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Study of the mechanisms underlying stress vulnerability and emotional response in aging

Research Project

Project/Area Number 21730609
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental psychology
Research InstitutionFujita Health University (2010)
National Institute for Longevity Sciences,NCGG (2009)

Principal Investigator

SHOJI Hirotaka  Fujita Health University, 総合医科学研究所, CREST研究員 (00466278)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords加齢 / ストレス / 行動 / 情動 / 前頭前野 / 扁桃体 / 縫線核 / 網羅的行動テストバッテリー / マウス / 学習・記憶 / 情動行動 / ストレス脆弱性 / 神経伝達物質
Research Abstract

The present study examined the brain mechanisms underlying stress vulnerability and emotional response in aging. Behavioral analysis indicated that aged rats and mice showed increased anxiety-like behavior and deficits in cognitive functions compared to young animals. Chronic stress induced further increase in anxiety-like behavior and stress hormone response in aged animals but not in young ones. Histochemical and neurochemical analyses indicated that aged rats might have neurotransmission dysfunction in the brain circuit involved in the stress and emotional responses. These results suggest that aging induces the vulnerability to stress with accompanying high anxiety and is associated with the changes in the underlying brain mechanisms.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Aging-related changes in the effects of social isolation on social behavior in rats.2011

    • Author(s)
      Hirotaka Shoji, Kazushige Mizoguchi.
    • Journal Title

      Physiology & Behavior 102

      Pages: 58-62

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aging-related changes in the effects of social isolation on social behavior in rats2011

    • Author(s)
      Hirotaka Shoji
    • Journal Title

      Physiology and Behavior

      Volume: 102 Pages: 58-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute and repeated stress differentially regulates behavioral, endocrine, neural parameters relevant to emotional and stress response in young and aged rats.2010

    • Author(s)
      Hirotaka Shoji, Kazushige Mizoguchi.
    • Journal Title

      Behavioural Brain Research 211

      Pages: 169-177

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute and repeated stress differentially regulates behavioral, endocrine, neural parameters relovant to emotional and stress response in young and aged rats.2010

    • Author(s)
      Shoji, H., Mizoguchi, K.
    • Journal Title

      Behavioural Brain Research 211

      Pages: 169-177

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝子改変マウスの行動表現型データベースを用いた行動に及ぼす実験時刻・加齢要因の影響の検討2010

    • Author(s)
      昌子浩孝・高雄啓三・服部聡子・遠山桂子・中西和男・宮川剛
    • Organizer
      日本動物心理学会
    • Place of Presentation
      帝京大学
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 情動行動と内分泌反応を指標とした老齢ラットのストレス脆弱性とその脳内機構の検討2009

    • Author(s)
      昌子浩孝・溝口和臣
    • Organizer
      日本動物心理学会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2009-09-26
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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