Development of Inhibitors for Serine-Threonine Protein Phosphatase

Research Project

Project/Area Number	21603015
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Chemical biology
Research Institution	Osaka Ohtani University
Principal Investigator	MIYASHITA Kazuyuki 大阪大谷大学, 薬学部, 教授 (10166168)
Co-Investigator(Kenkyū-buntansha)	IKEJIRI Masahiro 大阪大谷大学, 薬学部, 講師 (00412396)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	プロテインホスファターゼ / 阻害剤 / シグナル伝達 / 酵素
Research Abstract	We were interested in development of specific inhibitors for PP1 and PP2A, which would be expected to contribute to mechanistic elucidation of a cellular signal transduction as a final goal. For the purpose, we tried to search for specific substrates for the enzymes, PP1 and PP2A, as a first step. We expected that the specific substrate could be transformed into a specific inhibitor by a partial structural transformation. As a result, we succeeded to find the specific substrate for PP1.

Report

(4 results)