Clarification of molecular mechanism in prevention of muscular atrophy by transient blood flow restriction.
Project/Area Number |
21700548
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Juntendo University |
Principal Investigator |
KAKEHI Saori Juntendo University, 医学部, 研究員 (00450560)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 筋萎縮 / インスリン抵抗性 / 不活動 / 骨格筋 |
Research Abstract |
Transient blood flow restriction prevents muscular atrophy and weakness induced by chronic unloading. However, it was unclear which molecular mechanism. In cultured C2C12 myotube, the mRNA level of ubiquitin ligase atrogin-1・MuRF1 and the decreasing of diameter were inhibited by hypoxic stimulation at hydrogen peroxide -induced muscle atrophy model. On the other hand, the amount of insulin stimulated glucose uptake was decreased by 24 hours hind limb fixation.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men.
Author(s)
Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
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Journal Title
J Diabetes Invest. in press
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[Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men
Author(s)
Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
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Journal Title
J Diabetes Invest
Volume: (In press)
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Peer Reviewed
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[Presentation] Susceptible Factors for Intramyocellular Lipid Accumulation by Dietary Fat Loading in Non-Obese Men2010
Author(s)
Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Ikeda S, Kakehi S, Katamoto S, Naito H, Saga N, Ogura Y, Hirose T, Fujitani Y, Watada H
Organizer
American Diabetes Association 70^<th> Scientific sessions
Place of Presentation
Orlando
Related Report
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[Presentation] ヒトにおける高脂肪食負荷が骨格筋細胞内脂質蓄積とインスリン感受性に与える影響とその規定因子の解明2010
Author(s)
櫻井裕子, 田村好史, 竹野景海, 熊代尚紀, 佐藤文彦, 池田真一, 筧佐織, 形本静夫, 内藤久士, 小倉裕司, 佐賀典生, 弘世貴久, 綿田裕孝, 河盛隆造
Organizer
第53回日本糖尿病学会年次学術集会
Place of Presentation
岡山県岡山市
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