| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Research Abstract |
Overproduction of saturated fatty acids is considered to be a molecular basis of the metabolic syndrome. In this study, we focused on the intimate crosstalk between adipocytes and macrophages in obese adipose tissue and identified ATF3, an anti-inflammatory transcriptionfactor, and Mincle, a pathogen sensor for mycobacterium tuberculosis, as novel regulators of adipose tissue inflammation. Thus, saturated fatty acids, which are released abundantly from hypertrophied adipocytes in obesity, may induce inflammatory changes in adipose tissue as well as lipotoxicity in remote organs such as liver and skeletal muscle.
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