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Selective labeling, imaging, and functional control of living cells

Research Project

Project/Area Number 21651096
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionOsaka University

Principal Investigator

FUKASE Koichiz  大阪大学, 大学院・理学研究科, 教授 (80192722)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords蛍光標識 / 蛍光イメージング / PETイメージング / 複合体糖鎖 / 癌細胞 / 転移 / 複合体 / 糖鎖 / 糖鎖クラスター / デンドリマー / 分子認識 / イメージング / 陽電子断層撮影
Research Abstract

New less-invasive labeling of living cells was established and applied to imaging studies based on 6π-azalectrocyclization reaction. The efficient method for the conjugation of bio-molecules was also developed using 6π-azalectrocyclization. A new antitumor molecule was developed by using template-assisted conjugation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (154 results)

All 2012 2011 2010 2009 Other

All Journal Article (24 results) (of which Peer Reviewed: 22 results) Presentation (112 results) Book (16 results) Remarks (2 results)

  • [Journal Article] Cell surface biotinylation by azaelectrocyclization and versatile approach for living cell labeling, Bioorg2012

    • Author(s)
      Tanaka, K., Yokoi, S., Morimoto, K., Iwata, T., Nakamoto, Y., Nakayama, K., Koyama, K., Fujiwara, T., Fukase, K
    • Journal Title

      Med. Chem

      Volume: 0 Pages: 1865-1868

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auxiliary-directed oxidation of ursolic acid by' Ru'-porphyrins : chemical modulation of cytotoxicity against tumor cell lines2012

    • Author(s)
      Tanaka, K., Mazumder, K., Siwu, E. R. O., Nozaki, Satoshi, Watanabe, Y., Fukase, K
    • Journal Title

      Tetrahedron Lett

      Volume: 53 Pages: 1756-1759

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auxiliary-directed oxidation of ursolic acid by 'Ru'-porphyrins : chemical modulation of cytotoxicity against tumor cell lines2012

    • Author(s)
      Tanaka, K., Mazumder, K., Siwu, E.R.O., Nozaki, Satoshi, Watanabe, Y., Fukase, K.
    • Journal Title

      Tetrahedron Lett.

      Volume: 53 Issue: 14 Pages: 1756-1759

    • DOI

      10.1016/j.tetlet.2012.01.107

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain2011

    • Author(s)
      Tanaka, K., Shirotsuki, S., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E. R. O., Iwata, T., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y., Fukase, K
    • Journal Title

      ACS Chem. Biol

      Volume: 7 Pages: 637-644

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Target-selective and fluorescence" switch-on" protein labeling by 6π-azaelectrocyclization2011

    • Author(s)
      Tanaka, K., Kitadani, M., Fukase, K
    • Journal Title

      Org. Biomol. Chem

      Volume: 9 Pages: 5346-5349

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exploring a unique reactivity of 6π-azaelectrocyclization to enzyme inhib ition, natural products synthesis, and molecular imaging : an approach to chemical biology by synthetic chemis ts2011

    • Author(s)
      Tanaka, K., Fukase, K., Katsumura, S
    • Journal Title

      Synlett

      Volume: 15 Pages: 2115-2139

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity Effects of Glycan Clusters on Microarrays and Dendrimers2011

    • Author(s)
      K.Tanaka
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 23 Issue: 131 Pages: 155-157

    • DOI

      10.4052/tigg.23.155

    • NAID

      10029583041

    • ISSN
      0915-7352, 1883-2113
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Template-assisted and self-activating clicked peptide as a synthetic mimic of SH2 domain2011

    • Author(s)
      Tanaka, K., Shirotsuki, S., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E.R.O., Iwata, T., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y., Fukase, K
    • Journal Title

      ACS Chem.Biol.

      Volume: (未定)(in press) Issue: 4 Pages: 637-645

    • DOI

      10.1021/cb2003175

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Target-selective and fluorescence "switch-on" protein labeling by 6Π-azae lectrocyclization2011

    • Author(s)
      Tanaka, K., Kitadani, M., Fukase, K.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Issue: 15 Pages: 5346-5349

    • DOI

      10.1039/c1ob05320e

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploring a unique reactivity of 6II-azaelectrocyclization to enzyme inhibition, natural products synthesis, and molecular imaging : an approach to chemical biology by synthetic chemists2011

    • Author(s)
      Tanaka, K., Fukase, K., Katsumura, S.
    • Journal Title

      Synlett

      Volume: 15 Issue: 15 Pages: 2115-2139

    • DOI

      10.1055/s-0030-1261192

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric synthesis of^<14> C-labeled L-Proparagylglycine2010

    • Author(s)
      Kurosawa, M., Tanaka, K., and Fukase, K
    • Journal Title

      Radioisotopes

      Volume: 59(12) Pages: 721-726

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive imaging of dendrimer-type N-glycan clusters : in vivo dynamics dependence on oligosaccharide structure, Chen, C. W., Paulson, C. J., Watanabe, Y., Fukase, K2010

    • Author(s)
      Tanaka, K., Siwu, R. O. E., Minami, K., Hasegawa, K., Nozaki, S., Kanayama, Y., Koyama, K
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 49 Pages: 8195-8200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] New strategy in synthetic biology : from enzyme inhibition and natural products synthesis to PET imaging by 6π-azaelectrocyclization2010

