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A proposal of newly erythrocyte deformability based on multiple mechanical properties with an experimental and a theoretical

Research Project

Project/Area Number 21700468
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo National College of Technology

Principal Investigator

YASUDA Toshitaka  東京工業高等専門学校, 電子工学科, 准教授 (90318163)

Co-Investigator(Renkei-kenkyūsha) TAKATANI Setsuo  東京医科歯科大学, 生体材料工学研究所・人工臓器部, 教授 (40154786)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsバイオメカニクス / 赤血球変形能 / レオメータ / レオロジー / 周期的せん断応力負荷 / レオメータ法 / せん断応力
Research Abstract

Erythrocyte deformability is affected to custom of daily life related on meal and fitness. An evaluation of erythrocyte deformability would be expected to be a diagnosis method ofmetabolic syndrome. In this study, a newly prototype of shear stressor which is subjectederythrocytes to periodic shear stress is developed and a theory of mechanical propertymodel for estimation of erythrocyte deformability is proposed. It is clarified that the newlyshear stress and the erythrocyte impedance model is possible to indicate the erythrocytedeformability.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009 Other

All Presentation (17 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 逆レオメータ法を用いた赤血球変形能推定システムの開発2011

    • Author(s)
      安田利貴, 横山直幸, 高谷節雄
    • Organizer
      第49回日本人工臓器学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 逆レオメータ法を用いた赤血球の力学特性推定法に関する検討2011

    • Author(s)
      安田利貴, 横山直幸, 高谷節雄
    • Organizer
      第11回生活支援工学系学会連合大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 逆レオメータ法を基礎とした周期的せん断速度負荷装置の開発2011

    • Author(s)
      安田利貴, John Gates, 横山直幸, 高谷節雄
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 連続流補助循環に伴う赤血球変形能と抗溶血特性の変化に関するin-vivo評価2011

    • Author(s)
      横山直幸, 迫田大輔, 長岡英気, 安田利貴, 高谷節雄
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 逆レオメ-タ法を用いた赤血球変形能推定システムの開発2011

    • Author(s)
      安田利貴,横山直幸,高谷節雄
    • Organizer
      第49日本人工臓器学会大会
    • Related Report
      2011 Final Research Report
  • [Presentation] 逆レオメータ法を用いた赤血球の力学特性推定法に関する検討2011

    • Author(s)
      安田利貴,横山直幸,高谷節雄
    • Organizer
      第11回生活支援工学系学会連合大会
    • Related Report
      2011 Final Research Report
  • [Presentation] 逆レオメータ法を基礎とした周期的せん断速度負荷装置の開発2011

    • Author(s)
      安田利貴, John Gates,横山直幸,高谷節雄
    • Organizer
      第50回日本生体医工学会大会
    • Related Report
      2011 Final Research Report
  • [Presentation] 連続流補助循環に伴う赤血球変形能と抗溶血特性の変化に関するin-vivo評価2011

    • Author(s)
      横山直幸,迫田大輔,長岡英気,安田利貴,高谷節雄
    • Organizer
      第50回日本生体医工学会大会
    • Related Report
      2011 Final Research Report
  • [Presentation] Age Dependent Deformability Changes of RBCs Evaluated using a Cyclically Reversing Shear Flow Generator2010

    • Author(s)
      Naoyuki Yokoyama, Daisuke Sakota, Toshitaka Yasuda, Setsuo Takatani
    • Organizer
      Biophysical Society 54th Annual Meeting
    • Place of Presentation
      California, USA
    • Year and Date
      2010-02-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Age Dependent Dynamic Deformability of RBCs Evaluated using a Cyclically Reversing Shear Flow Generator2010

    • Author(s)
      横山直幸,迫田大輔,安田利貴,高谷節雄
    • Organizer
      第49回日本生体医工学会大会
    • Related Report
      2011 Final Research Report
  • [Presentation] Age Dependent Deformability Changes of RBCs Evaluated using a Cyclically Reversing Shear Flow Generator2010

    • Author(s)
      N. Yokoyama, D. Sakota, T. Yasuda, S. Takatani
    • Organizer
      Biophysical Society 54th Annual Meeting Abstract
    • Place of Presentation
      San Francisco, California, USA.
    • Related Report
      2011 Final Research Report
  • [Presentation] 血球粘弾特性推定法に関する基礎的研究2009

    • Author(s)
      安田利貴, 中本順一, 横山直幸, 高谷節雄, 斉藤俊
    • Organizer
      第48回日本生体医工学会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 機械的せん断による赤血球の形態学的特性変化の定量化に関する研究2009

    • Author(s)
      横山直幸, 安田利貴, 斉藤俊, 高谷節雄
    • Organizer
      第48回日本生体医工学会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Age Dependent Deformability Changes of RBCs Evaluated using a Cyclically Reversing Shear Flow Generator2009

    • Author(s)
      Naoyuki Yokoyama, Daisuke Sakota, Toshitaka Yasuda, Nobuo Watanabe, Setsuo Takatani
    • Organizer
      The4th international symposium on Biomechanics in Vascular Biology and Cardiovascular Disease
    • Place of Presentation
      Rotterdam, Holland
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Age Dependent Deformability Changes of RBCs Evaluated using a Cyclically Reversing Shear Flow Generator2009

    • Author(s)
      N. Yokoyama, D. Sakota, T. Yasuda, N. Watanabe, S. Takatani
    • Organizer
      The 4th international symposium on Biomechanics in Vascular Biology and Cardiovascular Disease
    • Place of Presentation
      Rotterdam, Holland
    • Related Report
      2011 Final Research Report
  • [Presentation] 赤血球粘弾性推定法に関する基礎的研究2009

    • Author(s)
      安田利貴,中本順一,横山直幸,高谷節雄,斉藤俊
    • Organizer
      第48回日本生体医工学会大会
    • Related Report
      2011 Final Research Report
  • [Presentation] 機械的せん断による赤血球の形態学的特性変化の定量化に関する研究2009

    • Author(s)
      横山直幸,安田利貴,斉藤俊,高谷節雄
    • Organizer
      第48回日本生体医工学会大会
    • Related Report
      2011 Final Research Report
  • [Remarks] 赤血球の柔らかさの定量化,日本経産業新聞,2011年12月20日

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞用力学負荷装置2011

    • Inventor(s)
      安田利貴
    • Industrial Property Rights Holder
      高専機構
    • Industrial Property Number
      2011-016532
    • Filing Date
      2011-01-28
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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