Creation of novel silyl photosensitizer absorbed on nanoparticle for photodynamic therapy
Project/Area Number |
21750133
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Functional materials chemistry
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Research Institution | Gunma University |
Principal Investigator |
HORIUCHI Hiroaki Gunma University, 大学院・工学研究科, 助教 (00334136)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 光線力学療法 / 一重項酸素 / ケイ素 / 光増感剤 / ナノ粒子 / 光増感色素 / ナノ材料 / 光物性 / 癌 |
Research Abstract |
Developments of photosensitizer for photodynamic therapy were carried out. New silyl-photosensitizer shows higher sensitization efficiency of singlet oxygen and higher cellular uptake efficiency than previous one. The silylation also improved the selectively accumulating efficiency to tumor. Photodynamic activity for tumor-bearing mice was significantly enhanced by the silylation. Hybridization of a silyl-photosensitizer with silica nanoparticle was carried out to improve the selectively accumulating efficiency to tumor. It was confirmed that the hybrid material shows high sensitization efficiency of singlet oxygen in organic solvent.
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Report
(3 results)
Research Products
(57 results)
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[Journal Article] Suppression mechanism of the photodegradation of J-aggregate thin films of cyanine dyes by coating with polysilanes2011
Author(s)
Horiuchi, H., Ishida, S., Matsuzaki, K., Tani, K., Hashimoto, T., Hotta, H., Tsunoda, K., Kodaira, T., Okutsu, T., Hiratsuka, H.
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Journal Title
J.Phys.Chem.C 115(14)
Pages: 6902-6909
Related Report
Peer Reviewed
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[Journal Article] Singlet molecular oxygen generation by water-soluble phthalocyanine dendrimers with different aggregation behavior2011
Author(s)
Nishida, M., Horiuchi, H., Momotake, A., Nishimura, Y., Hiratsuka, H., Arai, T.
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Journal Title
J.Porphyr.Phthalocyanines 15(1)
Pages: 47-53
Related Report
Peer Reviewed
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[Journal Article] Suppression mechanism of the photodegradation of J-aggregate thin films of cyanine dyes by coating with polysilanes2011
Author(s)
Horiuchi, H.; Ishida, S.; Matsuzaki, K.; Tani, K.; Hashimoto, T.; Hotta, H.; Tsunoda, K.; Kodaira, T.; Okutsu, T.; Hiratsuka, H.
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Journal Title
J.Phys.Chem.C
Volume: 115(14)
Pages: 6902-6909
Related Report
Peer Reviewed
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[Journal Article] Effects of the Substituents on 4'-Position on the Photon-mode Erasable Photochromic System of 2-Hydroxychalcone Derivatives2009
Author(s)
Horiuchi, H., Tsukamoto, A., Okajima, T., Shirase, H., Okutsu, T., Matsushima, R., Hiratsuka, H.
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Journal Title
J.Photochem.Photobiol.A 205
Pages: 203-209
Related Report
Peer Reviewed
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[Journal Article] Silylation Enhancement of Photodynamic Activity of Tetraphenylporphyrin Derivative
Author(s)
Horiuchi, H., Kameya, T., Hosaka, M.Yoshimura, K., Kyushin, S., Matsumoto, H., Okutsu, T., Takeuchi, T., Hiratsuka, H.
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Journal Title
J.Photochem.Photobiol.A in press.
Related Report
Peer Reviewed
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[Presentation] Development of Silicon-containing Photosensitizer for Photodynamic Thera py2010
Author(s)
Horiuchi, H., Kameya, T., Yoshimuta, K.,Kyushin, S.,Matsumoto, H.,Hosaka, M., Takeuchi, T.,Okutsu, T.,Hiratsuka, H.
Organizer
PacifiChem 2010
Place of Presentation
Haw aii(USA)
Year and Date
2010-12-19
Related Report
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[Presentation] Development of Silicon-containing Photosensitizer for Photodynamic Therapy2010
Author(s)
Horiuchi, H.; Kameya, T.; Yoshimura, K.; Kyushin, S.; Matsumoto, H.; Hosaka, M.; Takeuchi, T.; Okutsu, T.; Hiratsuka, H.
Organizer
PacifiChem 2010
Place of Presentation
Hawaii, USA
Year and Date
2010-12-19
Related Report
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