    • Author(s)
      Tanaka, K., Fukase, K., Katsumura, S.
    • Journal Title

      The Chemical Record

      Volume: 10 Pages: 119-139

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A combined 6π-azaelectrocyclization/ staudinger approach to protein & cell engineering : non-invasive tumor targeting by N-Glycan-engineered lymphocytes2010

    • Author(s)
      Tanaka, K., Minami, K., Tahara, T., Siwu, E. R. O., Koyama, K., Nozaki, S., Onoe, H., Watanabe, Y., Fukase, K.
    • Journal Title

      J. Carbohydr. Chem.

      Volume: 29 Pages: 118-132

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrocyclization-based labeling allows efficient in Vivo imaging of cellular trafficking2010

    • Author(s)
      Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E. R. O., Nozaki, S.; Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., Fukase, K.
    • Journal Title

      ChemMedChem

      Pages: 841-845

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric synthesis of ^<14>C-labeled L-Proparagylglycine2010

    • Author(s)
      Kurosawa, M., Fukase, K., et al.
    • Journal Title

      Radioisotopes

      Volume: 59(12) Pages: 17-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive imaging of dendrimer-type N-glycan clusters : in vivo dynamics dependence on oligosaccharide structure.2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      Angew.Chem.Int.Ed.

      Volume: 49 Pages: 8195-8200

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New strategy in synthetic biology : from enzyme inhibition and natural products synthesis to PET imaging by 6II-azaelectrocyclization2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      The Chemical Record

      Volume: 10 Pages: 119-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A combined 6p-azaelectrocyclization/staudinger approach to protein & cell engineering : non-invasive tumor targeting by N-Glycan-engineered lymphocytes2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      J.Carbohydr.Chem.

      Volume: 29 Pages: 118-132

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrocyclization-based labeling allows efficient in Vivo imaging of cellular trafficking2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      ChemMedChem

      Volume: 5 Pages: 841-845

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Library-directed Solution-and Solid-phase Synthesis of 2, 4-Disubstituted Pyridines : One-pot Approach through 6. pi.-Azaelectrocyclization2009

    • Author(s)
      Sakaguchi, T., Kobayashi, T., Hatano, S., Tsuchikawa, H., Fukase, K., Tanaka, K., and Katsumura, S.
    • Journal Title

      Chemistry-An Asian Journal

      Volume: 4(10) Pages: 1573-1577

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Library-directed Solution- and Solid-phase Synthesis of 2, 4-Disubstituted Pyridines : One-pot Approach through 6.pi.-Azaelectrocyclization2009

    • Author(s)
      Sakaguchi, T.
    • Journal Title

      Chemistry-An Asian Journal 4(10)

      Pages: 1573-1577

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      田中克典, 深瀬浩一
    • Journal Title

      複合糖質の化学と最新応用技術(鎖のインビボバイオイメージング)

      Pages: 235-244

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      田中克典, 深瀬浩一
    • Journal Title

      第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー,月刊BIO INDUSTRY(シーエムシー出版.)

      Pages: 29-36

    • Related Report
      2009 Annual Research Report
  • [Presentation] 固相上での閉環メタセシス/鋳型誘起反応を駆使した癌ターゲティングペプチドの創成2012

    • Author(s)
      岩田隆幸、田原強、野崎聡、渡辺恭良、田中克典、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Related Report
      2011 Final Research Report
  • [Presentation] 固相上での閉環メタセシス/鋳型誘起反応を駆使した癌ターゲティングペプチドの創成2012

    • Author(s)
      岩田隆幸、田原強、野崎聡、渡辺恭良、田中克典、深瀬浩一
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン酸化タンパク質認識ペプチドの創製とその抗腫瘍作用2011

    • Author(s)
      深瀬浩一
    • Organizer
      第14回ペプチドフォーラム
    • Place of Presentation
      鹿児島大学理学部
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] リン酸化タンパク質認識ペプチドの創製とその抗腫瘍作用2011

    • Author(s)
      深瀬浩一
    • Organizer
      第14回ペプチドフォーラム
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 固相上での閉環メタセシスとHuisgen環化反応を経た人工抗癌ペプチドの効率合成と評価2011

    • Author(s)
      岩田隆幸、田原強、野崎聡、渡辺恭良、田中克典、深瀬浩一
    • Organizer
      第31回有機合成若手セミナー「明日の有機合成を担う人のために」
    • Place of Presentation
      京都大学吉田キャンパス
    • Year and Date
      2011-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 固相上での閉環メタセシスとHuisgen環化反応を経た人工抗癌ペプチドの効率合成と評価2011

    • Author(s)
      岩田隆幸、田原強、野崎聡、渡辺恭良、田中克典、深瀬浩一
    • Organizer
      回有機合成若手セミナー「明日の有機合成を担う人のために」
    • Place of Presentation
      京都大学
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 有機合成と生体イメージングを用いて糖鎖の生物機能を解明する2011

    • Author(s)
      深瀬浩一
    • Organizer
      第4回生体分子科学シンポジウム(第2回ケミカルバイオロジー研究所シンポジウム)
    • Place of Presentation
      大阪府立大学理学系研究科
    • Year and Date
      2011-03-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 有機合成と生体イメージングを用いて糖鎖の生物機能を解明する2011

    • Author(s)
      深瀬浩一
    • Organizer
      第4回生体分子科学シンポジウム
    • Place of Presentation
      大阪府立大学理学系研究科(招待講演)
    • Year and Date
      2011-03-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glyco-imag ing for glycan dynamics study2011

