Design of a bioreductively-activated fluorescent probe for tumor hypoxia imaging
| Project/Area Number |
21710232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto University (2010-2011)
The University of Tokushima (2009) |
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Principal Investigator |
NAKATA Eiji 京都大学, エネルギー理工学研究所, 講師 (70467827)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ケミカルバイオロジー / バイオイメージングプローブ / 蛍光イメージング / 蛍光プローブ / 蛍光強度変化 / 蛍光波長変化 / ナノ集合体 / 酵素反応 / 細胞内動態 / 細胞取り込み過程 / 細胞内pHプローブ / 標的特異的検出 / 酵素反応アッセイ / 癌低酸素環境 / 癌低pH環境 |
|---|
| Research Abstract |
Rational design methodology of the novel fluorescent probe to detect the enzymatic activity not only in test tube but also in cell was developed. For example, the fluorescent probe which could be activated in the bioreductive condition can detect the tumor hypoxia. The fluorescent probe showed clear differences in fluorescence behavior between hypoxic and aerobic conditions in the live cell.
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Report
(4 results)
Research Products
(108 results)
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[Journal Article] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo2011
Author(s)
Chiaki Abe, Yoshihiro Uto, Takashi Nakae, Yuuya Shinmoto, Keiichiro Sano, Hiroko Nakata, Mizue Teraoka, Yoshio Endo, Hiroshi Maezawa, Shin-ichiro Masunaga, Eiji Nakata and Hitoshi Hori
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Journal Title
Journal of Radiation Research
Volume: 52
Issue: 2
Pages: 208-214
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
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[Journal Article] 次世代動物実験系としての腫瘍移植鶏卵の構築と放射線照射による腫瘍成長阻害活性2009
Author(s)
安部千秋, 宇都義浩, 遠藤良夫, 新元優也, 中島宏一郎, 佐野圭一郎, 佐々木有紀, 皆巳和賢, 前澤博, 増永慎一郎, 中田栄司, 堀均
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Journal Title
放射線生物研究
Volume: Vol.44, No.2
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[Presentation]2011
Author(s)
西口泰裕・中田栄司・森井孝
Organizer
生体関連化学部会若手の会23回サマースクール
Place of Presentation
広島
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