Electrophysiological cardiac evaluation by magnetocardiography in nonhuman primates

• Project/Area Number: 21700444
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Institute of Biomedical Innovation
• Principal Investigator: AGEYAMA Naohide 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 主任研究員 (50399458)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心臓興奮 / 伝導異常 / 医療・福祉 / 循環器・高血圧 / トランスレーショナルリサーチ / 生理学 / 動物 / 心臓興奮・伝導異常

Research Abstract

In this study, electrophysiological cardiac evaluation systems based on noninvasive and highly sensitive magnetocardiography techniques that can evaluate nonhuman primate cardiovascular disease will lead to novel models of safety assessment. Moreover, systems based on MCG that can evaluate non-human primate models of arrhythmias will lead to novel diagnoses of human conditions and elucidate the electrophysiological mechanisms in cardiology.

Research Products

• [Journal Article] 霊長類の循環器疾患とモデル動物開発 (2011)
  • Author(s): 揚山直英
  • Journal Title: 関西実験動物研究会会報 Volume: 33号 Pages: 14-21
  • URL: http://www.anim.med.kyoto-u.ac.jp/kansai/kansai_web_new/Contents%20of%20Proceedings_1.htm
• [Presentation] Rare Cardiac Disease Cases in Four Cynomolgus Monkeys(Macaca fascicularis) (2011)
  • Author(s): Hiroshi Koie, Takashi Ikegawa, Sachi Okabayashi, Kiichi Kanayama, Tadashi Sankai, Yasuhiro Yasutomi, Naohide Ageyama
  • Organizer: 62^<nd> American Association for Laboratory Animal Science National Meeting
  • Place of Presentation: San Diego Convention Center(San Diego, CA, USA)
  • Year and Date: 2011-10-03
• [Presentation] Assessment of QTc reference values in cynomolgus monkeys with arrhythmia (2011)
  • Author(s): Naohide Ageyama, Hiroshi Koie, Miyoko Kato, Yasuhiro Yasutomi
  • Organizer: 62^<nd> American Association for Laboratory Animal Science National Meeting
  • Place of Presentation: San Diego Convention Center(San Diego, CA, USA)
  • Year and Date: 2011-10-03
• [Presentation] Assessment of QTc reference values in cynomolgus monkeys with arrhythmia (2011)
  • Author(s): Naohide Ageyama, Hiroshi Koie, Miyoko Kato, Yasuhiro Yasutomi
  • Organizer: 62nd American Association for Laboratory Animal Science National Meeting
  • Place of Presentation: San Diego Convention Center (San Diego, CA, USA)
  • Year and Date: 2011-10-03
• [Presentation] Rare Cardiac Disease Cases in Four Cynomolgus Monkeys (Macaca fascicularis) (2011)
  • Author(s): Hiroshi Koie, Takashi Ikegawa, Sachi Okabayashi, Kiichi Kanayama, Tadashi Sankai, Yasuhiro Yasutomi, Naohide Ageyama
  • Organizer: 62nd American Association for Laboratory Animal Science National Meeting
  • Place of Presentation: San Diego Convention Center (San Diego, CA, USA)
  • Year and Date: 2011-10-03
• [Presentation] カニクイザルにおけるクレアチンキナーゼ検査系の検討 (2011)
  • Author(s): 大藤圭子、片貝祐子、加藤美代子、藤本浩二、揚山直英
  • Organizer: 第38回日本トキシコロジー学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-07-11
• [Presentation] 心磁計を用いたカニクイザルにおける電気生理学的評価システムの検討 (2011)
  • Author(s): 加藤美代子、関悠介、神鳥明彦、塚田啓二、寺尾恵治、保富康宏、揚山直英
  • Organizer: 第38回日本トキシコロジー学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-07-11
• [Presentation] 心拍変動解析を用いたカニクイザルにおける加齢性変化の検討 (2011)
  • Author(s): 川嶋晴子、鯉江洋、岡林佐知、金山喜一、山海直、保富康宏、揚山直英
  • Organizer: 第38回日本トキシコロジー学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-07-11
• [Presentation] ホルター心電計を用いたカニクイザルにおける加齢性変化の解析 (2011)
  • Author(s): 川嶋晴子、鯉江洋、岡林佐知、金山喜一、山海直、保富康宏、揚山直英
  • Organizer: 第20回サル疾病ワークショップ
  • Place of Presentation: 麻布大学(神奈川)
  • Year and Date: 2011-07-02
• [Presentation] カニクイザルに認められた先天性心疾患4例における臨床経過 (2011)
  • Author(s): 池川隆、鯉江洋、岡林佐、金山喜一、山海直、保富康宏、揚山直英
  • Organizer: 第58回日本実験動物学会総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-25
