Development of the gene therapy against the morphine-resistant intractable pain using endomorphin precursor
| Project/Area Number |
21600013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKURADA Shinobu 東北薬科大学, 薬学部, 教授 (30075816)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エンドモルフィン / 産生遺伝子 / 難治性疼痛 / ジーンセラピー / μ受容体 |
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| Research Abstract |
We found the DNA fragments which theoretically can synthesize endomorphin-1(EM-1) and endomorphin-2(EM-2). The reduction of this DNA fragment, observed in a neuropathic pain state, revealed the reduction of pain threshold. On the other hand, unlike morphine, EM-1 and EM-2 showed potent analgesic effect against neuropathic pain. Moreover, theμ-opioid receptor splice variants sensitive to EM-1 and EM-2 retained in a neuropathic pain state. The results provide the information for the development of the gene therapy against the morphine-resistant intractable pain using endomorphin precursor.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine2011
Author(s)
H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
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Journal Title
Neurosci. Lett
Volume: 495
Issue: 2
Pages: 83-87
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally2011
Author(s)
H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
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Journal Title
Eur. J. Pharmacol
Volume: 653
Issue: 1-3
Pages: 21-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Lack of a rewarding effect and a locomotor-enhancing effect of the selectiveμ-opioid receptor agonist amidino-TAPA2010
Author(s)
H. Mizoguchi, C. Watanabe, S. Osada, M. Yoshioka, Y. Aoki, S. Natsui, A. Yonezawa, S. Kanno, M. Ishikawa, T. Sakurada, S. Sakurada
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Journal Title
Psychopharmacology
Volume: 212
Issue: 2
Pages: 215-225
DOI
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
溝口広一
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Journal Title
生体の科学60((財)金原一郎記念医学医療振興財団/医学書院)
Pages: 448-449
Related Report
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