    • Author(s)
      K. Fukase
    • Organizer
      The 71st Okazaki Conference" New perspectives o n molecular science of glycoconjugates"
    • Place of Presentation
      Osakazaki Conference Center, NINS, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 標的リジンとの電子環状反応に起因するドミノ反応型蛍光回復標識法2011

    • Author(s)
      北谷方嵩、田中克典、深瀬浩一
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」
    • Related Report
      2011 Final Research Report
  • [Presentation] 鋳型誘起合成によるGrb2-SH2ドメインイディオタイプの創製と生体内シグナルの制御2011

    • Author(s)
      岩田隆幸, 白坏早苗, 景山知佳, 田原強, 野崎聡, 渡辺恭良, 田中克典, 深瀬浩一
    • Organizer
      天然物化学談話会
    • Place of Presentation
      熱川ハイツ(静岡県)
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞のグライコイメージング2011

    • Author(s)
      深瀬浩一
    • Organizer
      第6回日本分子イメージング学会
    • Place of Presentation
      神戸国際会議場、糖タンパク質、糖鎖クラスター
    • Related Report
      2011 Final Research Report
  • [Presentation] New functional analysis of glycans based on chemical synthesis and bio-imaging2011

    • Author(s)
      Koichi Fukase
    • Organizer
      Frontiers of Chemical Biology at Peking University Shenzhen Graduate School, the School of Chemical B iology and Biotechnology
    • Place of Presentation
      China
    • Related Report
      2011 Final Research Report
  • [Presentation] 標的指向型ライブラリー構築と生命科学への貢献2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 精密有機合成と生体イメージングを基盤とする生物活性複合糖質の機能解明2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 免疫制御を指向したケミカルグリコバイオロジー2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Glyco-imaging for glycan dynamics study2011

    • Author(s)
      K.Fukase
    • Organizer
      The 71st Okazaki Conference "New perspectives on molecular science of glycoconjugates"
    • Place of Presentation
      愛知県、Osakazaki Conference Center(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 標的リジンとの電子環状反応に起因するドミノ反応型蛍光回復標識法2011

    • Author(s)
      北谷方嵩、田中克典、深瀬浩一
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      茨城県、つくば国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] 鋳型誘起合成によるGrb2-SH2ドメインイディオタイプの創製と生体内シグナルの制御2011

    • Author(s)
      岩田隆幸, 白坏早苗, 景山知佳, 田原強, 野崎聡, 渡辺恭良, 田中克典, 深瀬浩一
    • Organizer
      第46回天然物化学談話会
    • Place of Presentation
      静岡県、熱川ハイツ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖タンパク質、糖鎖クラスター、細胞のグライコイメージング2011

    • Author(s)
      深瀬浩一
    • Organizer
      第6回日本分子イメージング学会
    • Place of Presentation
      神戸国際会議場(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] New functional analysis of glycans based on chemical synthesis and bio-imaging2011

    • Author(s)
      Koichi Fukase
    • Organizer
      Frontiers of Chemical Biology
    • Place of Presentation
      Peking University, China
    • Related Report
      2011 Annual Research Report
  • [Presentation] 標的指向型ライブラリー構築と生命科学への貢献2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精密有機合成と生体イメージングを基盤とする生物活性複合糖質の機能解明2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫制御を指向したケミカルグリコバイオロジー2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Isolation and Cytotoxicity of Ursolic Acid Derivatives from Bangladeshi Medicinal Plants, Saurauja roxburghii2011

    • Author(s)
      M.Kishor, K.Fukase
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of Polylysine-Based N-Glycans Dendrimers as Noninvasive Imaging Tracers2010

    • Author(s)
      Katsunori Tanaka, Eric R. O. Siwu, Tohru Watanabe, and Koichi Fukase
    • Organizer
      5^<th> International Peptide Symposium
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2010-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Self-Activating" & Induced-Fit" Approach to Peptidyl Mimic of Grb2-SH2 Domain2010

    • Author(s)
      K. Tanaka, T. Iwata, S. Shirotsuki, C. Kageyama, T. Tahara, S Nozaki, E. R. O. Siwu, S. Tamura, S. Douke, N. Murakami, H. Onoe, Y. Watanabe, K. Fukase
    • Organizer
      5^<th> International Peptide Symposium
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2010-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthesis of Polylysine-Based N-Glycan Dendrimers as Noninvasive Imaging Tracers2010

    • Author(s)
      K., Tanaka, K.Fukase
    • Organizer
      5^<th> International Peptide Symposium
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Self-Activating & Induced-Fit" Approach to Peptidyl Mimic of Grb2-SH2 Domain2010

    • Author(s)
      K., Tanaka, K.Fukase
    • Organizer
      5^<th> International Peptide Symposium
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非侵襲的イメージングを用いたタンパク質、細胞、およびデンドリマー上のN-結合型糖鎖の機能解析-N-結合型糖鎖による非侵襲的イメージングとターゲティング2010

    • Author(s)
      田中克典・深瀬浩一
    • Organizer
      第59回高分子学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 非侵襲的イメージングを用いたタンパク質、細胞、およびデンドリマー上のN-結合型糖鎖の機能解析-N-結合型糖鎖による非侵襲的イメージングとターゲティング-2010

    • Author(s)
      田中克典、深瀬浩一
    • Organizer
      第59回高分子学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Azaelectrocyclization-Based Labeling & Engineering Allow Non-Invasive Imaging of Cellular Trafficking and Tumor Targeting by Lymphocytes2010

