Study of bone remodeling using mouse teeth movement model

• Project/Area Number: 21592611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Ohu University
• Principal Investigator: FUKAI Naomi 奥羽大学, 歯学部, 教授 (60134681)
• Co-Investigator(Kenkyū-buntansha): MORO Yuriko 奥羽大学, 歯学部, 助教 (90433549)
• Co-Investigator(Renkei-kenkyūsha): YAMATO Masayuki 東京女子医科大学, 医学部, 教授 (40711726)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 歯科矯正学 / 骨リモデリング / マウス / 器官培養 / メカニカルストレス / 骨 / リモデリング / I型コラーゲン / エストロジェン受容体

Research Abstract

The mechanism of bone remodeling was studied using organ culture system in which mechanical force was given to a molar of mouse maxilla. Before an actual tooth movement was observed expression of col1 and estrogen receptor RNAs were changed just after a couple of hours after the stress was given. These results indicated that early molecular changes occurred and affected the bone remodeling.

Research Products

• [Presentation] マウスの歯を動かして解ること (2011)
  • Author(s): 深井直実
  • Organizer: バイオイメージング学・特別セミナー
  • Place of Presentation: 香川大学・医学部
  • Year and Date: 2011-02-01
• [Presentation] マウスの歯を動かして解る事 (2011)
  • Author(s): 深井直実
  • Organizer: バイオイメージング特別セミナー
  • Place of Presentation: 香川
• [Presentation] マウスの歯を動かしてわかること (2010)
  • Author(s): 深井直実
  • Organizer: 第34回「峠の会」形態学シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2010-07-31
• [Presentation] マウスの歯を動かしてわかること (2010)
  • Author(s): 深井直実
  • Organizer: 第34回峠の会形態学シンポジウム
  • Place of Presentation: 新潟
• [Remarks]
  • URL: http://www.ohu-u.ac.jp/faculty/research/researchD2.html
• [Remarks]
  • URL: http://shingakunet.com/net/sensei/detail/SC000179/900027619
• [Remarks]
  • URL: http://www.ohu-u.ac.jp/faculty/research/researchD2.html
• [Remarks]
  • URL: http://shingakunet.com/net/sensei/detail/SC000179/9000276195
• [Remarks]
  • URL: http://www.ohu-u.ac.jp/faculty/research/researchD2.html
• [Remarks]
  • URL: http://shingakunet.com/net/sensei/detail/SC000179/9000276195
• [Remarks]
  • URL: http://www.ohu-u.ac.jp/faculty/research/researchD2.html
• [Remarks]
  • URL: http://shingakunet.com/net/sensei/detail/SC000179/9000276195