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Genetic anthropology of the blood lipid level

Research Project

Project/Area Number 21687021
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Physical anthropology
Research InstitutionJichi Medical University

Principal Investigator

NAKAYAMA Kazuhiro  Jichi Medical University, 医学部, 助教 (90433581)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords遺伝子 / 多型 / 人類 / 進化 / 中性脂肪 / コレステロール / 人類学 / 遺伝学 / 脂質 / ゲノム
Research Abstract

To elucidate anthropological significance of genetic variation for blood lipid level in humans, over 20,000 individuals from 5 Asian and Oceanian groups were investigated for common and rare variants of lipid associated genes. 1) Effects of FADS (fatty acid desaturase) gene variants on blood lipid level were dramatically varied between Mongolians and Japanese. Differences in dietary intake of unsaturated fatty acid would explain the variation in phenotypic effects of the FADS gene variants. 2) Anti-hypertriglyceridemic MLXIPL Gln241His variant was found with high frequencies in central Asians who can be traced back to nomadic pastoralists. Gln241His variant might have been significant for utilization of carbohydrates and fats in nomadic pastoralists. 3) Resequencing of Scavenger receptor class B gene family revealed excess of rare variants among Thai individuals. This suggested a possible link between genetic variation of lipid metabolism and malaria resistance. 4) Additionally, the present study showed that in an association study of blood lipid level, adjustment for visceral fat accumulation can improve sensitivity of detecting effects of genetic variants.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 6 results) Presentation (21 results)

  • [Journal Article] Jichi Medical University Promotion Team of a Large-scale Human Genome Bank for All over Japan A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.2010

    • Author(s)
      Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S
    • Journal Title

      Human Genetics. 127

      Pages: 685-690

    • Related Report
      2010 Final Research Report
  • [Journal Article] Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macaques.2010

    • Author(s)
      Nakayama K, Shotake T, Takenaka O, Ishida T
    • Journal Title

      Journal of Mammalian Evolution 17

      Pages: 211-214

    • Related Report
      2010 Final Research Report
  • [Journal Article] A preliminary study on the effects of visceral fat accumation on plasma lipid concentration and the lipid associated SNPs in Japanese.2010

    • Author(s)
      Ogawa Y, Nakayama K, Yanagisawa Y, Gotoh T, Yamanaka Y, Iwamoto S, Miyashita H
    • Journal Title

      DNA polymorphism 18

      Pages: 246-249

    • Related Report
      2010 Final Research Report
  • [Journal Article] Anthropological insights into the genetic diversity of MLXIPL (2010)2010

    • Author(s)
      Nakayama K, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa Y, Iwamoto S, Mukhtulga L, Koda Y, Ishida T, Kagawa Y
    • Journal Title

      DNA polymorphism

      Pages: 237-241

    • Related Report
      2010 Final Research Report
  • [Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI.2010

    • Author(s)
      Munkhtulga L, Nagashima S, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, Iwamoto S
    • Journal Title

      Obesity (Silver Spring). 18

      Pages: 1006-1014

    • Related Report
      2010 Final Research Report
  • [Journal Article] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle2010

    • Author(s)
      Nakayama K
    • Journal Title

      Human Genetics

      Volume: 127 Pages: 685-690

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macayues.2010

    • Author(s)
      Nakayama K
    • Journal Title

      Journal Mammalian Evolution

      Volume: 17 Pages: 211-214

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI.2010

    • Author(s)
      Munkhtulga L
    • Journal Title

      Obesity (Silver Spring).

      Volume: 18 Pages: 1006-1014

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脂質代謝に関わる転写因子MLXIPLの遺伝的多様性とその人類生物学的意義2010

    • Author(s)
      中山一大
    • Journal Title

      DNA多型

      Volume: 18 Pages: 237-241

    • NAID

      10029668362

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 日本人内臓脂肪ゲノムバンクを用いた血清脂質関連遺伝子多型の検証2010

    • Author(s)
      小川歩美
    • Journal Title

      DNA多型

      Volume: 18 Pages: 246-249

    • Related Report
      2010 Annual Research Report
  • [Journal Article] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asianethnic groups with distinctive differences in lifestyle.2010

    • Author(s)
      Nakayama K
    • Journal Title

      Human Genetics Advance online publication

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Jichi Community Genetics Team (JCOG) Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.2009

    • Author(s)
      Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S
    • Journal Title

      Journal of Medical Genetics 46

      Pages: 370-374

    • Related Report
      2010 Final Research Report
  • [Journal Article] Large scale replication analysis of loci associated with lipidconcentrations in a Japanese population2009

    • Author(s)
      Nakayama K
    • Journal Title

      Journal of Medical Genetics 46

      Pages: 370-374

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory SNP in the RBP4 Gene Modified the Expression in Adipocytes and Associated With BMI2009

    • Author(s)
      Munkhtulga L
    • Journal Title

      Obesity (Silver Spring) Advance online publication

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 撓骨動脈トノメトリ波形解析から得られる血管年齢指標の検討2010

    • Author(s)
      宮下洋
    • Organizer
      第22回血圧管理研究会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Association study of polymorphisms in CTXN3 gene with schizophrenia in Thai population2010