    • Author(s)
      Katsunori Tanaka, Kaori Minami, Tsuyoshi Tahara, Yohei Fujii, Eric, R. O. Siwu, Satoshi Nozaki, Hirotaka Onoe, Satomi Yokoi, Koichi Koyama, Yasuyoshi Watanabe, and Koichi Fukase
    • Organizer
      World Molecular Imaging Congress(WMIC)
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2010-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Azaelectrocyclization-Based Labeling & Engineering Allow Non-Invasive Imaging of Cellular Trafficking and Tumor Targeting by Lymphocytes2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      World Molecular Imaging Congress (WMIC)
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 基質隣接効果による初めての"head-to-head"イミン二量化反応:縮環1,2-ジアゼチジンの直接的[2+2]合成2010

    • Author(s)
      広崎真司、深瀬浩一
    • Organizer
      第37回有機反応懇談会
    • Place of Presentation
      京都大学宇治キャンパス
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] リン酸化タンパク質を鋳型とした選択的ペプチド連結反応の開発と細胞内シグナル伝達を制御する機能性分子創成への応用2010

    • Author(s)
      岩田隆幸、白坏早苗、景山知佳、田原強、野崎聡、渡辺恭良、田中克典、深瀬浩一
    • Organizer
      第37回有機反応懇談会
    • Place of Presentation
      京都大学宇治キャンパスおうばくプラザきはだホール
    • Year and Date
      2010-08-02
    • Related Report
      2011 Final Research Report
  • [Presentation] リン酸化タンパク質を鋳型とした選択的ペプチド連結反応の開発と細胞内シグナル伝達を制御する機能性分子創成への応用2010

    • Author(s)
      岩田隆幸、深瀬浩一
    • Organizer
      第37回有機反応懇談会
    • Place of Presentation
      京都大学宇治キャンパス
    • Year and Date
      2010-08-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Azaelectrocyclization-Based Labelling and Bioconjugation of Proteins and Living Cells : Application to Imaging of N-Glycans and Lymphocyte2010

    • Author(s)
      Koichi Fukase
    • Organizer
      The 4th HiPep-Okinawa International Workshp
    • Place of Presentation
      Okinawa Industry Support Center
    • Year and Date
      2010-07-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Azaelectrocyclization-Based Labelling and Bioconjugation of Proteins and Living Cells : Application to Imaging of N-Glycans and Lymphocytes2010

    • Author(s)
      K.Fukase
    • Organizer
      The 4th HiPep-Okinawa International Workshop
    • Place of Presentation
      Okinawa Industry Support Center(招待講演)
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] in vivo生体分子科学を目指した生物活性プローブの創成:糖鎖のPETイメージングプローブとSH2ドメインミミック2010

    • Author(s)
      深瀬浩一
    • Organizer
      第16回数理医学研究会
    • Place of Presentation
      大阪大学基礎工学研究科
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] in vivo生体分子科学を目指した生物活性プローブの創成:糖鎖のPETイメー ジングプローブとSH2ドメインミミック2010

    • Author(s)
      深瀬浩一
    • Organizer
      第16回数理医学研究会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] タンパク質、糖鎖の迅速標識法とPETへの応用2010

    • Author(s)
      深瀬浩一
    • Organizer
      保健医療分野における基礎研究推進事業「TGF-β活性化反応を標的とした肝疾患の新規診断法、治療・予防法の開発」研究班シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2010-02-20
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質、糖鎖の迅速標識法とPETへの応用2010

    • Author(s)
      深瀬浩一
    • Organizer
      保健医療分野における基礎研究推進事業「TGFβ活性化反応を標的とした肝疾患の新規診断法、治療・予防法の開発」研究班シンポジウム
    • Place of Presentation
      千里ライフサイェンスセンター(大阪)
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthetic approach for in vivo functional studies of glycans : Applica tion of PET imaging2010

    • Author(s)
      Koichi Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies(Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Azaelectrocyclization-Based Labeling and Engineering of Proteins & Living Cells : Application to Non-invasive Imaging of N-Glycans2010

    • Author(s)
      K. Tanaka and K. Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies(Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthetic Approach for Elucidating Glycan Codes2010

    • Author(s)
      Koichi Fukase, Yukari Fujimoto, Katsunori Tanaka
    • Organizer
      The 5th International Conference on Cutting-Edge Organic Chemistry in Asia(ICCEOCA-5)/ The 1st New phase International Conference on Cutting-Edge Organic Chemistry in Asia(NICCEOCA-1)
    • Place of Presentation
      Ambassador Hotel at Hsinchu, Taiwan
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthetic Approach for Elucidation of Biological Relevance of Glycans2010

    • Author(s)
      Koichi Fukase
    • Organizer
      The Sixth International Symposium on Integrated Synthesis(ISIS-6)
    • Place of Presentation
      Seaside Hotel Maiko Villa Kobe
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthesis of Polylysine-Based Glycodendrimer Through Self-Activating Click Reaction、Tohru Watanabe, Eric Richard Okitavianus2010

    • Author(s)
      Yuka Nakamoto, Katsunori Tanaka, Koichi Fukase
    • Organizer
      The Sixth International Symposiu m on Integrated Synthesis(ISIS-6)
    • Place of Presentation
      Seaside Hotel Maiko Villa Kobe
    • Related Report
      2011 Final Research Report
  • [Presentation] アザ電子環状反応を基盤とするタンパク質および細胞表層の高速標識化とN-結合型糖鎖の"生きている動物内"でのイメージング2010

