retention in Molarless Rats (2011)
  • Author(s): Hara T, Kurozumi A, Sakamoto S, Kuroda C, Oka M, Iida S, Araki D, Minagi S
  • Organizer: International Association for Dental Research
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-03-20
• [Presentation] Influence of Molar Loss on Gene Expression in Hippocampus (2010)
  • Author(s): Hara T, Kawata K, Kurozumi A, Oka M, Kuroda C, Shimazu-Kodama C, Sakamoto S, Minagi S
  • Organizer: International Association for Dental Research
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-17