| Project/Area Number |
21659289
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
SAJI Hideo 京都大学, 大学院・薬学研究科, 教授 (40115853)
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| Co-Investigator(Kenkyū-buntansha) |
TEMMA Takashi 京都大学, 大学院・薬学研究科, 助教 (90378787)
TOYODA Kentaro 京都大学, 大学院・医学研究科, 助教 (00447971)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Hiroyuki 京都大学, 環境安全保健機構・放射性同位元素総合センター, 助教 (50437240)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | 糖尿病 / 早期診断 / 分子イメージング / 画像診断 |
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| Research Abstract |
If a decrease in the amount of pancreatic islets and the amount of pancreatic.-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic.-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic.-cell imaging, has been desired in particular. In designing a molecular probe for imaging of pancreatic.-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the.-cells, are being researched. Among these, GLP-1R and GPR40 are being researched as a target molecule. These data suggest that[111In] K4-Ex4 and[125I] ARKM-405 can be a potential candidate as a SPECT tracer for measuringβ-cell mass in pancreatic islets.
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