| Project/Area Number |
21592491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Kazuto 東京大学, 医学部・附属病院, 特任准教授 (30344451)
IINO Mitsuyoshi 山形大学, 医学部・附属病院, 教授 (50212717)
CHIKAZU Daichi 東京医科大学, 医学部・附属病院, 教授 (30343122)
FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKATO Tsuyoshi 東京大学, 医学部・附属病院, 教授 (90171454)
MASUTANI Mitsuko 国立がん研究センター研究所, ゲノム安定性研究分野, 分野長 (60238904)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生歯学 / ポリADP-リボシル化反応 / 再生医療 / ノックアウトマウス / ポリADP-リボシル化 / 象牙芽細胞 / 歯髄 / ポリADP-リボース合成酵素 |
|---|
| Research Abstract |
In this report, Parp-1 was suggested to involve in odontoblast/osteoblast differentiation from mesenchymal stem cell(MSC) and factors related to morphology preservation. Through the time course analysis of mice teeth, dysplasia and malformation inside the teeth were found based on the two factors. Parp-1 deficiency and aging. In vitro differentiation inducement from MSCs, odontoblast and osteoblast differentiation was not observed under the inhibition of Parp activity.
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