A novel role of RNA in the function at the replication origins in animal cells
| Project/Area Number |
21657045
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Japan Women's University |
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Principal Investigator |
WAGA Shou 日本女子大学, 理学部, 教授 (60222402)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | DNA複製 / ORC / 非コードRNA / 機能性RNA / 複製開始点 |
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| Research Abstract |
DNA replication is one of the fundamental processes that are required for cell proliferation. We studied the details of activities of ORC, which is one of the proteins that function during the initiation of DNA replication in eukaryotes. We especially focused on the RNA binding activity of human ORC and found that the activity is specific for GU-rich RNA and that at least the ORC1 subunit has the RNA binding activity. Moreover we succeeded in identifying a specific domain for RNA binding activity in the ORC1 protein.
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Report
(4 results)
Research Products
(20 results)
