Development of artificial antibodies to molecular targets of cancer cells
Project/Area Number |
21659306
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
General surgery
|
Research Institution | Kawasaki Medical School (2011) Kyushu University (2009-2010) |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
Keywords | 外科総論 / ペプチド / Patched1 / Hedgehog / 膵癌 / Sonic Hedgehog / Ptched1 / 乳癌 / 癌性幹細胞 |
Research Abstract |
The goal of the study is designing a peptide affinity for cancer-related molecule. To validate the anti-tumor effect, subject to the(Hh) signal Hedgehog, Small peptides with affinity for cell surface receptor Ptched1 were designated. Its effect on cancer cells were examined using breast and pancreatic cancer cells. We probed that synthesized peptides suppressed Hh signaling activity and cancer cell proliferation in vitro and vivo.
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Report
(4 results)
Research Products
(16 results)