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Determine the novel amelogenin receptor which influence bone formation

Research Project

Project/Area Number 21592605
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

KONISHI Ikuri (2010-2011)  長崎大学, 病院, 客員研究員 (00572380)

齋藤 幹 (2009)  Nagasaki University, 病院, 助教 (40380852)

Co-Investigator(Kenkyū-buntansha) HOSHINO Tomonori  長崎大学, 病院, 講師 (00359960)
NISHIGUCHI Miyuki  長崎大学, 大学院医歯薬学総合研究科, 助教 (10253676)
HIDAKA Kiyoshi  長崎大学, 大学院医歯薬学総合研究科, 助教 (10389421)
FUJIWARA Taku  長崎大学, 大学院医歯薬学総合研究科, 助教 (00228975)
SATOU Kyouko  長崎大学, 病院, 助教 (70404499)
小西 郁里  長崎大学, 病院, 助教 (00572380)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsアメロジェニン / 骨芽細胞 / 骨形成 / 受容体 / 骨代謝 / 細胞内シグナル / エナメルマトリックス
Research Abstract

Amelogenin stimulated about 23 kinds transcription factors in osteoblast. These transcription factors were analyzed by in silico data mining. This result was speculated that Amelogenin signaling pathways were ERK signal, Wnt/β-catenin signal and TGF-βBMP/ Smad signal. To confirm this result, it was inspected by a phosphorylation antibody whether Amelogenin through these signals in osteoblast or not.
Smad2/ 3/ 5 did not effect but ERK andβ-catenin were activated by amelogenin. Thus, it is suggested that novel amelogenin receptor not involving LAMP1 and CD63 may be Frizzled families which were a Wnt receptor.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2009

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] アメロジェニンによる骨代謝への影響2009

    • Author(s)
      斎藤幹
    • Journal Title

      小児歯科学雑誌 47巻

      Pages: 555-560

    • NAID

      10027488528

    • Related Report
      2009 Annual Research Report
  • [Presentation] アメロジェニンによる骨代謝への影響2009

    • Author(s)
      斎藤幹
    • Organizer
      日本小児歯科学会
    • Place of Presentation
      大阪大学コンベンションセンター(大阪府)
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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