Genome mining and microbial production of secondary metabolites
Project/Area Number |
21688009
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
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Research Institution | University of Shizuoka (2010-2011) The University of Tokyo (2009) |
Principal Investigator |
FUNA Nobutaka 静岡県立大学, 食品栄養科学部, 准教授 (70361574)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
|
Keywords | ポリケタイド / III型ポリケタイド合成酵素 / クルクミン / Streptomyces / Oryza sativa / アルキルレゾルシノール / ウコン / 放線菌 |
Research Abstract |
Genome mining is an innovative approach to isolating novel natural products by utilizing the genome data of bacteria, fungi, and plants. We characterized novel type I and type III polyketide synthases by genome mining studies of Streptomyces, Aspergillus, and Oryza sativa. We manipulated polyketide biosynthesis to generate libraries of "unnatural" natural products by microorganisms.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli2010
Author(s)
Katsuyama, Y., Hirose, Y., Funa, N., Ohnishi, Y., and Horinouchi, S
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 74
Issue: 3
Pages: 641-645
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] Physically discreteβ-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase2009
Author(s)
Awakawa, T., Yokota, K., Funa, N., Doi, F., Mort, N., Watanabe, H., and Horinouchi, S
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Journal Title
Chem. Biol
Volume: 16
Issue: 6
Pages: 613-623
DOI
Related Report
Peer Reviewed
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