Study of bone remodeling using mouse teeth movement model
| Project/Area Number |
21592611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
FUKAI Naomi 奥羽大学, 歯学部, 教授 (60134681)
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| Co-Investigator(Kenkyū-buntansha) |
MORO Yuriko 奥羽大学, 歯学部, 助教 (90433549)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMATO Masayuki 東京女子医科大学, 医学部, 教授 (40711726)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 歯科矯正学 / 骨リモデリング / マウス / 器官培養 / メカニカルストレス / 骨 / リモデリング / I型コラーゲン / エストロジェン受容体 |
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| Research Abstract |
The mechanism of bone remodeling was studied using organ culture system in which mechanical force was given to a molar of mouse maxilla. Before an actual tooth movement was observed expression of col1 and estrogen receptor RNAs were changed just after a couple of hours after the stress was given. These results indicated that early molecular changes occurred and affected the bone remodeling.
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Report
(4 results)
Research Products
(12 results)
