Analysis of brain-protein profiles involved in the brain function which is preserved and enhanced by muscle activity.
| Project/Area Number |
21700655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Osaka University |
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Principal Investigator |
OKE Yoshihiko Osaka University, 医学系研究科, 助教 (50396470)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 運動とトレーニング / プロテオミクス / 筋活動 / 脳機能 / プロテオミスク / MS / 後肢懸垂 / 海馬 |
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| Research Abstract |
It is common knowledge that exercise, especially muscle activities of inferior limbs, can have an adverse effect on cognitive function of the brain. In this research, I investigated effects of muscle activities on cellular or molecular mechanism involved in maintaining and progress of the brain function. In order to inhibit the antigravitational muscle activities, I used hindlimb-suspended rats. The results from water maze test suggest that learning and memory capacity might be impaired by the hindlimb suspension. Furthermore, 2-dementional electrophoresis revealed that the hindlimb suspension could alter the protein expression levels and/or the modification of proteins in the hippocampus, involved in cellular protection, cell death, neurogenesis, neural activities and formation of the neuronal circuit.
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Report
(3 results)
Research Products
(8 results)