    • Author(s)
      Panichareon B
    • Organizer
      DNA多型学会第19回学術集会
    • Place of Presentation
      三島市
    • Related Report
      2010 Final Research Report
  • [Presentation] 高脂血症感受性遺伝子TRIB1は高血圧とも関連する2010

    • Author(s)
      石塚裕美
    • Organizer
      DNA多型学会第19回学術集会
    • Place of Presentation
      三島市
    • Related Report
      2010 Final Research Report
  • [Presentation] Resequencing of human type B scavenger receptor genes in Asia-Pacific populations2010

    • Author(s)
      Kazuhiro Nakayama
    • Organizer
      The American Society of Human Genetics 60^<th> annual meeting
    • Place of Presentation
      Washington, DC
    • Related Report
      2010 Final Research Report
  • [Presentation] アジア・オセアニアにおけるスカベンジャー受容体ファミリー遺伝子の多様性2010

    • Author(s)
      中山一大
    • Organizer
      第64回日本人類学会大会
    • Place of Presentation
      伊達市
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖感受性エレメントのTRIB1遺伝子脂質異常症関連領域へのマッピングと遺伝子機能解析2010

    • Author(s)
      岩本禎彦
    • Organizer
      第17回日本遺伝子診療学会大会
    • Place of Presentation
      津市
    • Related Report
      2010 Final Research Report
  • [Presentation] Resequencing of human type B scavenger receptor genes in Asia-Pacific populations2010

    • Author(s)
      Nakayama K
    • Organizer
      The American Society of Human Genetics 60^<th> annual meeting
    • Place of Presentation
      Washington, DC (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖感受性エレメントのTRIB1遺伝子脂質異常症関連領域へのマッピングと遺伝子機能解析2010

    • Author(s)
      岩本禎彦
    • Organizer
      第17回日本遺伝子診療学会大会
    • Place of Presentation
      三重県津市
    • Related Report
      2010 Annual Research Report
  • [Presentation] アジア・オセアニアにおけるスカベンジャー受容体ファミリー遺伝子の多様性2010

    • Author(s)
      中山一大
    • Organizer
      第64回日本人類学会大会
    • Place of Presentation
      北海道伊達市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高脂血症感受性遺伝子TRIB1は高血圧とも関連する2010

    • Author(s)
      石塚裕美
    • Organizer
      DNA多型学会第19回学術集会
    • Place of Presentation
      静岡県三島市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association study of polymorphisms in CTXN3 gene with schizophrenia in Thai population2010

    • Author(s)
      Panichareon B
    • Organizer
      DNA多型学会第19回学術集会
    • Place of Presentation
      静岡県三島市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本人内臓脂肪ゲノムバンクを用いた血清脂質量関連多型の検証2009

    • Author(s)
      小川歩美
    • Organizer
      日本DNA多型学会第18回学術集会
    • Place of Presentation
      久留米市
    • Year and Date
      2009-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂質代謝に関わる転写因子MLXIPLの遺伝的多様性とその人類生物学的意義2009

    • Author(s)
      中山一大
    • Organizer
      日本DNA多型学会第18回学術集会
    • Place of Presentation
      久留米市
    • Year and Date
      2009-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂質代謝に関わる転写因子MLXIPLの遺伝的多様性とその人類生物学的意義2009

    • Author(s)
      中山一大
    • Organizer
      日本DNA多型学会第18回学術集会
    • Place of Presentation
      久留米大学医学部、久留米市
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト脂質異常症と関連するMLXIPL遺伝子の多様性とその人類学的意義2009

    • Author(s)
      中山一大
    • Organizer
      第63回日本人類学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-03
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト脂質異常症と関連するMLXIPL遺伝子の多様性とその人類学的意義2009

    • Author(s)
      中山一大
    • Organizer
      第36回日本人類学会大会
    • Place of Presentation
      シェーンバッハ・サボー、東京都
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] アジア人集団におけるFADS1/FADS2およびABCG5/ABCG8遺伝子多型の血清脂質量への寄与の検討2009

    • Author(s)
      中山一大
    • Organizer
      第16回日本遺伝子診療学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] アジア人集団におけるFADS1/FADS2およびABCG5/ABCG8遺伝子多型の血清脂質量への寄与の検討2009

    • Author(s)
      中山一大
    • Organizer
      第16回日本遺伝子診療学会大会
    • Place of Presentation
      ホテル札幌ガーデンパレス、札幌市
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evolutionary insights into a common genetic variant for dyslipidemia, Gln241His variant of MLXIPL2009

    • Author(s)
      Kazuhiro NAKAYAMA
    • Organizer
      The American Society of Human Genetics 59^<th> Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Large scale association analysis of SNPs associated with lipid concentrations in 21,010 Japanese individuals.2009

    • Author(s)
      Kazuhiro NAKAYAMA
    • Organizer
      European Human Genetics Conference 2009
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2010 Final Research Report
  • [Presentation] Large scale association analysis of SNPs associated with lipid concentrations in 21,010 Japanese individuals2009

    • Author(s)
      Kazuhiro NAKAYAMA
    • Organizer
      European Human Genetics Conference 2009
    • Place of Presentation
      Austria Center Vienna, Austrina
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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