| Project/Area Number |
21700522
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
GUO Qi Tohoku University, 大学院・医学系研究科, 非常勤講師 (50509544)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 運動 / インスリン抵抗性 / 骨格筋 / 腎不全 / アンジオテンシンII受容体拮抗薬 / AGEs / Methylglyoxal / カルボニルストレス / リハビリテーション / 高血圧 |
|---|
| Research Abstract |
Advanced glycation endproducts (AGEs) plays a pivotal role in the development of diabetes, hypertension and renal injury. Our results have demonstrated that exercise training or AGE inhibitor have effects on the hypertension, insulin resistance and renal injury, furthermore, additive effects of exercise training to AGE inhibitor were shown. The mechanisms of these effects could have involved in the rennin angiotensin system, oxidative stress, and skeletal muscle capillary network.
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