Development ofhigh-resolution terahertz chemicalmicroscope and its application for imaging of micro-flow channels.

• Project/Area Number: 21686038
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Measurement engineering
• Research Institution: Okayama University
• Principal Investigator: KIWA Toshihiko Okayama University, 大学院・自然科学研究科, 准教授 (00379710)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
• Keywords: テラヘルツ波 / バイオ計測 / ケミカルポテンシャル計測 / マイクロTAS

Research Abstract

Micro-flow channels have been attracted by a lot of researchers as one of the useful tools for a novel bio-assay and/or next-generation medical treatment. In this study, we developed a terahertz chemical microscope (TCM) for visualize the distribution of the materials concentrations in the water solutions. The laminar flows in the channel were controlled by analyzing the TCM images of the micro-flow channels.

Research Products

• [Journal Article] Terahertz chemical microscope for label-free detection of protein complex (2010)
  • Author(s): Kiwa Toshihiko, Kondo Yousuke, Minam, Yuji, Kawayama Iwao, Tonouchi Masayoshi, Tsukada, Keiji
  • Journal Title: APL Vol.96, No.21 Pages: 211114-211114
  • Peer Reviewed
• [Journal Article] テラヘルツ波ケミカル顕微鏡による非標識バイオセンシング (2010)
  • Author(s): 紀和利彦
  • Journal Title: 月刊バイオインダストリー 2010年10月号(特集記事) Pages: 14-19
• [Journal Article] Measurements of pH in fluidic chip using a terahertz chemical microscope (2010)
  • Author(s): T. Kiwa, S.Oka, Y.Minami, I.Kawayama, M.Tonouchi, K.Tsukada
  • Journal Title: IEEJ Trans.SM. Vol.1, No.4 Pages: 221-224
  • NAID: 10025102628
  • Peer Reviewed
• [Journal Article] Terahertz chemical microscope for label-free detection of protein complex (2010)
  • Author(s): Kiwa Toshihiko, Kondo Yousuke, Minam, Yuji, Kawayama Iwao, Tonouchi Masayoshi, Tsukada, Keiji
  • Journal Title: APPLIED PHYSICS LETTERS Volume: 96 Pages: 211114-211114
  • Peer Reviewed
• [Journal Article] テラヘルツ波ケミカル顕微鏡による非標識バイオセンシン (2010)
  • Author(s): 紀和利彦
  • Journal Title: 月刊バイオインダストリー Volume: 10 Pages: 14-19
• [Journal Article] Redox Reaction Imaging using THz Chemical Microscope (2009)
  • Author(s): T.Kiwa, Y.Minami, I.Kawayama, M.Tonouchi, K.Tsukada
  • Journal Title: IEEE Conference Proc.34th International Conference on Infrared, Millimeter, and Terahertz Waves
• [Presentation] (2011)
  • Author(s): 紀和利彦
  • Organizer: 第2回テラテクビジネスセミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-01-12
• [Presentation] マイクロTAS観察に向けたテラヘルツ波ケミカル顕微鏡の開発 (2011)
  • Author(s): 紀和利彦
  • Organizer: 第2回 テラテクビジネスセミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-01-12
• [Presentation] テラヘルツ光の応用 (2010)
  • Author(s): 紀和利彦
  • Organizer: 第1回ディジタルオプティクス研究会
  • Place of Presentation: 島根(招待講演)
  • Year and Date: 2010-11-19
• [Presentation] テラヘルツ波ケミカル顕微鏡の高感度化にむけたダブルパルス検出法の開発 (2010)
  • Author(s): 天満陽, 近藤洋輔, 紀和利彦, 塚田啓二
  • Organizer: 応用物理学会 中国四国支部 2010年度 支部学術講演会
  • Place of Presentation: 高知
  • Year and Date: 2010-07-31
• [Presentation] テラヘルツ波ケミカル顕微鏡によるpH分布評価応用 (2010)
  • Author(s): 近藤洋輔, 橋本陽平, 天満陽, 紀和利彦, 塚田啓二
  • Organizer: 応用物理学会 中国四国支部 2010年度 支部学術講演会
  • Place of Presentation: 高知
  • Year and Date: 2010-07-31
• [Presentation] A Terahertz Chemical Microscope to Visualize pH Distribution (2010)
  • Author(s): Y.Kondo, Y.Minami, 紀和利彦, I.Kawayama, M.Tonouchi, K.Tsukada
  • Organizer: The 13th International Meeting on Chemical Sensors
  • Place of Presentation: Perth, Australia
  • Year and Date: 2010-07-12
• [Presentation] Chemical Imaging in m-TAS using Terahertz Pulses (2010)
  • Author(s): T. Kiwa, Y.Minami, Y.Kondo, I.Kawayama, M.Tonouchi, K.Tsukada
  • Organizer: The 13th International Meeting on Chemical Sensors
  • Place of Presentation: Perth, Australia
  • Year and Date: 2010-07-12
• [Presentation] テラヘルツ波ケミカル顕微鏡を用いた植物断面のpH分布イメージング (2010)
  • Author(s): 近藤洋輔, 南祐治, 紀和利彦, 川山巌, 斗内政吉, 塚田啓二
  • Organizer: 第57回応用物理関係連合講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-03-19
