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Functional analysis of mechanical stress-induced microRNAs

Research Project

Project/Area Number 21680049
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionThe University of Tokyo

Principal Investigator

AKIMOTO Takayuki  The University of Tokyo, 大学院・医学系研究科, 講師 (00323460)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2009: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Keywords筋肉 / 運動 / 細胞内シクナル伝達 / 物理的ストレス / 転写調節 / スモールRNA / 骨格筋 / 関節軟骨 / メカニカルストレス / 物理刺激 / 細胞分化 / 組織成熟 / ノンコーディングRNA / マイクロRNA / 転写因子
Research Abstract

The aim of this study is to determine gene regulation related to physical exercise, especially focusing on post-transcriptional control due to mechanical stress-induced microRNA (miRNA)s. We first identified several mechanical stress-induced miRNAs by a comprehensive microarray analysis. Among them, we chose miR-23a to analyze with respect to its function in skeletal muscle by using cultured cells and experimental animals. We found that miR-23a inhibits skeletal muscle atrophy by suppressing the translation of two ubiquitin ligases, atrogin-1 and MuRF1 in their 3'UTR dependent manner.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Acute exercise activates local bioactive androgen metabolism in skeletal muscle.2010

    • Author(s)
      K.Aizawa, M.Iemitsu, S.Maeda, T.Otsuki, K.Sato, T.Ushida, N.Mesaki, T.Akimoto.
    • Journal Title

      Steroid 75(3)

      Pages: 219-223

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Mohawk homeobox gene plays a critical role in tendon differentiation by regulating type I collagen production.2010

    • Author(s)
      Y.Ito, N.Toriuchi, T.Yoshitaka, H.Ueno-Kudoh, T.Sato, S.Yokoyama, K.Nishida, T.Akimoto, M.Takahashi, S.Miyaki, H.Asahara.
    • Journal Title

      Proc Natl Acad Sci USA. 107(23)

      Pages: 10538-10542

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Mohawk homeobox gene plays a critical role in tendon differentiation by regulating type I collagen production.2010

    • Author(s)
      Y.Ito, N.Toriuchi, T.Yoshitaka, H.Ueno-Kudoh, T.Sato, S.Yokoyama, K.Nishida, T.Akimoto, M.Takahashi, S.Miyaki, H.Asahara.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 107 Pages: 10538-10542

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute exercise activates local bioactive androgen metabolism in skeletal muscle.2010

    • Author(s)
      K.Aizawa, M.Iemitsu, S.Maeda, T.Otsuki, K.Sato, T.Ushida, N.Mesaki, T.Akimoto
    • Journal Title

      Steroids

      Volume: 75 Pages: 219-223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training activates local bioactive androgen metabolism in skeletal muscle2010

    • Author(s)
      K.Aizawa, M.Iemitsu, S.Maeda, T.Otsuki, K.Sato, T.Ushida, N.Mesaki, T.Akimoto
    • Journal Title

      Steroids 75

      Pages: 219-223

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of acute hypoxia on metabolic and hormonal responses to resistance exercise2010

    • Author(s)
      M.Kon, T.Ikeda, T.Homma, T.Akimoto, Y.Suzuki, T.Kawahara
    • Journal Title

      Med Sci Sports Exerc (掲載確定(印刷中))

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endurance exercise training enhances local sex steroidogenesis in skeletal muscle.

    • Author(s)
      K.Aizawa, M.Iemitsu, S.Maeda, N.Mesaki, T.Ushida, T.Akimoto.
    • Journal Title

      Med Sci Sports Exerc,掲載確定

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 骨格筋における活性型アンドロゲン産生の調節機序2010

    • Author(s)
      相澤勝治, 和田正吾, 目崎登, 牛田多加志, 秋本崇之
    • Organizer
      第65回日本体力医学会学術総会
    • Place of Presentation
      千葉商科大学(千葉)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Translational suppression of atrophic regulators by miR-23a integrates resistance to skeletal muscle atrophy.2010

    • Author(s)
      S.Wada, Y.Kato, M.Okutsu, S.Miyaki, K.Suzuki, Z.Yan, S.Schiaffino, H.Asahara, T.Ushida, T.Akimoto.
    • Organizer
      European Muscle Conference
    • Place of Presentation
      Abano-Termae(Padova), Italy
    • Year and Date
      2010-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Translational suppressions of atrophic regulators by a microRNA integrate resistance against skeletal muscle atrophy2010

    • Author(s)
      S.Wada, Y.Kato, M.Okutsu, S.Miyaki, K.Suzuki, Z.Yan, S.Schiaffino, H.Asahara, T.Ushida, T.Akimoto
    • Organizer
      EMC 2010
    • Place of Presentation
      Padova, Italy
    • Year and Date
      2010-09-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] メカニカルストレスによるPGC-1αアイソフォームの発現2009

    • Author(s)
      秋本崇之, 和田正吾, 相澤勝治, 牛田多加志
    • Organizer
      第64回日本体力医学会学術総会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] マイクロRNAによる骨格筋の制御.ンポジウム10「The Myogenesis-遺伝子・細胞・組織から検討した骨格筋細胞の発生・分化・再生-」2009

    • Author(s)
      秋本崇之, 和田正吾, 加藤義雄, 浅原弘嗣, 牛田多加志
    • Organizer
      第64回日本体力医学会学術総会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] メカニカルストレスによるPGC-1αアイソフォームの発現2009

    • Author(s)
      秋本崇之, 和田正吾, 相澤勝治, 牛田多加志
    • Organizer
      日本体力医学会
    • Place of Presentation
      新潟, 朱鷺メッセ
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Book] 物理的刺激と軟骨細胞(運動器慢性疾患に対する運動療法)(分担執筆:黒澤尚編)2009

    • Author(s)
      秋本崇之, 牛田多加志
    • Publisher
      金原出版,東京
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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