Development of a real time diagnosis of lymph node metastasis by ultrasound and nanobubbles
| Project/Area Number |
21650124
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Tohoku University |
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Principal Investigator |
KODAMA Tetsuya 東北大学, 大学院・医工学研究科, 教授 (40271986)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASE Toshiyuki 東北大学, 流体科学研究所, 教授 (30135313)
小野 栄夫 東北大学, 大学院・医学系研究科, 教授 (20302218)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | がん / ナノバブル / 超音波 / 転移 / リンパ節 |
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| Research Abstract |
The aim of the present study is to develop a real time diagnostic method of lymphatic metastasis less than 1cm in diameter. First we developed the color difference based on standard deviation (CDSD)method. Next we succeeded in extracting vascular structures in the tumors of less than 1 cm in diameter by high-frequency ultrasound (HF-US)system, nanobubbles (NBs), and the CDSD method. We applied the methodology to the lymphatic metastasis model, and found that it was applicable to early diagnostic and treatment evaluation of lymphatic metastasis.
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Report
(4 results)
Research Products
(53 results)
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[Presentation] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin2010
Author(s)
Yagishita Y, Takata Y, Ohki K, Miyashita H, Morikawa H, Sakamoto M, Mori S, Kawamura H, Kodama T
Organizer
The 5th International Symposium on Medical, Bio-and Nano-Electronics
Place of Presentation
Sendai, Japan(Book of Abstract)
Related Report
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[Presentation] Four-dimensional high-frequency ultrasound imaging system for early detection of lymph node micro-metastasis2010
Author(s)
Li L, Horie S, Rui CHEN, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T
Organizer
The 5th International Symposium on Medical, Bio-and Nano-Electronics
Place of Presentation
Sendai, Japan(Book of Abstract)
Related Report
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[Presentation] Ultrasound molecular imaging of lymph node metastasis with nano/microbubbles. International Symposium of AIDS and Tuberculosis (ISAT2010)2010
Author(s)
Li L, Chen R, Horie S, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T
Organizer
International Symposium of AIDS and Tuberculosis (ISAT2010)
Place of Presentation
Sendai, Japan
Related Report
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