Establishment of application criteria of maxillomandibular advancement surgery in Japanese patients with sleep apnea syndrome

• Project/Area Number: 21592518
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: SAITO Chikara 新潟大学, 医歯学系, 教授 (80103357)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Tadaharu 新潟大学, 医歯学総合病院, 講師 (80195792) ; TAKATA Yoshiyuki 新潟大学, 医歯学系, 助教 (40313548) ; IZUMI Naoya 新潟大学, 医歯学総合病院, 助教 (10361908)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 睡眠時無呼吸症候群 / 上下顎前方移動術 / 顎骨形態 / 気道形態 / 睡眠検査 / 上下顎骨前方移動術 / 終夜睡眠ポリソムノグラフィ / 睡眠時呼吸状態

Research Abstract

Pharyngeal airway volume was decreased significantly after mandibular set back surgery in patients with mandibular protrusion, but apnea-hypopnea index was not changed significantly after surgery. Oral appliance therapy for obstructive sleep apnea syndrome is more effective in patients with large anteroposterior diameter of the maxilla and large lower facial height. These data linking maxillofacial morphology to respiratory function during sleep are useful to establish the application criteria of maxillomandibular advancement surgery in Japanese patients with sleep apnea syndrome.

Research Products

• [Journal Article] Changes in overnight arterial oxygen saturation following mandibular setback surgery (2013)
  • Author(s): Tadaharu Kobayashi, Akinori Funayama, Daichi Hasebe, Yusuke Kato, Michiko Yoshizawa, Chikara Saito
  • Journal Title: Br. J. Oral Maxillofac. Surg Volume: 51 Pages: 312-318
  • URL: http://dx.doi.org/10.1016/j.bjoms.2012.07.004
  • Peer Reviewed
• [Journal Article] Prognostic predictors on the efficacy of oral appliance therapy for obstructive sleep apnea syndrome (2012)
  • Author(s): Tadashi Iwamoto, Yoshiyuki Takata, Nobutaka Kitamura, Daichi Hasebe, Tadaharu Kobayashi, Chikara Saito
  • Journal Title: Open Journal of Stomatology Volume: 2 Issue: 03 Pages: 210-221
  • DOI: 10.4236/ojst.2012.23038
  • Peer Reviewed
• [Journal Article] Changes in overnight arterial oxygen saturation following mandibular setback surgery. (2012)
  • Author(s): Kobayashi T, Funayama A, Hasebe D, Kato Y, Yoshizawa M, Saito C
  • Journal Title: Br. J. Oral Maxillofac. Surg, Volume: available online Issue: 4 Pages: 312-318
  • DOI: 10.1016/j.bjoms.2012.07.004
  • Peer Reviewed
• [Journal Article] Changes in oropharyngeal airway and respiratory function during sleep after orthognathic surgery in patients with mandibular prognathism (2011)
  • Author(s): aichi Hasebe, Tadaharu Kobayashi, Mayumi Hasegawa, Tadashi Iwamoto, Kensuke Kato, Naoya Izumi, Yoshiyuki Takata, Chikara Saito
  • Journal Title: Int J Oral Maxillofac Surg Volume: 40(6) Pages: 584-92
  • URL: http://dx.doi.org/10.1016/j.ijom.2011.01.011
  • Peer Reviewed
• [Journal Article] Changes in oropharyngeal airway and respiratory function during sleep after orthognathic surgery in patients with mandibular prognathism (2011)
  • Author(s): Hasebe D, Kobayashi T, Hasegawa M, Iwamoto T, Kato K, Izumi N, Takata Y, Saito C
