Developments of scaffolds and processing technology to maximize the osteogenic potential of cultured periosteal sheets
| Project/Area Number |
21592492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUDA Kazuhiro 新潟大学, 医歯学系, 准教授 (00169228)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 培養骨膜シート / 骨再生 / 細胞基材 / 細胞プロセッシング |
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| Research Abstract |
We aimed to develop the fast processing methodology and novel scaffolds for human periosteal sheets. In general, scaffolds made of synthetic biodegradable polymers are not suitable for cell adhesion. However, our porous PLLA scaffold was capable of well securing periosteal sheets. This scaffold also functioned to facilitate extracellular matrices and cell penetration into deep pore regions. In this project, we have successfully developed several promising scaffolds with biodegradable polymermaterials.
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Report
(4 results)
Research Products
(100 results)
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[Journal Article] A short-term preservation of human cultured periosteal sheets, osteogenic grafting materials, using a comer-cial preservation solution containing epigallocatechin-3-gallate(Thelio-keepR) under chilled conditions2012
Author(s)
Kamiya M, Kawase T, Kobayashi M, Sekine Y, Okuda K, Nagata M, Fuse I, Nakata K, Wolff LF, Yoshie H
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Journal Title
Biopreserv Biobank
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] A clinical study of the alveolar bone tissue engineering with cultured autogenous periosteal cells : coordinated activation of bone forma-tion and resorption2012
Author(s)
Nagata M, Hoshina H, Li M, Arasawa M, Uematsu K, Ogawa S, Yamada K, Kawase T, Suzuki K, Ogose A, Amizuka N, Fuse I, Okuda K, Uoshima K, Nakata K, Yoshie H, Takagi R
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Journal Title
Bone
Volume: 50(5)
Pages: 1123-1129
Related Report
Peer Reviewed
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[Journal Article] A clinical study of the alveolar bone tissue engineering with cultured autogenous periosteal cells : coordinated activation of bone formation and resorption2012
Author(s)
Nagata M, Hoshina H, Li M, Arasawa M, Uematsu K, Ogawa S, Yamada K, Kawase T, Suzuki K, Ogose A, Amizuka N, Fuse I, Okuda K, Uoshima K, Nakata K, Yoshie H, Takagi R
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Journal Title
Bone
Volume: 50
Pages: 1123-1129
Related Report
Peer Reviewed
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[Journal Article] A short-term preservation of human cultured periosteal sheets, osteogenic grafting materials, using a commercial preservation solution containing epigallocatechin-3-gallate (Theliokeep^[○!R]) under chilled conditions2012
Author(s)
Kamiya M, Kawase T, Kobayashi M, Sekine Y, Okuda K, Nagata M, Fuse I, Nakata K, Wolff LF, Yoshie H
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Journal Title
Biopreserv Biobank
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] An osteogenic grafting complex composed of human periosteal sheet and its scaffolding material, a porous poly(L-lactic acid) membrane : biocompatibility, biodegradation, and cell fate in vivo2011
Author(s)
Kawase T, Tanaka T, Nishimoto T, Okuda K, Nagata M, Burns DM, Yoshie H
Organizer
Tissue Eng Regen Med Int Soc-Asia Pacific Chap 2011
Place of Presentation
Singapore, Singapore
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