| Project/Area Number |
21700452
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FURUSE Tamio The Institute of Physical and Chemical Research, マウス表現型解析開発チーム, 開発研究員 (60392106)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | AD / HD / ENU mutagenesis / Methylphenidate / 疾患モデル / 発達障害 / AD/HD / Tubala / Me thylphenidate / マウスモデル / Crinl |
|---|
| Research Abstract |
We screened mice that exhibit AD/HD like behavior in RIKEN ENU mutagenesis program. In the screening, we isolated 2 mutant lines, M-174 and M-1736, as candidates of AD/HD model. In the detailed analyses of M-174, we carried out comprehensive behavioral, pharmacological, histological, biochemical, hematological, blood biochemical tests and evaluated the mutant as an AD/HD model. Additionally, we identified a mutation in M-1736 and carried out pharmacological and histological analyses.
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