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In vivo tissue characterization for normal and disease models using diffusion spectral imaging

Research Project

Project/Area Number 21613010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Non-invasive neuroimaging
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

JEFFREY Kershaw  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 準技術員 (50508801)

Co-Investigator(Renkei-kenkyūsha) AOKI Ichio  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519)
OBATA Takayuki  独立行政法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー (00285107)
Research Collaborator AUTIO Joonas  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 技術員
CHRISTOPH Leuze  MAX Planck Institute for Human Congnitive and Brain Leipzig
SHIBATA Sayaka  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 技術員
ITO Hiroshi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (20360357)
TAKUWA Hiroyuki  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (40508347)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords水分子拡散 / 拡散MRI / 変調傾斜磁場 / 小脳 / 拡散時間 / 高磁場MRI / ラット / oscillating gradient / 拡散スペクトル / MRI / 脳機能画像 / BOLD / 拡散係数 / 短拡散時間
Research Abstract

(1) A protocol to perform Diffusion spectroscopic imaging(DSI) by adding oscillating MPG pulses to a spin-echo sequence has been developed four our high-field preclinical 7T-MRI.(2) A theoretical model for the DSI was investigated using micro-particle samples(in vitro) and cerebellum of the rats(in vivo).(3) DSI has been applied to a glioma model in vivo and the detectability evaluated. The non-invasive DSI method will be useful technique for characterising tissue/cellular microstructure.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (20 results)

  • [Journal Article] Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI(dMEMRI)2011

    • Author(s)
      Leuze C, Kimura Y, Kershaw J, Shibata S, Saga T, Chuang KH, Shimoyama I, Aoki I
    • Journal Title

      NeuroImage

      Volume: 60巻 Issue: 1 Pages: 392-399

    • DOI

      10.1016/j.neuroimage.2011.12.030

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging2011

    • Author(s)
      Odaka K, Minamino T, et al
    • Journal Title

      PLos One

      Volume: 6 Issue: 10 Pages: e25487-e25487

    • DOI

      10.1371/journal.pone.0025487

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High b-value diffusion-weighted fMRI in a rat forepaw electrostimulation model at 7T2011

    • Author(s)
      Autio JAA, Kershaw J, Shibata S, Obata T, Kanno I, Aoki I
    • Journal Title

      NeuroImage

      Volume: 57巻 Issue: 3 Pages: 140-148

    • DOI

      10.1016/j.neuroimage.2011.01.006

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High b-value diffusion-weighted fMRI in a rat forepaw electrostimulation model at 7 T2011

    • Author(s)
      Autio JA, Kershaw J, Shibata S, Obata T, Kanno I, Aoki I
    • Journal Title

      Neuroimage

      Volume: 57 Issue: 1 Pages: 140-8

    • DOI

      10.1016/j.neuroimage.2011.04.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative and Noninvasive Assessment of Prenatal X-Ray-Induced CNS Abnormalities Using Magnetic Resonance Imaging2011

    • Author(s)
      Saito S, Aoki I, Kershaw J, et al
    • Journal Title

      Radiat Res

      Volume: 175 Pages: 1-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI2009

    • Author(s)
      Jeffrey Kershaw, Moyoko Tomiyasu, Kenichi Kashikura, Yoshiyuki Hirano, Hiroi Nonaka, Hiroo Ikehira, Iwao Kanno, Takayuki Obata, et al
    • Journal Title

      NMR in Biomedicine

      Volume: 22巻 Pages: 770-778

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI2009

    • Author(s)
      Jeffrey Kershaw, Moyoko Tomiyasu, Kenichi Kashikura, Yoshiyuki Hirano, Hiroi Nonaka, Hiroo Ikehira, Iwao Kanno, Takayuki Obata, et.al
    • Journal Title

      NMR in Biomedicine 22

      Pages: 770-778

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Biexponentioal modeling of diffusion-weighted MRI of rat brain before and after global ischaemia2011

    • Author(s)
      Jeffrey Kershaw
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      北九州市:リーガロイヤルホテル小倉
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Biexponential modeling of diffusion-weighted MRI of rat brain before and after global ischaemia2011

    • Author(s)
      Jeffrey Kershaw, et al
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      北九州
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alternative interpretations for high b-value diffusion-weighted fMRI signal changes2011

    • Author(s)
      Jeffrey Kershaw
    • Organizer
      第13回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都市:京都国際会館
    • Year and Date
      2011-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Alternative interpretations for high b-value diffusion-weighted fMRI signal changes2011

    • Author(s)
      Jeffrey Kershaw
    • Organizer
      第13回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Changes to the fractional anisotropy and mean diffusivity of in vivo rat brain measured at short effective diffusion-times2011

    • Author(s)
      Jeff Kershaw, Christoph Leuze, Takayuki Obata, Iwao Kanno, Ichio Aoki
    • Organizer
      19th Annual Meeting & Exhibition
    • Place of Presentation
      カナダ:モントリオール
    • Year and Date
      2011-05-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Changes to the fractional anisotropy and mean diffusivity of in vivo rat brain measured at short effective diffusion-times2011

    • Author(s)
      Jeffrey Kershaw
    • Organizer
      19th Annual Meeting & Exhibition
    • Place of Presentation
      モントリオール
    • Year and Date
      2011-05-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Observation of modified diffusion anisotropy in in vivo rat cerebellum using oscillating-diffusion-tensor MRI2010