• [Presentation] カニクイザルにおける椎骨心臓スケールと心胸郭比の有用性 (2011)
  • Author(s): 西川智也、鯉江洋、金山喜一、山海直、保富康宏、揚山直英
  • Organizer: 第58回日本実験動物学会総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-25
• [Presentation] Magnetocardiography in Non-human Primate (2010)
  • Author(s): Naohide Ageyama
  • Organizer: The 3rd Asian Symposium on Magnetocardiography
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2010-12-09
• [Presentation] Magnetocardiography in Non-human Primate (2010)
  • Author(s): 揚山直英
  • Organizer: The 3rd Asian Symposium on Magnetocardiography
  • Place of Presentation: 茨城県・つくば国際会議場
  • Year and Date: 2010-12-09
• [Presentation] 霊長類の循環器疾患とモデル動物開発 (2010)
  • Author(s): 揚山直英
  • Organizer: 関西実験動物研究会第107回研究会(招待講演)
  • Place of Presentation: 滋賀医大(滋賀県)
  • Year and Date: 2010-09-11
• [Presentation] 霊長類の循環器疾患とモデル動物開発 (2010)
  • Author(s): 揚山直英
  • Organizer: 関西実験動物研究会第107回研究会
  • Place of Presentation: 滋賀県・滋賀医大(招待講演)
  • Year and Date: 2010-09-11
• [Presentation] カニクイザルにおけるQTc基準に関する検討 (2010)
  • Author(s): 加藤美代子、鯉江洋、保富康宏、揚山直英
  • Organizer: 第57回日本実験動物学会総会
  • Place of Presentation: 京都テルサ(京都府)
  • Year and Date: 2010-05-13
• [Presentation] カニクイザルにおけるQTc基準に関する検討 (2010)
  • Author(s): 加藤美代子、鯉江洋、保富康宏、揚山直英
  • Organizer: 第57回日本実験動物学会総会
  • Place of Presentation: 京都府・京都テルサ
  • Year and Date: 2010-05-13
• [Presentation] Development of nonhuman primate arrhythmia model by magnetocardiography (2010)
  • Author(s): Naohide Ageyama, Yusuke Seki, Akihiko Kandori, Miyoko Kato, Keiji Tsukada, Keiji Terao, Yasuhiro Yasutomi
  • Organizer: International Conference on Biomagnetism 2010
  • Place of Presentation: Rixos Libertas(Dubrovnik, Croatia)
  • Year and Date: 2010-04-01
• [Presentation] Development of nonhuman primate arrhythmia model by magnetocardiography (2010)
  • Author(s): 揚山直英、関悠介、神鳥明彦、加藤美代子、塚田啓二、寺尾恵治、保富康宏
  • Organizer: International Conference on Biomagnetism 2010
  • Place of Presentation: Dubrovnik, Croatia
  • Year and Date: 2010-04-01
• [Presentation] Electrophysiological cardiac evaluation by magnetocardiography in nonhuman primates (2009)
  • Author(s): Naohide Ageyama, Yusuke Seki, Akihiko Kandori, Miyoko Kato, Keiji Tsukada, Yasuhiro Yasutomi, Keiji Terao
  • Organizer: 60^<th> American Association for Laboratory Animal Science National Meeting
  • Place of Presentation: Colorado Convention Center(Denver, CO, USA)
  • Year and Date: 2009-11-09
• [Presentation] Electrophysiological cardiac evaluation by magnetocardiography in nonhuman primates (2009)
  • Author(s): N Ageyama, Y Seki, A Kandori, M Kato, K Tsukada, Y Yasutomi, K Terao
  • Organizer: 60th American Association for Laboratory Animal Science National Meeting
  • Place of Presentation: Colorado Convention Center (Denver, CO, USA)
  • Year and Date: 2009-11-09
• [Presentation] 霊長類の心磁図評価手法の確立 (2009)
  • Author(s): 関悠介,神鳥明彦,揚山直英
  • Organizer: 第24回日本不整脈学会学術大会/第26回日本心電学会学術集会合同学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-07-02
• [Presentation] 霊長類心疾患モデルにおける心磁図評価 (2009)
  • Author(s): 揚山直英、関悠介、加藤美代子、神鳥明彦
  • Organizer: 第24回日本不整脈学会学術大会/第26回日本心電学会学術集会合同学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-07-02
• [Presentation] カニクイザルにおける心磁図と心電図の比較 (2009)
  • Author(s): 加藤美代子、関悠介、田原秀哲、神鳥明彦、塚田啓二、寺尾恵治、保富康宏、揚山直英
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮ソニックホール(埼玉県)
  • Year and Date: 2009-05-14
• [Presentation] カニクイザル心筋梗塞モデルにおける心磁計を用いた電気生理学的評価 (2009)
  • Author(s): 揚山直英、関悠介、田原秀哲、加藤美代子、片貝祐子、神鳥明彦、塚田啓二、保富康宏、寺尾恵治
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮ソニックホール(埼玉県)
  • Year and Date: 2009-05-14
• [Remarks]
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