2011 Fiscal Year Final Research Report
Development of Inhibitors for Serine-Threonine Protein Phosphatase
Project/Area Number |
21603015
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical biology
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Research Institution | Osaka Ohtani University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
IKEJIRI Masahiro 大阪大谷大学, 薬学部, 講師 (00412396)
|
Project Period (FY) |
2009 – 2011
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Keywords | プロテインホスファターゼ / 阻害剤 / シグナル伝達 / 酵素 |
Research Abstract |
We were interested in development of specific inhibitors for PP1 and PP2A, which would be expected to contribute to mechanistic elucidation of a cellular signal transduction as a final goal. For the purpose, we tried to search for specific substrates for the enzymes, PP1 and PP2A, as a first step. We expected that the specific substrate could be transformed into a specific inhibitor by a partial structural transformation. As a result, we succeeded to find the specific substrate for PP1.
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