Evolutionary simulation of gene regulatory networks based on comprehensive transcriptome and mutation analysis.
| Project/Area Number |
21700324
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bioinformatics/Life informatics
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
ONO Naoaki Osaka University, 大学院・情報科学研究科, 特任准教授 (60395118)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | マイクロアレイ / 遺伝子 / 発現制御 / モデル化 / 数理生物学 / 遺伝子発現解析 / DNAマイクロアレイ / 実験室進化 / 変異解析 |
|---|
| Research Abstract |
Based on expression profiles of Escherichia coli stains which were evolved under an ethanol stress condition in laboratory, we sequenced the whole genomes and expression profiles. Though there were no common mutations, we observed a bias of expression changes shared by the adapted strains. We modeled the dynamics of gene regulatory networks to simulate their adaptation, and we evaluated the effect of changes in global regulatory genes.
|
Report
(3 results)
Research Products
(36 results)
-
-
-
[Journal Article] Transition from positive to neutral in mutation fixation along with continuing rising fitness in thermal adaptive evolution.2010
Author(s)
Toshihiko Kishimoto, Leo Iijima, Makoto Tatsumi, Naoaki Ono, Ayana Oyake, Tomomi Hashimoto, Moe Matsuo, Masato Okubo, Shingo Suzuki, Kotaro Mori, Akiko Kashiwagi, Chikara Furusawa, Bei-Wen Ying, Tetsuya Yomo
-
Journal Title
Related Report
Peer Reviewed
-
-
[Journal Article] Genome-wide mutational and expression analysis of evolved Escherichia coli strains under ethanol stress.2009
Author(s)
Horinouchi, T., Tamaoka, K., Furusawa, C., Hirasawa, T., Ono, N., Suzuki, S., Yomo, T., Shimizu, H.
-
Journal Title
Proc. of the 20th International Conference on Genome Informatics (GIW 2009)
Related Report
Peer Reviewed
-
-
[Journal Article] Genome-wide mutational and expression analysis of ethanol-tolerant Escherichia coli.2009
Author(s)
Horinouchi, T., Tamaoka, K., Furusawa, C., Hirasawa, T., Ono, N., Suzuki, S., Yomo, T., Shimizu, H.
-
Journal Title
Proc. of the International Symposium on Complex Systems Biology
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
