Regulation of periodontal tissue re-generation with combination use of FGF-2 and on-demand 3D shaped graft material

• Project/Area Number: 21592495
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka University
• Principal Investigator: NOZAKI Takenori 大阪大学, 大学院・歯学研究科, 助教 (30263304)
• Co-Investigator(Kenkyū-buntansha): KITAMURA Masahiro 大阪大学, 大学院・歯学研究科, 准教授 (10243247) ; SAHO Teruyuki 大阪大学, 歯学部附属病院, 助教 (10263295)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 組織再生 / シグナル分子 / インプラント / FGF-2 / 再生歯学 / 三次元培養

Research Abstract

It is confirmed that the combination use of FGF-2 and beta-TCP has a significant potential to promote periodontal tissue regeneration in an animal model study. Additionally, it is revealed that FGF-2 promotes osteogenesis and initial osseo-integration of implant with low primary stability. These results suggest that FGF-2 is a Signaling molecule suitable for on-demand 3D shaped transplant material which promotes tissue regeneration effectively

Research Products

• [Journal Article] Effects of concomitant use of fibroblast growth factor(FGF)-2 with betatricalcium phosphate(β-TCP) on the beagle dog 1-wall periodontal defect model (2010)
  • Author(s): Anzai J, Kitamura M, Nozaki T, Nagayasu T, Terashima A, Asano T, Murakami S
  • Journal Title: Biochem Biophys Res Commun Volume: 403巻 Pages: 345-350
  • Peer Reviewed
• [Journal Article] Effects of concomitant use of fibroblast growth factor (FGF)-2 with beta-tricalcium phosphate (β-TCP) on the beagle dog 1-wall periodontal defect model. (2010)
  • Author(s): Anzai J, Kitamura M, Nozaki T, 他4名
  • Journal Title: Biochem Biophys Res Commun. Volume: 403 Pages: 345-350
  • Peer Reviewed
• [Presentation] Effects of a Combination of Beta-tricalcium Phosphate and Fibroblast Growth Factor(FGF)-2 on Periodontal Regeneration in the One-wall Intrabony Defect Model in Dogs (2011)
  • Author(s): Hanaki N, Nozaki T, Dziak R, Cho M, Murakami S, Genco R
  • Organizer: 第97回米国歯周病学会
  • Place of Presentation: 米国フロリダ州マイアミビーチコンベンションセンター
  • Year and Date: 2011-11-13
• [Presentation] Effects of a Combination of Beta-tricalcium Phosphate and Fibroblast Growth Factor (FGF)-2 on Periodontal Regeneration in the One-wall Intrabony Defect Model in Dogs (2011)
  • Author(s): N.Hanaki, T.Nozaki, et.al.
  • Organizer: 第97回米国歯周病学会
  • Place of Presentation: 米国フロリダ州マイアミビーチコンベンションセンター
  • Year and Date: 2011-11-13
• [Presentation] 初期固定不良インプラントモデルを用いたFGF-2のオッセオインテグレーション促進効果の検討 (2011)
  • Author(s): 野崎剛徳、市川朋生、寺倉まみ、岩山智明、大原廣之、粟田敏仁、松本航、安齋純、永安利江、高木崇、寺嶋昭夫、北村正博、村上伸也
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 山口県下関市海峡メッセ下関
  • Year and Date: 2011-09-24
• [Presentation] FGF-2により誘導される血管新生へのマウス歯根膜細胞の関与 (2011)
  • Author(s): 兒嶋由子、柳田学、森健太、野崎剛徳、山田聡、北村正博、村上伸也
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 福岡県福岡市福岡国際会議場
  • Year and Date: 2011-05-28