| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Polarity and origins of macrophages and microglia in peripheral nerves, dorsal root ganglia(DRG) and dorsal horns were examined in Seltzer model mice. In injured sciatic nerves, the number of M1 macrophages got its peak at 3days after surgery. Most of these macrophages were shown to be derived from the bone marrow. After 3～7 days. M2 macrophages and M1 microglia were increased in the DRG and dorsal horns. respectively. These cells were considered to be resident, since EGFP positive macrophages and microglia were first detected at 3 weeks after surgery.
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