Linkage analysis between intraoral circumstances and obesity involved by adipokines in patients of Down syndrome
| Project/Area Number |
21592599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NONAKA Kazuaki (MASUDA Keiji) 九州大学, 大学病院, 講師 (60392122)
中村 由紀 九州大学, 歯学研究院, 助教 (70452779)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | ダウン症 / 肥満 / アディポネクチン / 口腔内環境 / 鶴蝕 / 歯周疾患 / 唾液 / 齲蝕 / トリソミー / 歯石 / IgA / 齲蝕リスク / アディポサイトカイン / 歯周病 / 口腔粘膜疾患 / 歯垢 |
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| Research Abstract |
In this study, we carried out the oral examination and several tests for 30 outpatients of Down syndrome who obtained informed consents in our University Hospital. All of them were very poor in their oral hygiene, and 28 patients clearly showed gingivitis. The salivary buffering capacity of them was low. As a result with the analysis of salivary pH and mineral components, the values of Na^<+> and K^(+) in Down' s patients were higher than them in normal ones, though they were not statistically significant. Moreover, salivary adiponectin levels in Down' s patients were not significant compared with them in normal ones. Actually, in our study, we could not get a significant relationship between adiponectin and Down syndrome. However, we need to make clear whether obesity in Down syndrome might affect for an occurrence and progression of oral diseases.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Expression levels of adiponectin receptors and periodontitis2010
Author(s)
Yamaguchi, N., T. Hamachi, N. Kamio, S. Akifusa, K. Masuda, Y. Nakamura, K. Nonaka, K. Maeda, S. Hanazawa, and Y. Yamashita.
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Journal Title
J. Periodont. Res
Volume: 45
Pages: 296-300
Related Report
Peer Reviewed
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[Journal Article] adiponectininduced RAW264 apoptosis is regulated by reactive oxygen species-dependent pathway involving Bcl-22009
Author(s)
Akifusa, S., Kamio, N., Shimazaki, Y., Yamaguchi, N., Nishihara, T., and Yamashita, Y. Globular
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Journal Title
FreeRadioc. Biol. Med
Volume: 46(9)
Pages: 1308-1316
Related Report
Peer Reviewed
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[Journal Article] Prevalence of natal/neonatal teeth incleft lip and palate infants2009
Author(s)
Iwamoto, T., Yoshizaki, K., Sonoda, A., Nakamura, Y., Matsuishi, Y., Yamaguchi, N., and Nonaka, K.
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Journal Title
Ped. Dent. J
Volume: 19(1)
Pages: 46-51
Related Report
Peer Reviewed
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[Journal Article] Prevalence of natal/neonatal teeth in cleft lip and palate infants2009
Author(s)
Iwamoto, T., Yoshizaki, K., Sonoda, A., Nakamura, Y., Matsuishi, Y.Yamaguchi, N., Nonaka, K
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Journal Title
Ped.Dent.J. 19(1)
Pages: 46-51
NAID
Related Report
Peer Reviewed
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[Journal Article] SOCS-3 inhibits E2F/DP-1 transcriptional activity and cell-cycle progression via interaction with DP-12008
Author(s)
Masuhiro, Y., Kayama K., Fukushima, A., Baba, K., Soutsu, M., Kamiya, Y., Gotoh, M., Yamaguchi, N., and Hanazawa, S.
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Journal Title
J Biol Chem
Volume: 283(46)
Pages: 31575-31583
Related Report
Peer Reviewed
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[Journal Article] The relationship between periodontal condition and serum levels of resistin andadiponectin in elderly Japanese2008
Author(s)
Furugen, R., Hayashida, H., Yamaguchi, N., Yoshihara, A., Ogawa, H., Miyazaki, H., and Saito, T.
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Journal Title
J. Periodont. Res
Volume: 43
Pages: 556-562
Related Report
Peer Reviewed
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