    • Author(s)
      田中克典、南香莉、Eric R. O. Siwu、増山達郎、小山幸一、横井里美、長谷川功紀、田原強、水間広、野崎聡、金山洋介、和田康弘、尾上浩隆、渡辺恭良、深瀬浩一
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      グランシップ(静岡)
    • Related Report
      2011 Final Research Report
  • [Presentation] 高速6π-アザ電子環状反応による高速アミノ基標識キット、STELLA+の開発2010

    • Author(s)
      田中克典、横井里美、中山郁理、小山幸一、長谷川功紀、田原強、渡辺恭良、深瀬浩一
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪大学
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ポリリジンデンドリマー型糖鎖クラスターの効率的合成を基盤としたN-結合型糖鎖の非侵襲的イメージング2010

    • Author(s)
      南香莉、長谷川功紀、野崎聡、金山洋介、小山幸一、渡辺恭良、深瀬浩一
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪大学
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Noninvasive PET & Fluorescence Imaging of N-Glycans : Sialic Acid-Dependent In Vivo Dynamics of Proteins, Glycoclusters and Living Cell s2010

    • Author(s)
      Katsunori Tanaka and Koichi Fukase
    • Organizer
      Sialoglyco 2010
    • Place of Presentation
      Potsdam, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthetic Approach toward Understanding In Vivo Functions of Glycans2010

    • Author(s)
      Koichi Fukase
    • Organizer
      The 25th International Carbohydrate Symposium(ICS2010)
    • Place of Presentation
      Makuhari Messe(Chiba)
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthetic Study and Biological Investigation of New N-Glycan in、Mouse Brain2010

    • Author(s)
      G. M. Bao, K. Tanaka, K. Ikenaka, K. Fukas e
    • Organizer
      The 25th International Carbohydrate Symposium(ICS2010)
    • Place of Presentation
      Makuhari Messe(Chiba)
    • Related Report
      2011 Final Research Report
  • [Presentation] Chemistry-based Protein & Cell-Surface Engineering by N-Glycans2010

    • Author(s)
      K. Tanaka, K. Minami, E. R. Siwu, K. Fukase
    • Organizer
      The 25th International Carbohydrate Symposium(ICS2010)
    • Place of Presentation
      Makuhari Messe(Chiba)
    • Related Report
      2011 Final Research Report
  • [Presentation] Remarkable Structural Dependency of N-Glycan Clusters on In、Vivo Dynamics2010

    • Author(s)
      E. R. Siwu, K. Tanaka, K. Minami, K. Hasegaw a, S. Nozaki, Y. Kanayama, K. Koyama, W. C. Chen, J. Paulson, Y. Watanabe, K. Fukase
    • Organizer
      The 25th International Carbohydrate Symposium(ICS2010)
    • Place of Presentation
      Makuhari Messe(Chiba)
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖鎖機能研究会・・・分子レベルでの解明を目指して、イメージングを利用した糖鎖の新しい機能探索2010

    • Author(s)
      深瀬浩一、田中克典、Eric Siwu、南香莉、渡辺恭良、長谷川功紀、野崎聡、金山洋介、小山幸一、三善英知、中川勉、里村慎二
    • Organizer
      平成22年度生理学研究所研究会
    • Place of Presentation
      生理学研究所(愛知県)
    • Related Report
      2011 Final Research Report
  • [Presentation] New Synthetic Approach for Phosphopeptide Recognition Module That Shows Antitumor Action to Specific Cancer2010

    • Author(s)
      Koichi Fukase, Katsunori Tanaka, Sanae Shir otsuki, Chika Kageyama, Takayuki Iwata, Tsuyoshi Tahara, Satoshi Nozaki, Akiyoshi Watanabe
    • Organizer
      1st Asian Chemical Biology Conference
    • Place of Presentation
      Seoul National University, Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Induced-fit型クリックペプチドを用いたSH2ドメインイディオタイプ創製への新規合成化学的アプローチ2010

    • Author(s)
      田中克典, 白坏早苗, 景山知佳, 田原強, 野崎聡, 渡辺恭良, 深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      慶応大学〔神奈川県)
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthetic Approach for In Vivo Functional Studies of Glycans2010

    • Author(s)
      Koichi Fukase
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry(FJS2010)
    • Place of Presentation
      Kyoto Garden Palace
    • Related Report
      2011 Final Research Report
  • [Presentation] Unprecedented[ 2+ 2]-Condensation of Imines : Simulataneous C-C & N-N Bond Formations to 1, 2-Diazetidenes2010

    • Author(s)
      Katsunori Tanaka, Shinji Hirosaki, Takayuki Iwata, Eric, R. O. Siwu, Koichi Fukase
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry(FJS2010)
    • Place of Presentation
      Kyoto Garden Palace
    • Related Report
      2011 Final Research Report
  • [Presentation] Non-Invasive In Vivo Imaging of N-Glycans2010

    • Author(s)
      Katsunori Tanaka and Koic hi Fukase
    • Organizer
      International Symposium on Organelle Networks : Interface among Infection-Immunity
    • Place of Presentation
      Cell Biology and Glycobio logy, Senri Life Science Center(Osaka)
    • Related Report
      2011 Final Research Report
  • [Presentation] 6π-電子環状反応を用いたタンパク質への糖鎖エンジニアリング、南香莉、SIWU, Eric R. O.2010

