| Project/Area Number |
21700396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Juntendo University |
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Principal Investigator |
KASHIYAMA Taku Juntendo University, 医学部, 助教 (90338343)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 神経変性疾患 / アミロイドベータ / アルツハイマー / αセクレターゼ / BACE1 / アミロイドβ / PKC |
|---|
| Research Abstract |
Amyloid-beta (Ass), which plays a major role in Alzheimer disease, is generated by ss and _Y cleavage of Amyloid precursor protein (APP). While ss cleavage, which occur within A_Y, competitively reduces Ass production. Therefore, acceleration of α cleavage may be one of the therapeutic strategies for Alzheimer disease. To determine a cleavage mechanism specific for APP, we developed a tool for analyzing cleavage mechanism in other substrates, which is also cleaved by α-and ss-secretase.
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