Search for an aberrant splicing associated with schizophrenia specific antigen

• Project/Area Number: 21700385
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Fujita Health University
• Principal Investigator: MANABE Takayuki Fujita Health University, 総合医科学研究所, 講師 (90382283)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 統合失調症 / リンパ芽球 / スクリーニング

Research Abstract

This research topic has aimed the comparative study of the difference of the production style of antibodies between the normal and the schizophrenia patients using the lymphoblastoid cell lines obtained from both groups. By this research topic, it has been demonstrated that the selectivity of J1-3 and J7 are different from the normal control in schizophrenia.

Research Products

• [Journal Article] Altering the expression balance of hnRNP C1 and C2 changes the expression of myelination-ewlated genes. (2011)
  • Author(s): Iwata K., Matsuzaki H., Manabe T., Mori N.
  • Journal Title: Psychiat.Res. in press
  • Peer Reviewed
• [Journal Article] Aberrant regulation of alternative splicing in Schizophrenia. (2010)
  • Author(s): Morikawa T., Manabe T.
  • Journal Title: Neurochem.Int. 57 Pages: 691-704
  • Peer Reviewed
• [Journal Article] Animal models of autism : an epigenetic and environmental viewpoint. (2010)
  • Author(s): Iwata K., Matsuzaki H., Takei N., Manabe T., Mori N.
  • Journal Title: Journal of Central Nervous System Disease 2 Pages: 37-44
  • Peer Reviewed
• [Journal Article] The expression of HMGA1a is increased in lymphoblastoid cell lines from Schizophrenia patients. (2010)
  • Author(s): Morikawa T., Manabe T., Ito Y., Yamada S., Yoshimi A., Nagai T., Ozaki N., Mayeda A.
  • Journal Title: Neurochem.Int. 56 Pages: 736-739
  • Peer Reviewed
• [Journal Article] Regulation and/or Repression of Cholinergic Differentiation of Murine Embryonic Stem Cells using RNAi Against Transcription Factor L3/Lhx8. (2010)
  • Author(s): Manabe T., Wanaka A.
  • Journal Title: Methods Mol.Biol. 650 Pages: 101-109
• [Journal Article] Transient activation of Notch signaling in the injured adult brain. (2010)
  • Author(s): Tatsumi K., Okuda H., Makinodan M., Yamauchi T., Makinodan E., Matsuyoshi H., Manabe T., Wanaka A.
  • Journal Title: J.Chem.Neuroanat. 39 Pages: 15-19
  • Peer Reviewed
• [Journal Article] Aberrant regulation of alternative pre-mRNA splicing in Schizophrenia (2010)
  • Author(s): Morikawa T., Manabe T.
  • Journal Title: Neurochemistry International Volume: 57 Pages: 691-704
  • Peer Reviewed
• [Journal Article] Animal models of autism : an epigenetic and environmental view point. (2010)
  • Author(s): Iwata K., Matsuzaki S., Takei N, Manabe T., Mori N.
  • Journal Title: Journal of Central Nervouse System Disease Volume: 2 Pages: 1-8
  • Peer Reviewed
• [Journal Article] The expression of HMGA1a is increased in lymphoblastoid cell lines from Schizophrenia patients (2010)
  • Author(s): Morikawa T., Manabe T., Ito Y., Yamada S., Yoshimi A., Nagai T., Ozaki N., Mayeda A.
  • Journal Title: Neurochem.Int. (印刷中)
  • Peer Reviewed
• [Journal Article] Transient activation of Notch signaling in the injured adult brain (2010)
  • Author(s): Tatsumi K., Okuda H., Makinodan M., Yamauchi T., Makinodan E., Matsuyoshi H., Manabe T., Wanaka A.
  • Journal Title: J.Chem.Neuroanat. 39 Pages: 15-19
  • Peer Reviewed
• [Journal Article] The HMGA1a recognition candidate DNA sequencesin human. (2009)
  • Author(s): Manabe T., Katayama T., Tohyama M.
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Journal Article] Oncogenic HMGA1a protein causes Sporadic Alzheimer's disease-associated aberrant splicing : The molecular mechanism reveals a link with U1 snRNP-mediated gene repression system. (2009)
  • Author(s): Mayeda A., Manabe T., Ohe K.
  • Journal Title: Protein, Nucleic Acid, Enzyme. 54 Pages: 2245-2250
• [Journal Article] The HMGA1a recognition candidate DNA sequences inhuman (2009)
  • Author(s): Manabe T., Katayama T., Tohyama M.
  • Journal Title: PLoS One. 4
  • Peer Reviewed
• [Presentation] 統合失調症患者で転写・スプライシング調節因子であるHMGA1aが上昇している意義 (2010)
  • Author(s): 眞部孝幸、森川智美、山下祐子、前田明
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] 統合失調症患者で転写・スプライシング調節因子であるHMGA1aが上昇している意義 (2010)
  • Author(s): 眞部孝幸、森川智美、山下祐子、前田明
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-12-08
• [Presentation] 統合失調症患者におけるhnRNP A1 による異常スプライシング (2009)
  • Author(s): 眞部孝幸、前田明
  • Organizer: 第32回分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] 統合失調症患者におけるhnRNP A1による異常スプライシング (2009)
  • Author(s): 眞部孝幸、前田明
  • Organizer: 第32回分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] 統合失調症と異常スプライシング (2009)
  • Author(s): 眞部孝幸、前田明
  • Organizer: 第69回日本解剖学会中部支部大会
  • Place of Presentation: 浜松
  • Year and Date: 2009-10-10
• [Presentation] 腸管神経堤細胞の移動様式 (2009)
  • Author(s): 榎本秀樹、西山千尋、眞部考幸、Heather Young、Don Newgreen.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] 統合失調症の異常スプライシングにグローバルなスプライシング抑制因子であるhnRNP A1が関与している可能性を探る (2009)
  • Author(s): 眞部孝幸、前田明
  • Organizer: 第11回日本RNA学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-07-28
• [Book] Methods Mol.Biol. (2010)
  • Author(s): Manabe T., Wanaka A.
  • Publisher: Regulation and/or Repression of Cholinergic Differentiation of Murine Embryonic Stem Cells using RNAi Against Transcription Factor L3/Lhx8(印刷中)
• [Book] Protein, Nucleic Acid, Enzyme. (2009)
  • Author(s): Mayeda A., Manabe T., Ohe K.
  • Total Pages: 6
  • Publisher: Oncogenic HMGA1a protein causes Sporadic Alzheimer's disease-associated aberrant splicing : The molecular mechanism reveals a link with U1 snRNP-mediated gene repression system