• [Presentation] テラヘルツ波ケミカル顕微鏡によるpHイメージン (2010)
  • Author(s): 紀和利彦、近藤洋輔、南裕治、川山巌、斗内政吉、塚田啓二
  • Organizer: 研究討論会「テラヘルツ電子デバイスの新展開」
  • Place of Presentation: 仙台
  • Year and Date: 2010-02-26
• [Presentation] Chemical Imaging of m-TAS using Terahertz Chemical Microscope (2010)
  • Author(s): Toshihiko Kiwa, Yuji Minami, Yusuke Kondo, Yohei Hashimoto, Iwao Kawayama, Masayoshi Tonouchi, Keiji Tsukada
  • Organizer: IEEE Conference Proc.35th International Conference on Infrared, Millimeter, and Terahertz Waves
  • Place of Presentation: Italy, Roma(招待Keynote講演)
• [Presentation] テラヘルツ波ケミカル顕微鏡のμ-TAS測定 (2010)
  • Author(s): 橋本陽平, 近藤洋輔, 紀和利彦, 川山巌, 斗内政吉, 塚田啓
  • Organizer: 応用物理学会2010年秋季学術講演
  • Place of Presentation: 長崎
• [Presentation] Terahertz chemical microscope for bio-sensing tool (2009)
  • Author(s): T.Kiwa, Y.Minami, Y.Kondo, K.Tsukada, I.Kawayama, M.Tonouchi
  • Organizer: 2nd International Workshop on Terahertz Technology
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-12-03
• [Presentation] Terahertz chemical microscope for bio-sensing tool (2009)
  • Author(s): 紀和利彦, Y.Minami, Y.Kondo, K.Tsukada, I.Kawayama, M.Tonouchi
  • Organizer: 2nd International Workshop on Terahertz Technology
  • Place of Presentation: Osaka, Japan(招待講演)
  • Year and Date: 2009-12-02
• [Presentation] A Terahertz chemical microscope to detect avidin-biotin bonds (2009)
  • Author(s): Y.Kondo, Y.Minami, 紀和利彦, I.Kawayama, M.Tonouchi, K.Tsukada
  • Organizer: 2nd International Workshop on Terahertz Technology
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-12-02
• [Presentation] Redox Reaction Imaging in the Micro-total Analysis System using Terahertz Chemical Microscope (2009)
  • Author(s): Y.Minami, Y.Kondo, T. Kiwa, I.Kawayama, M.Tonouchi, K.Tsukada
  • Organizer: 2nd International Workshop on Terahertz Technology
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-12-02
• [Presentation] Redox Reaction Imaging using THz Chemical Microscope, IEEE Conference Proc. (2009)
  • Author(s): 紀和利彦, Y.Minami, I.Kawayama, M.Tonouchi, K.Tsukada
  • Organizer: 34th International Conference on Infrared, Millimeter, and Terahertz Waves
  • Place of Presentation: Busan, Korea(招待講演)
  • Year and Date: 2009-09-25
• [Presentation] Evaluation of the Catalytic Metal for the Hydrogen Sensor using Terahertz Chemical Microscope, IEEE Conference Proc. (2009)
  • Author(s): T.Sugimoto, Y.Kondo, T. Kiwa, I.Kawayama, M.Tonouchi, K.Tsukada
  • Organizer: 34th International Conference on Infrared, Millimeter, and Terahertz Waves
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-09-23
• [Presentation] Redox Reaction Imaging using THz Chemical Microscope (2009)
  • Author(s): T.Kiwa, Y.Minami, I.Kawayama, M.Tonouchi, K. Toukodo
  • Organizer: 34th International Conference on Infrared, Millimeter, and Terahertz Waves
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-09-21
• [Presentation] テラヘルツ波ケミカル顕微鏡を用いたアビジンービオチン結合の検出 (2009)
  • Author(s): 近藤洋輔, 南祐治, 紀和利彦, 川山巌, 斗内政吉, 塚田啓二
  • Organizer: 応用物理学会2009年秋季学術講演
  • Place of Presentation: 富山
  • Year and Date: 2009-09-09
• [Presentation] Chemical Imaging of m-TAS using Terahertz Chemical Microscope,IEEE Conference Proc. (2009)
  • Author(s): T. Kiwa, Yuji Minami, Yusuke Kondo, Yohei Hashimoto, Iwao Kawayama, Masayoshi Tonouchi, Keiji Tsukada
  • Organizer: 35th International Conference on Infrared, Millimeter, and Terahertz Waves
  • Place of Presentation: Rome, Italy(招待講演)
  • Year and Date: 2009-09-07
• [Book] テラヘルツ波新産業 (2011)
  • Author(s): 斗内政吉監修, 紀和利彦, 他著
  • Publisher: シーエムシー出版
• [Remarks] Nature asia-pasificのwebサイトの記事
  • URL: http://www.natureasia.com/asia-materials/highlight.php?id=736
• [Remarks] 科学雑誌での取材記事Nature Photoniccs誌(Vol.4, p.276(2010))
• [Remarks] ホームページ等
  • URL: http://www.sense.elec.okayama-u.ac.jp/pages/research/thz_j.html
• [Remarks]
  • URL: http://www.sense.elec.okayama-u.ac.jp/pages/research/thz_j.html