2011 Fiscal Year Final Research Report
The involvement of CCL3, CCR5 in inflammatory and neuropathic pain
| Project/Area Number |
21600011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
SENBA Emiko 和歌山県立医科大学, 医学部, 教授 (00135691)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経障害性疼痛 / Seltzerモデル / macrophage / microglia / 極性 / 骨髄移植 / DRG / 脊髄後角 |
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| Research Abstract |
Polarity and origins of macrophages and microglia in peripheral nerves, dorsal root ganglia(DRG) and dorsal horns were examined in Seltzer model mice. In injured sciatic nerves, the number of M1 macrophages got its peak at 3days after surgery. Most of these macrophages were shown to be derived from the bone marrow. After 3～7 days. M2 macrophages and M1 microglia were increased in the DRG and dorsal horns. respectively. These cells were considered to be resident, since EGFP positive macrophages and microglia were first detected at 3 weeks after surgery.
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[Journal Article] Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain like state usinf fMRI and brain wave analysis2011
Author(s)
Takemura Y, Yamashita A, Horiuchi H, Furuya M, Yanase M, Niikura K, Imai S, Hatakeyama N, Kinoshita H, Tsukiyama Y, Senba E, Matoba M, Kuzumaki N, Yamazaki M, Suzuki T, Narita M
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Journal Title
Synapse
Volume: 65(7)
Pages: 668-676
Peer Reviewed
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