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Analysis of brain-protein profiles involved in the brain function which is preserved and enhanced by muscle activity.

Research Project

Project/Area Number 21700655
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionOsaka University

Principal Investigator

OKE Yoshihiko  Osaka University, 医学系研究科, 助教 (50396470)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords運動とトレーニング / プロテオミクス / 筋活動 / 脳機能 / プロテオミスク / MS / 後肢懸垂 / 海馬
Research Abstract

It is common knowledge that exercise, especially muscle activities of inferior limbs, can have an adverse effect on cognitive function of the brain. In this research, I investigated effects of muscle activities on cellular or molecular mechanism involved in maintaining and progress of the brain function. In order to inhibit the antigravitational muscle activities, I used hindlimb-suspended rats. The results from water maze test suggest that learning and memory capacity might be impaired by the hindlimb suspension. Furthermore, 2-dementional electrophoresis revealed that the hindlimb suspension could alter the protein expression levels and/or the modification of proteins in the hippocampus, involved in cellular protection, cell death, neurogenesis, neural activities and formation of the neuronal circuit.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009

All Presentation (8 results)

  • [Presentation] Effect of antigravity muscle activity on learning capacity and hippocampal protein expression in juvenile rats2010

    • Author(s)
      Y.Oke, F.Kawano, S.Nomura, T.Ohira, R.Fujita, N.Nakai, Y.Ohira
    • Organizer
      Experimental Biology 2010,Poster session
    • Place of Presentation
      Anaheim,California, USA.
    • Year and Date
      2010-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of antigravity muscle activity on learning capacity and hippocampal protein expression in juvenile rats2010

    • Author(s)
      Yoshihiko Oke
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim Convention Center(カリフォルニア州)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発育期ラットの記憶学習能力ならびに海馬蛋白質の発現へ後肢懸垂が及ぼす影響2009

    • Author(s)
      尾家慶彦,河野史倫,野村幸子,大平宇志,藤田諒,大平充宣
    • Organizer
      第55回日本宇宙航空環境医学会大会
    • Place of Presentation
      (口頭発表)
    • Year and Date
      2009-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 発育期ラットの記憶学習能力ならびに海馬蛋白質の発現へ後肢懸垂が及ぼす影響2009

    • Author(s)
      尾家慶彦
    • Organizer
      第55回日本宇宙航空環境医学会大会
    • Place of Presentation
      岐阜県県民文化ホール未来会館(岐阜県)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 幼年期ラットにおける後肢懸垂が記憶学習能力へ及ぼす影響2009

    • Author(s)
      尾家慶彦,河野史倫,中井直也,大平充宣
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      (口頭発表)
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 幼年期ラットにおける後肢懸垂が記憶学習能力へ及ぼす影響2009

    • Author(s)
      尾家慶彦
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター(新潟県)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of hindlimb suspension on learning capacity in juvenile rats2009

    • Author(s)
      Y.Oke, F.Kawano, T.Ohira, S.Nomura, M.Terada, N.Nakai, Y.Ohira
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences,). Poster session
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of hindlimb suspension on learning capacity in juvenile rats2009

    • Author(s)
      Yoshihiko Oke
    • Organizer
      The 36th Congress of the International Union of Physiological Science
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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