    • Author(s)
      田中克典、深瀬浩一
    • Organizer
      日本化学会第90回春季年会
    • Place of Presentation
      近畿大学(大阪)
    • Related Report
      2011 Final Research Report
  • [Presentation] イメージングを活用した糖鎖のin vivo生体分子科学2010

    • Author(s)
      深瀬浩一
    • Organizer
      第12回生命化学研究会
    • Place of Presentation
      芦原温泉清風荘(福井)
    • Related Report
      2011 Final Research Report
  • [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography(PET)2010

    • Author(s)
      Katsunori Tanaka, Eric R. O. Siwu, Kaori Minami, Koki Hasegawa, Satoshi Nozaki, Yousuke Kanayama, Yasuyoshi Watanabe, Koichi Koyama, Koichi Fukase
    • Organizer
      Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery(CCCB)
    • Place of Presentation
      Senri Life Sc ience Center(Osaka)
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthetic approach for in vivo functional studies of glycans : Application of PET imaging2010

    • Author(s)
      K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unprecedented [2+2]-Condensation of Imines : Remarkable Substituent Effects and Synthetic Applications2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Azaelectrocyclization-Based Labeling and Engineering of Proteins & Living Cells : Application to Non-invasive Imaging of N-Glycans2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Approach for Elucidating Glycan Codes2010

    • Author(s)
      K.Fukase
    • Organizer
      The 5th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-5)/The 1st New phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-1)
    • Place of Presentation
      Hsinchu, Taiwan(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Approach for Elucidation of Biological Relevance of Glycans2010

    • Author(s)
      K.Fukase
    • Organizer
      The Sixth International Symposium on Integrated Synthesis (ISIS-6)
    • Place of Presentation
      Seaside Hotel Maiko Villa Kobe(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of Polylysine-Based Glycodendrimer Through Self-Activating Click Reaction2010

    • Author(s)
      T.Watanabe, K.Fukase
    • Organizer
      The Sixth International Symposium on Integrated Synthesis (ISIS-6)
    • Place of Presentation
      Seaside Hotel Maiko Villa Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] 共役イミン誘導体の初めての[2+2]反応によるワンポット1,2-ジアゼチジン合成2010

    • Author(s)
      田中克典、深瀬浩一
    • Organizer
      第40回複素環化学討論会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] アザ電子環状反応を基盤とするタンパク質および細胞表層の高速標識化とN-結合型糖鎖の"生きている動物内"でのイメージング2010

    • Author(s)
      田中克典、深瀬浩一
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      グランシップ(静岡県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Noninvasive PET & Fluorescence Imaging of N-Glycans : Sialic Acid-Dependent In Vivo Dynamics of Proteins, Glycoclusters and Living Cells2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      Sialoglyco 2010
    • Place of Presentation
      Potsdam, Germany
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Approach toward Understanding In Vivo Functions of Glycans2010

    • Author(s)
      K.Fukase
    • Organizer
      The 25th International Carbohydrate Symposium (ICS 2010)
    • Place of Presentation
      幕張メッセ(千葉県)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Study and Biological Investigation of New N-Glycan in Mouse Brain2010

    • Author(s)
      G.M.Bao, K.Fukase
    • Organizer
      The 25th International Carbohydrate Symposium (ICS 2010)
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemistry-based Protein & Cell-Surface Engineering by N-Glycans2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      The 25th International Carbohydrate Symposium (ICS 2010)
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Remarkable Structural Dependency of N-Glycan Clusters on In Vivo Dynamics2010

    • Author(s)
      E.R.Siwu, K.Fukase
    • Organizer
      The 25th International Carbohydrate Symposium (ICS 2010)
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] イメージングを利用した糖鎖の新しい機能探索2010

    • Author(s)
      深瀬浩一
    • Organizer
      平成22年度生理学研究所研究会
    • Place of Presentation
      生理学研究所(愛知県)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of new probes for chemical glycobiology : application to PET and fluorescent imaging of glycoproteins, glycoclusters, and living cells2010

    • Author(s)
      K.Fukase
    • Organizer
      1st Asian Chemical Biology Conference
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] New Synthetic Approach for Phosphopeptide Recognition Module That Shows Antitumor Action to Specific Cancer2010

    • Author(s)
      K.Fukase
    • Organizer
      1st Asian Chemical Biology Conference
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Approach for In Vivo Functional Studies of Glycans2010

    • Author(s)
      K.Fukase
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry (FJS2010)
    • Place of Presentation
      Kyoto Garden Palace(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unprecedented [2+2]-Condensation of Imines : Simulataneous C-C & N-N Bond Formations to 1,2-Diazetidenes2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry (FJS2010)
    • Place of Presentation
      Kyoto Garden Palace
    • Related Report
      2010 Annual Research Report
  • [Presentation] Induced-fit型クリックペプチドを用いたSH2ドメインイディオタイプ創製への新規合成化学的アプローチ2010

    • Author(s)
      田中克典、深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会 第5回年会
    • Place of Presentation
      慶応大学 日吉キャンパス(神奈川県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Non-Invasive In Vivo Imaging of N-Glycans2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      International Symposium on Organelle Networks : Interface among Infection-Immunity, Cell Biology and Glycobiology
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 6II-電子環状反応を用いたタンパク質への糖鎖エンジニアリング2010

    • Author(s)
      南香莉
    • Organizer
      日本化学会第90回春季年会
    • Place of Presentation
      近畿大学(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] イミン誘導体の形式的[2+2]反応と合成的展開2010

