Intestinal tract dysfunction and skeletal muscle regeneration mechanism

• Project/Area Number: 21700687
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Ritsumeikan University (2010-2011); Tohoku University (2009)
• Principal Investigator: MATSUO Kaori 立命館大学, スポーツ健康科学部, 助教 (60513570)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: スポーツ免疫学 / 腸内細菌 / 骨格筋損傷 / 腸管機能 / 免疫組織化学染色法

Research Abstract

To investigate the contribution of commensal bacteria to the recovery of damaged skeletal muscle. It was examined whether probiotics administration may facilitate recovery of skeletal muscle tissue from damage in older animals in which muscle regeneration is compromised. These results suggest that components of commensal bacterial such as LPS favor the recovery of skeletal muscle from muscle damage. Moreover, probiotics favor the recovery of skeletal muscle from muscle damage in older adult mouse.

Research Products

• [Journal Article] Cysteinyl leukotrienes enhance the degranulation of bone marrow-derived mast cells through the autocrine mechanism (2009)
  • Author(s): I. Kaneko, K. Suzuki, K. Matsuo, H. Kumagai, Y. Owada, N. Noguchi, T. Hishinuma, M. Ono.
  • Journal Title: Tohoku J. Exp. Med. Tohoku University Volume: 3(217) Pages: 185-191
  • NAID: 10025105179
  • Peer Reviewed
• [Journal Article] Female scent mobilizes leukocytes to airways in BALB/c male mice (2009)
  • Author(s): Ekatherina A. Litvinova., Mikhail P. Moshikin., Ludmila A., Gerlinskaya, R. Nagatomi., X. Zhang., K. Matsuo., S. Shikano.
  • Journal Title: Integrative Zoology Volume: 4 Pages: 285-293
  • Peer Reviewed
• [Journal Article] Immunological parameters as a measure for physical condition of athletes-Alterations in circulating nutrophils and lymphocytes of long distance runners- (2009)
  • Author(s): K. Matsuo, R. Nagatomi
  • Journal Title: Sysmex Journal Web Volume: Vol.10.No.2 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Acute stress-induced colonic tissue HSP70 expression requires commensal bacterial components and intrinsic glucocorticoid (2009)
  • Author(s): K. Matsuo, X. Zhang, Y. Ono, R. Nagatomi
  • Journal Title: Brain, Behavior, and Immunity Volume: Vol.23 Pages: 108-115
  • NAID: 110007127019
  • Peer Reviewed
• [Journal Article] The association of the blood lymphocytes to neutrophils ratio with overtraining in endurance athletes (2009)
  • Author(s): K. Matsuo, M. Kubota, H. Sasaki, J. Toyooka, R. Nagatomi
  • Journal Title: Int. Association of Athletics Pages: 23-29
  • Peer Reviewed
• [Journal Article] スポーツ選手のコンディショニング指標としての免疫-長距離選手のコンディションと末梢血好中球・リンパ球の変動- (2009)
  • Author(s): 松生香里、永富良一
  • Journal Title: Sysmex Journal Web 10巻 Pages: 1-8
  • Peer Reviewed
• [Presentation] 高強度間欠的水泳トレーニングにおける大腸がん予防効果 (2011)
  • Author(s): 松生香里、街勝憲、劉辛、田畑泉
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 海峡メッセ下関(山口県)
  • Year and Date: 2011-09-18
• [Presentation] 高強度間欠的水泳トレーニングにおける大腸がん予防効果 (2011)
  • Author(s): 松生香里、街勝憲、劉辛、田畑泉
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 山口県(海峡メッセ下関)(ポスター発表)
  • Year and Date: 2011-09-18
• [Presentation] Ingestion of lactobacillus casei contribute regeneration of sk eletal muscle in older adult mouse (2011)
  • Author(s): K. Matsuo, M. Fujita, I. Tabata, R. Nagatomi.
  • Organizer: 10th International Society of Exerci se and Immunology
  • Place of Presentation: オックスフォード(イギリス)
  • Year and Date: 2011-07-13