  • Journal Title: Int J Oral Maxillofac Surg Volume: 40(6) Issue: 6 Pages: 584-592
  • DOI: 10.1016/j.ijom.2011.01.011
  • Peer Reviewed
• [Journal Article] Relationship between severity of sleep-disordered breathing and craniofacial morphology in Japanese male patients (2009)
  • Author(s): Keishi Ishiguro, Tadaharu Kobayashi,Nobuo Kitamura, Chikara Saito
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology Volume: 107(3) Issue: 3 Pages: 343-349
  • DOI: 10.1016/j.tripleo.2008.08.021
  • Peer Reviewed
• [Journal Article] Changes in oropharyngeal airway and respiratory function during sleep afterorthognathic surgery in patients with mandibulaz prognathism.
  • Author(s): Hasebe D, Kobayashi T, Hasegawa M, Iwamoto T, Kato K, Izumi N, TakataY, Saito C.
  • Journal Title: Int J Oral Maxillofac Surg. Volume: In Press(published online 2 March 2011)
  • Peer Reviewed
• [Presentation] 顎矯正手術が咽頭気道形態と睡眠時の呼吸機能に及ぼす影響について (2012)
  • Author(s): 上杉崇史、小林正治、長谷部大地、田中礼、池真樹子、齊藤力
  • Organizer: 平成24年度新潟歯学会第二回例会
  • Place of Presentation: 新潟
  • Year and Date: 2012-11-10
• [Presentation] 閉塞型睡眠呼吸障害に対する口腔内装置の治療効果 (2012)
  • Author(s): 上杉崇史、小林正治、高田佳之、泉直也、長谷部大地、齊藤力
  • Organizer: 平成24年度新潟歯学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2012-04-21
• [Presentation] 閉塞型睡眠呼吸障害に対する口腔内装置の治療効果 (2012)
  • Author(s): 上杉崇史、小林正治、高田佳之、泉 直也、長谷部大地、齊藤 力
  • Organizer: 平成24年度新潟歯学会総会
  • Place of Presentation: 新潟大学（新潟市）
• [Presentation] 新潟大学医歯学総合病院口腔外科いびき外来における過去10年間の臨床統計的検討 (2012)
  • Author(s): 上杉崇史、小林正治、高田佳之、泉 直也、長谷部大地、齊藤 力
  • Organizer: 日本睡眠学会第37回定期学術集会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] 顎矯正手術が咽頭気道形態と睡眠時の呼吸機能に及ぼす影響について (2012)
  • Author(s): 上杉崇史、小林正治、長谷部大地、田中 礼、池真樹子、齊藤 力
  • Organizer: 平成24年度新潟歯学会第二回例会
  • Place of Presentation: 新潟大学（新潟市）
• [Presentation] 日本人男性における閉塞型睡眠時無呼吸症候群のリスクファクター (2011)
  • Author(s): 長谷部大地,小林正治,上杉崇史,小田陽平,泉直也,高田佳之,齊藤力
  • Organizer: 日本睡眠学会第36回定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-10-15
• [Presentation] 日本人における閉塞型睡眠時無呼吸症候群のリスクファクター (2011)
  • Author(s): 長谷部大地、小林正治、上杉崇史、小田陽平、泉直也、高田佳之、齊藤力
  • Organizer: 日本睡眠学会第36回定期学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] 下顎骨前方移動術が気道形態と睡眠時の呼吸状態に及ぼす影響について (2010)
  • Author(s): 長谷部大地、小林正治、泉直也、高田佳之、齊藤力
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2010-07-20
• [Presentation] 骨格性下顎前突症患者に対する顎矯正手術が睡眠時血中酸素飽和度に及ぼす影響 (2010)
  • Author(s): 小林正治、長谷部大地、泉直也、高田佳之、芳澤享子、齊藤力
  • Organizer: 第20回特定非営利活動法人日本顎変形症学会総会
  • Place of Presentation: 札幌プリンスホテル国際館パミール
  • Year and Date: 2010-06-16
• [Presentation] 骨格性下顎前突症患者に対する顎矯正手術が睡眠時血中酸素飽和度に及ぼす影響 (2010)
  • Author(s): 小林正治、長谷部大地、泉直也、高田佳之、芳澤享子、齊藤力
  • Organizer: 第20回日本顎変形症学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-05
• [Presentation] 下顎骨前方移動術が気道形態と睡眠時の呼吸状態に及ぼす影響について (2010)
  • Author(s): 長谷部大地、小林正治、泉直也、高田佳之、齊藤力
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
• [Presentation] 下顎骨後方移動術が気道形態と睡眠時の呼吸状態に及ぼす影響について (2009)
  • Author(s): 長谷部大地、小林正治、長谷川真弓、岩本忠士、加藤健介、泉直也、高田佳之、齊藤力
  • Organizer: 第6回アジア睡眠学会・日本睡眠学会第34回定期学術集会・第16回日本時間生物学会学術大会合同大会
  • Place of Presentation: 大阪