    • Author(s)
      田中克典
    • Organizer
      日本化学会第90回春季年会
    • Place of Presentation
      近畿大学(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] イメージングを活用した糖鎖のin vivo生体分子科学2010

    • Author(s)
      深瀬浩一
    • Organizer
      第12回生命化学研究会
    • Place of Presentation
      芦原温泉 清風荘(福井)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と糖鎖の新機能解析2009

    • Author(s)
      深瀬浩一
    • Organizer
      第34回有機反応懇談会
    • Place of Presentation
      関西学院大学
    • Year and Date
      2009-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と糖鎖の新機能解析2009

    • Author(s)
      深瀬浩一
    • Organizer
      第34回有機反応懇談会
    • Place of Presentation
      関西学院大学、三田(兵庫)
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] タンパク質、および細胞上での革新的有機合成反応の開発:6p-アザ電子環状反応を用いたシンセティックバイオロジー2009

    • Author(s)
      Eric R.O.Siwu
    • Organizer
      第34回有機反応懇談会
    • Place of Presentation
      関西学院大学、三田(兵庫)
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nanomolar-Scale Lysine Labeling by 6p-Azaelectrocyclization : Biomolecule-and Whole Cell-Based In Vivo Imaging and Tumor Targeting2009

    • Author(s)
      K. Tanaka, K. Minami, E. R. O. Siwu, T. Tahara, S. Nozaki, Y. Watanabe, K. Koyama, S. Yokoi, and K. Fukase
    • Organizer
      Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery(CCCB)
    • Place of Presentation
      Senr i Life Science Center(Osaka)
    • Related Report
      2011 Final Research Report
  • [Presentation] In vivo imaging of glycoproteins and glycoclusters2009

    • Author(s)
      Koichi Fukase, Katsunori Tanaka, Tatsuro Masuyama, Kaori Minami, Eric R. O. Siwu, Koki Hasegawa, Tsuyoshi Tahara, Hiroshi Mizuma, Yasuhiro Wada, Yasuyoshi Watanabe
    • Organizer
      2nd Switzerland. Japan Biomolecular Chemistry Symposium
    • Place of Presentation
      Tokyo Univ.
    • Related Report
      2011 Final Research Report
  • [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と糖鎖の新機能解析2009

    • Author(s)
      深瀬浩一
    • Organizer
      第29回日本糖質学会年会
    • Place of Presentation
      世界生活文化センター(高山)
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular Probe Method for Studying the Biofunctional Role of Glycoconjugates2009

    • Author(s)
      Koichi Fukase
    • Organizer
      The 25th Naito Conference
    • Place of Presentation
      Chemical Biology II-An Emerging Filed Inspir ed by Natural Product Chemistry-, Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography(PET)2009

    • Author(s)
      Eric R. O. Siwu, K. Minami, K. Hasegawa, S. Nozaki, Y. Kanayama, K. Koyama, Y. Watanabe, K. Tanaka, K. Fukase
    • Organizer
      The 25th Naito Conference
    • Place of Presentation
      Chemical Biology II-An Emerging Filed Inspir ed by Natural Product Chemistry-、Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] Fast Labeling of Lysines via 6π-Azaelectrocyclization : Application to Pet Imaging of Glycoproteins and Glycociusters2009

    • Author(s)
      K. Fukase, K. Tanaka, T. Masuyama, K. Minami, E. R. O. Siwu, K. Hasegawa, T. Tahara, H. Mizuma, Y. Wada, Y. Watanabe
    • Organizer
      15th European Carbohydrate Symposium(eurocarb15)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖鎖の合成とin vivo生体分子科学2009

    • Author(s)
      深瀬浩一
    • Organizer
      第44回天然物化学談話会
    • Place of Presentation
      つくばグランドホテル
    • Related Report
      2011 Final Research Report
  • [Presentation] Chemical Glycobiology of Self/ Non-self Recognition2009

    • Author(s)
      K. Fukase
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Carbohydrates, Tilton School, Tilton, NH
    • Related Report
      2011 Final Research Report
  • [Presentation] アスパラギン結合型糖タンパク質糖鎖クラスターの蛍光およびPETイメージング2009

    • Author(s)
      Eric R. O. Siwu1、南香莉、長谷川功紀、野崎聡、金山洋介、渡辺恭良、小山幸一、田中克典、深瀬浩一
    • Organizer
      第4回年会、神戸市産業振興センター
    • Place of Presentation
      日本ケミカルバイオロジー学会
    • Related Report
      2011 Final Research Report
  • [Presentation] ポスタータイトル:高速6π-アザ電子環状反応を用いた細胞表層への化学的標識と糖鎖エンジニアリング:細胞のインビボイメージング2009

    • Author(s)
      南香莉、Eric. R. O. Siwu、田原強、野崎聡、渡辺恭良、小山幸一、田中克典、深瀬浩一
    • Organizer
      第4回年会、神戸市産業振興センター
    • Place of Presentation
      日本ケミカルバイオロジー学会
    • Related Report
      2011 Final Research Report
  • [Presentation] Nanomolar-Scale Lysine Labeling by 6□-Azaelectrocyclization : Biomolecule- and Whole Cell-Based In Vivo Imaging and Tumor Targeting2009

    • Author(s)
      K.Minami
    • Organizer
      Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery(CCCB)
    • Place of Presentation
      Senri Life Science Center(Osaka)
    • Related Report
      2009 Annual Research Report
  • [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography(PET)2009

