| Project/Area Number |
21651091
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KITA Masaki 筑波大学, 数理物質系, 准教授 (30335012)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 共生現象 / 天然物化学 / 単離と構造 / 生物活性 |
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| Research Abstract |
We investigated the bioactive key natural products that serve the symbiotic relationship between host animals and symbionts or act as defense substances from predators in marine ecosystem. We determined the planar and partial relative structures of symbiodinolide, metabolite from a symbiotic dinoflagellate, by using unique degradation reactions.Wealso(a) established that this compound was a potent N-type Ca channel agonist. We discovered that the extract of an Alcyonarian coral shows potent inflammatory activity, and successfully isolated tryptamine and a water-soluble small molecule as active substances.
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