Analysis of novel functions of microtubules that bridge meiotic recombination and chromosome segregation

• Project/Area Number: 21687015
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: The University of Tokyo
• Principal Investigator: SATO Masamitsu 東京大学, 大学院・理学系研究科, 助教 (50447356)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000); Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 細胞分裂 / 細胞周期 / 染色体分配 / 微小管 / 減数分裂組換え / 遺伝学 / 遺伝子 / ゲノム / 発生・分化 / 染色体 / 細胞

Research Abstract

We focused on a novel microtubule array that is seen in fission yeast meiosis, and verified that the microtubule array play a role in relaying meiotic recombination and meiotic chromosome segregation. We also investigated the molecular mechanism how the array is formed.

Research Products

• [Journal Article] SPB components are reorganized during fission yeast meiosis. (2012)
  • Author(s): Midori Ohta
  • Journal Title: Molecular Biology of the Cell Volume: 23 Issue: 10 Pages: 1799-1811
  • DOI: 10.1091/mbc.e11-11-0951
  • Peer Reviewed
• [Journal Article] Interpolar microtubules are dispensable in fission yeast meiosis II (2012)
  • Author(s): T. Akera, M. Sato and M. Yamamoto
  • Journal Title: Nat. Commun Volume: 3 Issue: 1 Pages: 695-695
  • DOI: 10.1038/ncomms1725
  • Peer Reviewed
• [Journal Article] SCF ensures meiotic chromosome segregation through a resolution of meiotic recombination intermediates (2012)
  • Author(s): S. Okamoto, M. Sato, T. Toda and M. Yamamoto
  • Journal Title: PLoS One Volume: 7 Issue: 1 Pages: 30622-30622
  • DOI: 10.1371/journal.pone.0030622
  • Peer Reviewed
• [Journal Article] A novel fission yeast mei4 mutant that allows efficient synchronization of telomere dispersal and the first meiotic division (2011)
  • Author(s): Yasutaka Kakui, Masamitsu Sato, Kayoko Tanaka and Masayuki Yamamoto
  • Journal Title: Yeast Volume: 28 Issue: 6 Pages: 467-479
  • DOI: 10.1002/yea.1851
  • Peer Reviewed
• [Journal Article] A novel fission yeast mei4 mutant that allows efficient synchronization of telomere dispersal and the first meiotic division (2011)
  • Author(s): Yasutaka Kakui
  • Journal Title: Yeast Volume: (オンライン版)
  • Peer Reviewed
• [Journal Article] Nuclear compartmentalization is abolished during fission yeast meiosis (2010)
  • Author(s): Kunio Arai, Masamitsu Sato, Kayoko Tanaka and Masayuki Yamamoto
  • Journal Title: Current Biology Volume: 9 Issue: 21 Pages: 1913-1918
  • DOI: 10.1016/j.cub.2010.09.004
  • Peer Reviewed
• [Journal Article] Fission yeast Pcp1 links polo kinase-mediated mitotic entry toγ-tubulin-dependent spindle formation (2010)
  • Author(s): Chii Shyang Fong, Masamitsu Sato and Takashi Toda
  • Journal Title: EMBO Journal Volume: 29 Issue: 1 Pages: 120-130
  • DOI: 10.1038/emboj.2009.331
  • Peer Reviewed
• [Journal Article] Fission yeast Pcpl links polo kinase-mediated mitotic entry to γ-tubulin-dependent spindle formation (2010)
  • Author(s): Chii Shyang Fong
  • Journal Title: EMBO Journal 29 Pages: 120-130
  • Peer Reviewed
• [Journal Article] Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast (2009)
  • Author(s): Masamitsu Sato, Naoyiki Okada, Yasutaka Kakui, Masayuki Yamamoto, Minoru Yoshida and Takashi Toda
  • Journal Title: EMBO reports Volume: 10 Issue: 10 Pages: 1161-1167
  • DOI: 10.1038/embor.2009.158
  • Peer Reviewed
• [Journal Article] Nucleocytoplasmic transport of Alp7/TACC organizes spatiotem poral microtubule formation in fission yeast (2009)
  • Author(s): Masamitsu Sato
  • Journal Title: EMBO reports 10 Pages: 1161-1167
  • Peer Reviewed
• [Presentation] How is interpolar microtubule regulated (2011)
  • Author(s): 佐藤政充
  • Organizer: The 6th International Fission Yeast Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2011-06-27
• [Presentation] How is interpolar microtubule regulated? (2011)
  • Author(s): Masamitsu Sato
  • Organizer: The 6th International Fission Yeast Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2011-06-27
• [Presentation] How are microtubules reorganised upon entry into mitosis and meiosis in fission yeast (2011)
  • Author(s): 佐藤政充
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: Windermere, UK
  • Year and Date: 2011-04-12
• [Presentation] How are microtubules reorganised upon entry into mitosis and meiosis in fission yeast? (2011)
  • Author(s): Masamitsu Sato
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: Windermere, UK
  • Year and Date: 2011-04-12
• [Presentation] REGULATION OF SPINDLE MICROTUBULES IN MITOSIS AND MEIOSIS (2010)
  • Author(s): 佐藤政充
  • Organizer: The 5th International Fission Yeast Meeting
  • Place of Presentation: 代々木
  • Year and Date: 2010-10-29
• [Presentation] Microtubule reorganisation upon entry into Mitosis and Meiosis in fission yeast EMBO conference (2010)
  • Author(s): 佐藤政充
  • Organizer: Microtubules
  • Place of Presentation: ドイツ、EMBL
• [Presentation] Meiosis-specific behaviour of microtubules, kinetochores and spindle pole bodies in fission yeast (2010)
  • Author(s): 佐藤政充
  • Organizer: 日本細胞生物学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 染色体分配における分裂酵母CDKの役割染色体ワークショップ (2010)
  • Author(s): 佐藤政充
  • Place of Presentation: 御殿場高原ホテルB. U.
• [Presentation] 染色体分配における分裂酵母CDKの役割 (2010)
  • Author(s): 佐藤政充
  • Organizer: 染色体ワークショップ
  • Place of Presentation: 御殿場高原ホテルB.U.
• [Presentation] Meiosis-specific behaviour of microtubules, kinetochores and spindle polebodies in fission yeast (2010)
  • Author(s): 佐藤政充
  • Organizer: 日本細胞生物学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Microtubule reorganisation upon entry into Mitosis and Meiosis in fission yeast (2010)
  • Author(s): 佐藤政充
  • Organizer: EMBO conference, Microtubules
  • Place of Presentation: ドイツ、ハイデルベルク、欧州分子生物学研究所
• [Presentation] Regulation of Microtubule Formation in Fission Yeast Mitosis and Meiosis (2009)
  • Author(s): 佐藤政充
  • Organizer: International Symposium : Chromosome Segregation Machinery
  • Place of Presentation: 癌研究会癌研究所
  • Year and Date: 2009-06-05
• [Presentation] Nuclear microtubule formation and chromosomal behaviours in fission yeast meiosis (2009)
  • Author(s): 佐藤政充
  • Organizer: 日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-06-04
• [Remarks]
  • URL: http://msmicrotubule.blogspot.com/
• [Remarks]
  • URL: http://msmicrotubule.blogspot.jp/
• [Remarks] 微小管ブログ
  • URL: http://msmicrotubule.blogspot.com/
• [Remarks]
  • URL: http://msmicrotubule.blogspot.com/