Development of Inhibitors for Serine-Threonine Protein Phosphatase
Project/Area Number |
21603015
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical biology
|
Research Institution | Osaka Ohtani University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
IKEJIRI Masahiro 大阪大谷大学, 薬学部, 講師 (00412396)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | プロテインホスファターゼ / 阻害剤 / シグナル伝達 / 酵素 |
Research Abstract |
We were interested in development of specific inhibitors for PP1 and PP2A, which would be expected to contribute to mechanistic elucidation of a cellular signal transduction as a final goal. For the purpose, we tried to search for specific substrates for the enzymes, PP1 and PP2A, as a first step. We expected that the specific substrate could be transformed into a specific inhibitor by a partial structural transformation. As a result, we succeeded to find the specific substrate for PP1.
|
Report
(4 results)
Research Products
(1 results)
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[Journal Article]2009
Author(s)
宮下和之, 今西武(分担執筆)
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Journal Title
天然物全合成の最新動向(フォストリエシンおよびロイストロダクシンBの全合成)(シーエムシー出版)
Pages: 68-80
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