Development of ultrasound and bubble-liposome-mediated drug delivery to ocular tissues
Project/Area Number |
21659400
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
|
Research Institution | Kagoshima University |
Principal Investigator |
SAKAMOTO Taiji 鹿児島大学, 医歯学総合研究科, 教授 (10235179)
|
Research Collaborator |
TACHIBANA Katsuro 福岡大学, 医学部, 教授
MARUYAMA Kazuo 帝京大学, 薬学部, 教授
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,140,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
Keywords | 超音波 / ナノバブル / リポソーム製剤 |
Research Abstract |
We developed a novel method to deliver genes or drugs to ocular tissues using ultrasound and bubble-liposome. GFP cDNA embedded in bubble-liposome was injected in the vitreous followed by irradiation of ultrasound. GFP was strongly expressed by retina where ultrasound was irradiated. Tissue damage was minimal. We also developed a new ultrasound probe for that.
|
Report
(4 results)
Research Products
(62 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] Vitrectomy for exudative age-related m acular degeneration with vitreous hemorrh age2010
Author(s)
Sakamoto T, Sheu SJ, Arimura N, Sames hima S, Shimura M, Uemura A, Kawano H, Wu TT, Kubota T, Sohma R, Noda Y.
-
Journal Title
Retina
Volume: 30(6)
Issue: 6
Pages: 856-864
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes2010
Author(s)
Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I.
-
Journal Title
J Immunol
Volume: 184(9)
Issue: 9
Pages: 4819-4826
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Vitrectomy for exudative age-related macular degeneration with vitreous hemorrhage.2010
Author(s)
Sakamoto T, Sheu SJ, Arimura N, Sameshima S, Shimura M, Uemura A, Kawano H, Wu TT, Kubota T, Sohma R, Noda Y.
-
Journal Title
Retina.
Volume: 30(6)
Pages: 856-864
Related Report
Peer Reviewed
-
[Journal Article] B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes.2010
Author(s)
Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I.
-
Journal Title
J Immunol.
Volume: 184(9)
Pages: 4819-4826
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] 眼内長期滞留ガス(SF6,C3F8)ガイドライン2010
Author(s)
大路正人, 小椋祐一郎, 坂本泰二, 白神史雄, 平形明人, 寺崎浩子, 東範行, 飯島裕幸, 飯田知弘, 池田恒彦, 石橋達朗, 岸章治, 竹内忍, 中澤満, 根木昭, 堀貞夫, 堀口正之, 松村美代, 山下英俊, 山本修一, 湯澤美都子, 吉田晃敏, 吉村長久
-
Journal Title
日本眼科学会雑誌
Volume: 114
Pages: 110-115
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] ガス下OCTの考察2011
Author(s)
坂本泰二
Organizer
Japan Macula Club第13回総会
Place of Presentation
蒲郡プリンスホテル(蒲郡市)
Year and Date
2011-08-20
Related Report
-
-
-
-
-
-
[Presentation] NSAIDs点眼による脈絡膜血管新生抑制2011
Author(s)
吉永就正, 有村昇, 大塚寛樹, 竹之内和則, 貞村ゆかり, 野間聖, 川原幸一, 園田祥三, 橋口照人, 丸山征郎, 坂本泰二
Organizer
第115回日本眼科学会総会
Place of Presentation
東京国際フォーラム(東京都)
Year and Date
2011-05-13
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-