Testing the utility of rationally engineered recombinant collagen-like proteins for applications of bone regeneration with bone morphogenetic protein in tissue engineering.
| Project/Area Number |
21592520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Kenji 名古屋大学, 医学部附属病院, 助教 (50402623)
KINOSHITA Kazuhiko 名古屋大学, 医学部附属病院, 医員 (40467296)
UEDA Minoru 名古屋大学, 大学院・医学系研究科, 教授 (00151803)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | リコンビナント / cDNAカセット / コラーゲン / 骨形成蛋白(BMP) / 骨再生 / スキャフォールド / 異所性骨化 |
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| Research Abstract |
We mapped the D4 domain of human collagen I as most critical for binding site of bone morphogenetic protein(BMP) and used this information to genetically engineer a collagen-like protein consisting of tandem repeats of the D4 domain(mD4 collagen). We proved recombinant human mD4 collagen-like protein had a potential for an efficient scaffold as same as other scaffolds materials for engineering of bone when combined with BMP.
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Report
(4 results)
Research Products
(11 results)
