Strategy for treatment of periodontitis with regulating exocytosis using functional bionano particle
| Project/Area Number |
21659436
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
MATSUSHITA Kenji 独立行政法人国立長寿医療研究センター, 口腔疾患研究部, 部長 (90253898)
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| Co-Investigator(Kenkyū-buntansha) |
EGUCHI Takanori 独立行政法人国立長寿医療研究センター, 口腔疾患研究部, 室長 (20457229)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,360,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | 免疫 / 感染 / 炎症 / 歯周病学 / 生体分子設計 / 低分子Gタンパク質 / 上皮機能 / 細胞骨格タンパク質 / エンドサイト-シス / 細胞内輸送 / 免疫・感染・炎症 / Porphyromonas gingivalis / インテグリン / セレクチン / エンドサイトーシス |
|---|
| Research Abstract |
We explored factors for intracellular vesicle trafficking in gingival epithelial cells and examined a possibility of the regulation. A small G-protein Rab5 and the associated protein vinculin were identified as important factors for vesicle trafficking in the cells. Rab5 and ICAM-1 were associated with uptake of Porphyromonas gingivals by the cells. Furthermore, we clarified that E-selectin is important for regulating endothelial exocytosis by stimulation with P. gingivalis.
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Report
(4 results)
Research Products
(87 results)
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[Presentation] E-selectin mediates Porphyromonas gingivalis adherence to endothelial cells2010
Author(s)
Komatsu T, Nagano K, Sugiura S, Hagiwara M, Tanigawa N, Eguchi T, Yoshimura F, Furuichi Y, Matsushita K
Organizer
The 96th Annual Meeting of American Academy of Periodontology
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-10-31
Related Report
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[Presentation] Valproic acid enhances innate immune response to LPS by HMGB1 release2010
Author(s)
Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Eguchi T, Mizutani H, Matsushita K, Noguchi T
Organizer
The 96th Annual Meeting of American Academy of Periodontology
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-10-31
Related Report
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[Presentation] E-selectin mediates Porphyromonas gingivalis adherence to endothelial cells.2010
Author(s)
Komatsu T, Nagano K, Sugiura S, Hagiwara M, Tanigawa N, Eguchi T, Yoshimura F, Furuichi Y, Matsushita K
Organizer
The 96th Annual Meeting of American Academy of Periodontology.
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-10-31
Related Report
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[Presentation] Valproic acid enhances innate immune response to LPS by HMGB1 release.2010
Author(s)
Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Eguchi T, Mizutani H, Matsushita K, Noguchi T
Organizer
The 96th Annual Meeting of American Academy of Periodontology
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-10-31
Related Report
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[Presentation] Valproic acid enhanced innate immune response induced by LPS through stimulating active release of HMGB1.2010
Author(s)
Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Mizutani H, Eguchi T, Kawahara K, Maruyama I, Noguchi T, Matsushita K
Organizer
第8回血液・血管オルビス
Place of Presentation
東京
Year and Date
2010-08-21
Related Report
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