| Project/Area Number |
21659436
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
MATSUSHITA Kenji 独立行政法人国立長寿医療研究センター, 口腔疾患研究部, 部長 (90253898)
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| Co-Investigator(Kenkyū-buntansha) |
EGUCHI Takanori 独立行政法人国立長寿医療研究センター, 口腔疾患研究部, 室長 (20457229)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,360,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥700,000 (Direct Cost: ¥700,000)
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|---|
| Keywords | 免疫 / 感染 / 炎症 / 歯周病学 / 生体分子設計 / 低分子Gタンパク質 / 上皮機能 / 細胞骨格タンパク質 / エンドサイト-シス / 細胞内輸送 / 免疫・感染・炎症 / Porphyromonas gingivalis / インテグリン / セレクチン / エンドサイトーシス |
|---|
| Research Abstract |
We explored factors for intracellular vesicle trafficking in gingival epithelial cells and examined a possibility of the regulation. A small G-protein Rab5 and the associated protein vinculin were identified as important factors for vesicle trafficking in the cells. Rab5 and ICAM-1 were associated with uptake of Porphyromonas gingivals by the cells. Furthermore, we clarified that E-selectin is important for regulating endothelial exocytosis by stimulation with P. gingivalis.
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