| Project/Area Number |
21592664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Kenichi 日本大学, 歯学部, 講師 (60381810)
OCHIAI Kuniyasu 日本大学, 歯学部, 教授 (50095444)
YAMADA Kiyoshi 日本大学, 歯学部, 助教 (30313076)
SENPUKU Hidenobu 国立感染症研究所, 技官 (20250186)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 口腔ケア / 医療・福祉 / 衛生 / 歯学 / 口腔微生物 / 老化 / カテキン / 老化微生物 |
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| Research Abstract |
Microbial inhibition zones against oral microorganisms using gel-entrapped catechin(GEC) were found for all of the strains of Actinomyces naeslundii, Streptococcus mutans, Candida albicans and periodontopathic bacteria in vitro assay. By contrast, no inhibitory effect was observed for oral streptococci which play an important role in indigenous oral flora. The anti-microbial activity of GEC is related with hydrogen peroxide. On the other hand, in vivo assay, same anti-microbial activity was observed by the application of GEC.
These results suggest that GEC could be useful for oral care in the elderly.
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