    • Author(s)
      Jeffrey Kershaw, Christoph Leuze, Joonas Autio, Sayaka Shibata, Takayuki Obata, Iwao Kanno, Ichio Aoki
    • Organizer
      日本分子イメージング学会第5回総会
    • Place of Presentation
      大津市:ピアザ淡海
    • Year and Date
      2010-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Observation of modified diffusion anisotropy in in vivo rat cerebellumusing oscillating-gradient diffusion-tensor MRI2010

    • Author(s)
      Jeffrey Kershaw, Christoph Leuze, Joonas Autio, Sayaka Shibata, Takayuki Obata, Iwao Kanno, Ichio Aoki.
    • Organizer
      日本分子イメージング学会第5回総会
    • Place of Presentation
      大津市:ピアザ淡海
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Investigating ADC at short effective diffusion-times using oscillating-gradient diffusion MRI2010

    • Author(s)
      Jeffrey Kershaw, Takayuki Obata, Chistoph Leuze, Autio Joonas, Ichio Aoki
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市:エポカルつくば
    • Related Report
      2011 Final Research Report
  • [Presentation] Investigating ADC at short effective diffusion-times using oscillating-gradient diffusion MRI2010

    • Author(s)
      Jeffrey Kershaw, Takayuki Obata, Chistoph Leuze, Autio Joonas, Ichio Aoki
    • Organizer
      World Molecurar Imaging Congress 2010
    • Place of Presentation
      京都市:国立京都国際会館
    • Related Report
      2011 Final Research Report
  • [Presentation] Observation of modified diffusion anisotropy in in vivo rat cerebellum using oscillating-diffusion-tensor MRI2010

    • Author(s)
      Jeffrey Kershaw, Christoph Leuze, Joonas Autio, Sayaka Shibata, Takayuki Obata, Iwao Kanno, Ichio Aoki
    • Organizer
      World Magnetic Resonance Conference
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Observation of modified diffusion anisotropy in in vivo rat cerebellumusing oscillating-gradient diffusion-tensor MRI2010

    • Author(s)
      Jeffrey Kershaw, Christoph Leuze, Joonas Autio, Sayaka Shibata, Takayuki Obata, Iwao Kanno, Ichio Aoki.
    • Organizer
      Worldwide Magnetic Resonance Conference
    • Place of Presentation
      Florence, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] Apparent diffusion anisotropy in rat cerebellum is altered at short effective diffusion-times using oscillating-gradient diffusion-tensor MRI2010

    • Author(s)
      Jeffrey Kershaw, Christoph Leuze, Autio Joonas, Sayaka Shibata, Takayuki Obata, Iwao Kanno, Ichio Aoki
    • Organizer
      World Molecular Imaging Congress 2010
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Investigating ADC at short effective diffusion-times usingoscillating-gradient diffusion-tensor MRI2010

    • Author(s)
      Jeffrey Kershaw, Takayuki Obata, Christoph Leuze, Autio Joonas, Ichio Aoki
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市:エポカルつくば
    • Related Report
      2010 Annual Research Report
  • [Presentation] 移植細胞の動態評価法の開発:急性心筋梗塞ラットにおけるマンガン標識とインジウム111標識の比較2009

    • Author(s)
      小高謙一、青木伊知男、Kershaw Jeffrey、菊池達矢、福村利光、菅野巌、田所裕之、森谷純治、舘野馨、南野徹、小室一成
    • Organizer
      第32回千葉大学循環病態医科学・循環器内科懇話会
    • Place of Presentation
      千葉市:京成ミラマーレ
    • Year and Date
      2009-12-13
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Diffusion-Weighted fMRIにおける視覚刺激時のR2の変化2009

    • Author(s)
      黒岩大悟、川口拓之、Kershaw Jeffrey、橘篤導、青木伊知男、菅野巌、小畠隆行
    • Organizer
      日本磁気共鳴医学会
    • Place of Presentation
      横浜市:パシフィック横浜ベイホテル東急
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 低拡散水が包含する情報細胞の選択的画像化-低拡散信号によるファンクショナルMRI-2009

    • Author(s)
      黒岩大悟、Kershaw Jeffrey、川口拓之、ヨーナスオーティオ、平野勝也、青木伊知男、菅野巌、小畠隆行
    • Organizer
      日本分子イメージング学会
    • Place of Presentation
      東京:学術総合センター
    • Related Report
      2011 Final Research Report
  • [Presentation] Diffusion-Weighted TE-dependent fMRI Signal in Rat Somatosensory Cortex at 7T2009

    • Author(s)
      Autio Joonas, Jeffrey Kershaw, Takayuki Obata, Daigo Kuroiwa, Iwao Kanno, Ichio Aoki
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      ホノルル: Hawai' I Convention Center
    • Related Report
      2011 Final Research Report
  • [Presentation] Diffusion-Weighted TE-dependent fMRI Signal in Rat Somatosensory Cortex at 7 T2009

    • Author(s)
      Autio Joonas, Jeffrey Kershaw, Takayuki Obata, Daigo Kuroiwa, Iwao Kanno, Ichio Aoki
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      ホノルル:Hawai'i Convention Center
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低拡散水が包含する細胞情報の選択的画像化-低拡散水信号によるファンクショナルMRI-2009

    • Author(s)
      黒岩大悟、Kershaw Jeffrey、川口拓之、ヨーナスオーティオ、平野勝也、青木伊知男、菅野巖、小畠隆行
    • Organizer
      日本分子イメージング学会
    • Place of Presentation
      東京:学術総合センター
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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