• [Presentation] Ingestion of lactobacillus casei contribute regeneration of skeletal muscle in older adult mouse (2011)
  • Author(s): Kaori Matsuo, Motoo Fujita, Izumi Tabata, Ryoichi Nagatomi
  • Organizer: 10_<th> International Society of Exercise and Immunology
  • Place of Presentation: イギリス(オックスフォード)
  • Year and Date: 2011-07-13
• [Presentation] High-intensity intermittent swimming training reduces DMH-induced aberrant crypt foci in rat colon (2011)
  • Author(s): K. Matsuo, K. Tsuji, X. Liu, I. Tabata
  • Organizer: European College of Sport Science
  • Place of Presentation: リバプール(イギリス)
  • Year and Date: 2011-07-09
• [Presentation] High-intensity intermittent swimming training reduces DMH-induced aberrant crypt foci in rat colon (2011)
  • Author(s): Kaori Matsuo, Katsunori Tsuji, Liu Xin, Izumi Tabata
  • Organizer: European College of Sport Science
  • Place of Presentation: イギリス(リバプール)
  • Year and Date: 2011-07-09
• [Presentation] 末梢血リンパ球・好中球比率を指標とした選手のコンディショニング-女子中長距離選手の例 (2010)
  • Author(s): 松生香里、久保田眞由美、佐々木弘志、永富良一
  • Organizer: 第23回日本トレーニング科学会
  • Place of Presentation: 福岡大学(福岡県)
  • Year and Date: 2010-12-19
• [Presentation] 末梢血リンパ球・好中球比率を指標とした選手のコンディショニング-女子中長距離選手の例- (2010)
  • Author(s): 松生香里、久保田眞由美、佐々木弘志、永富良一
  • Organizer: 第23回日本トレーニング科学会
  • Place of Presentation: 福岡大学(福岡県)(ポスター発表)
  • Year and Date: 2010-12-19
• [Presentation] 骨格筋の損傷・再生過程におけるプロバイオティクス(Lactobacillus casei)摂取の効果 (2010)
  • Author(s): 松生香里、藤田基生、田畑泉、永富良一
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉商科大学(千葉県)
  • Year and Date: 2010-09-17
• [Presentation] 骨格筋の損傷・再生過程におけるプロバイオティクス(Lactobacillus casei)摂取の効果 (2010)
  • Author(s): 松生香里、藤田基生、田畑泉、永富良一
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉商科大学(千葉県)(口頭発表)
  • Year and Date: 2010-09-17
• [Presentation] Commensal bacteria are required for the regeneration of damaged skeletal muscle (2010)
  • Author(s): K. Matsuo, M. Fujita, R. Nagatomi.
  • Organizer: Experimental Biology 2010
  • Place of Presentation: アナハイム(アメリカ)
  • Year and Date: 2010-04-26
• [Presentation] Commensal bacteria are required for the regeneration of damaged skeletal muscle (2010)
  • Author(s): Kaori MATSUO, Motoo FUJITA, Ryoichi NAGATOMI
  • Organizer: Experimental Biology 2010.
  • Place of Presentation: アナハイムコンベンションセンター(アメリカ)(ポスター発表)
  • Year and Date: 2010-04-26
• [Presentation] Elimination of commensal bacteria delays the recovery of da maged skeletal muscle (2009)
  • Author(s): K. Matsuo, Z. Xiumin, Y. Ono, R. N agatomi.
  • Organizer: Internationa l Society of Exercise and Immunolo gy
  • Place of Presentation: テュービンゲン(ドイツ)
  • Year and Date: 2009-09-21
• [Presentation] Elimination of commensal bacteria delays the recovery of damaged skeletal muscle (2009)
  • Author(s): 松生香里、藤田基生、永富良一
  • Organizer: International Society of Exercise and Immunology(国際運動免疫学会)
  • Place of Presentation: テュービンゲン・ドイツ
  • Year and Date: 2009-09-21
• [Presentation] 骨格筋の損傷・再生過程における腸内細菌の重要性について (2009)
  • Author(s): 松生香里、藤田基生、永富良一
  • Organizer: 日本体力医学会
  • Place of Presentation: 朱鷺メッセ(新潟)
  • Year and Date: 2009-09-18
• [Presentation] 骨格筋の損傷・再生過程における腸内細菌の重要性について (2009)
  • Author(s): 松生香里、藤田基生、永富良一
  • Organizer: 日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-18
• [Book] 第15章:運動と免疫.「粘膜上皮における感染防御 (2010)
  • Author(s): 宮村実晴
  • Total Pages: 462
  • Publisher: 真興交易出版株式会社
• [Book] 運動生理学のニューエビデンス(第15章「運動と免疫.粘膜上皮における感染防御」) (2010)
  • Author(s): 宮村実晴編集.第15章-2:松生香里担当
  • Total Pages: 461
  • Publisher: 真興交易(株)医書出版部