| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
It aimed at the elucidation of a molecule background(an expression pattern, an activation mechanism) and pathological significance under considering the medical treatment strategy which made Aurora the target. Establishment of stable expression of each Aurora protein that fused GFP in squamous cell carcinoma cell line was tried, and it succeeded in visualizing the intracellular dynamic state of each Aurora in real time by using of a confocal laser scanning microscope. A possibility that Aurora was an effective molecule target was shown.
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