Effects of Visible Light-irradiated Phenolic Antioxidant Compounds on Cancer Cells
| Project/Area Number |
21592537
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Meikai University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 癌細胞 / 抗酸化剤 / 光照射 / フェノール / photodynamic therapy |
|---|
| Research Abstract |
Visible light(VL) irradiation effects of the mucous membranes of mice treated with curcumin(chief ingredient of the curry powder) and capsaicin(chief ingredient of the red pepper) were investigated. It was found that inflammation and apoptosis were caused by the VL treatment of both compounds, particularly the latter could kill cancer cells. In addition, curcumin and capsaicin could accelerate the cytostasis action of the human squamous cell carcinoma cells at more low concentrations in combination with VL irradiation. This suggested a possibility to the clinical application of the photodynamic therapy of curcumin due to the potent apoptotic activity of this compound.
|
Report
(4 results)
Research Products
(1 results)