    • Author(s)
      Eric R.O.Siwu
    • Organizer
      Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery(CCCB)
    • Place of Presentation
      Senri Life Science Center(Osaka)
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo imaging of glycoproteins and glycoclusters2009

    • Author(s)
      Koichi Fukase
    • Organizer
      2nd Switzerland-Japan Biomolecular Chemistry Symposium
    • Place of Presentation
      Tokyo Univ.(Tokyo)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と 糖鎖の新機能解析2009

    • Author(s)
      深瀬浩一
    • Organizer
      第29回日本糖質学会年会
    • Place of Presentation
      世界生活文化センター(高山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography(PET)2009

    • Author(s)
      Eric R.O.Siwu
    • Organizer
      第29回日本糖質学会年会
    • Place of Presentation
      世界生活文化センター(高山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular Probe Method for Studying the Biofunctional Role of Glycoconjugates2009

    • Author(s)
      Koichi Fukase
    • Organizer
      The 25th Naito Conference, Chemical Biology II-An Emerging Filed Inspired by Natural Product Chemistry
    • Place of Presentation
      Chateraise Gateaux Kingdom(Sapporo)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fast Labeling of Lysines Via 6π-Azaelectrocyclization : Application to Pet Imaging of Glycoproteins and Glycociusters2009

    • Author(s)
      Koichi Fukase
    • Organizer
      15th European Carbohydrate Symposium(eurocarb15)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2009 Annual Research Report
  • [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography(PET)2009

    • Author(s)
      Eric R.O.Siwu
    • Organizer
      15th European Carbohydrate Symposium(eurocarb15)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖鎖の合成とin vivo生体分子科学2009

    • Author(s)
      第44回天然物化学談話会
    • Organizer
      第44回天然物化学談話会
    • Place of Presentation
      つくばグランドホテル(つくば)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemical Glycobiology of Self/Non-self Recognition2009

    • Author(s)
      Koichi Fukase
    • Organizer
      Gordon Research Conferences, Carbohydrates
    • Place of Presentation
      Tilton, NH
    • Related Report
      2009 Annual Research Report
  • [Presentation] アスパラギン結合型糖タンパク質糖鎖クラスターの蛍光およびPETイメージング2009

    • Author(s)
      Eric R.O.Siwu1
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸市産業振興センター(神戸)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポスタータイトル:高速6π-アザ電子環状反応を用いた細胞表層への化学的標識と糖鎖エンジニアリング:細胞のインビボイメージング2009

    • Author(s)
      南香莉
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸市産業振興センター(神戸)
    • Related Report
      2009 Annual Research Report
  • [Book] Chemical Approach to A Whole Body Imaging of Sialo-N-linked Glycans, In Topics in Current Chemistry volumes, SialoGlyco Chemistry and Biology2011

    • Author(s)
      K. Tanaka, K. Fukase
    • Publisher
      Springer
    • Related Report
      2011 Final Research Report
  • [Book] 新規標識反応を基盤とする糖鎖プローブの開発とインビボイメージイング,蛍光イメージング/ MRIプローブの開発2011

    • Author(s)
      深瀬浩一, 田中克典
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] ペプチド・タンパク質、細胞の革新的標識法とPETによる動態解析への応用,次世代バイオ医薬品の製剤設計と開発戦略2011

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] Chemical Approach to A Whole Body Imaging of Sialo-N-linked Glycans, In Topics in Current Chemistry volumes in SialoGlyco Chemistry and Biology2011

    • Author(s)
      K.Tanaka, K.Fukase
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] 新規標識反応を基盤とする糖鎖プローブの開発とインビボイメージングin蛍光イメーシング・MRIプローブの開発と最新動向2011

    • Author(s)
      深瀬浩一, 田中克典
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] ペプチド・タンパク質、細胞の革新的標識法とPETによる動態解析への応用in次世代バイオ医薬品の製剤設計と開発戦略2011

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] Self and non-self recognition with bacterial and animal glycans, surveys by synthetic chemistry, Methods in Enzymology2010

    • Author(s)
      Fujimoto, Y., Tanaka, K., Shimoyama, A., Fukase, K.
    • Total Pages
      478
    • Related Report
      2011 Final Research Report
  • [Book] 糖鎖の侵襲的イメージング,「創薬研究への分子イメージング応用」2010

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      メディカルドゥ
    • Related Report
      2011 Final Research Report
  • [Book] 糖鎖関連物質の非侵略的インビボイメージングによる診断法開発への展望,『生体の科学』「糖鎖のかかわる病気」2010

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 糖鎖を用いた生体内イメージングとターゲティング, In Vivo Imaging and Targeting by Oligosaccharides and Related Molecules,第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー、月刊バイオインダストリー2010

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] Methods in Enzymology2010

    • Author(s)
      Fujimoto, Y., Fukase, K.
    • Publisher
      Glycomics
    • Related Report
      2010 Annual Research Report
  • [Book] 創薬研究への分子イメージング応用2010

    • Author(s)
      田中克典、深瀬浩一
    • Publisher
      メディカルドゥ
    • Related Report
      2010 Annual Research Report
  • [Book] 『生体の科学』「糖鎖のかかわる病気」2010

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] 第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー、月刊バイオインダストリー2010

    • Author(s)
      田中克典、深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report
  • [Book] 『生体の科学』「糖鎖のかかわる病気」2010

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] 糖鎖のインビボバイオイメージング,複合糖質の化学と最新応用技術2009

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      株式会社シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/fukase/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/fukase/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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