Preparation of Intelligent Gel by the Formation of Polyion Complex with Alternative Immersion Approach

• Project/Area Number: 21750220
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Polymer/Textile materials
• Research Institution: Osaka University
• Principal Investigator: AJIRO Hiroharu 大阪大学, 臨床医工学融合研究教育センター, 特任准教授(常勤) (50437331)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ゲル / 薬物伝達システム / 薬物送達システム / 交互浸漬法 / ポリイオンコンプレックス / N-ビニルアセトアミド / N-ビニルホルムアミド / ポリビニルアミン / 相互侵入網目構造

Research Abstract

Taking advantage of different solubility of poly(vinylamine) and poly(N-vinylamide) s, surface-cationized gel was prepared by applying layer-by-layer approach. The second polymer network was introduced into the gel to obtain the" surface polyion complex gel(sPIC gel)", which only surface moiety is responsive to the circumstance change. sPIC gel suppressed neutral polymer at pH 7 and anionic low molecules, respectively.

Research Products

• [Journal Article] Thermosensitive Biodegradable Homopolymer of Trimethylene Carbonate Derivative at Body Temperature (2012)
  • Author(s): Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi
  • Journal Title: Macromolecules Volume: 45(6) Pages: 2668-2674
• [Journal Article] Radical Polymerization of Novel N-Substituted-N-vinylformamide Derivatives with Bulky Chiral Substituents (2012)
  • Author(s): Hiroharu Ajiro, Mitsuru Akashi
  • Journal Title: J. Polym. Sci. Part A : Polym. Chem Volume: 50(1) Pages: 134-141
• [Journal Article] Radical Polymerization of Novel N-Substituted-N-vinylformamide Derivatives with Bulky Chiral Substituents (2012)
  • Author(s): Hiroharu Ajiro, Mitsuru Akashi
  • Journal Title: J.Polym.Sci.Part A : Polym.Chem. Volume: 50 Issue: 1 Pages: 134-141
  • DOI: 10.1002/pola.25012
  • Peer Reviewed
• [Journal Article] Interpenetrating Polymer Networks of Poly(N-vinylacetamide) and Stimuli Responsive Polymers Applied to Novel Amphiphilic Gel (2011)
  • Author(s): Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
  • Journal Title: J. Nanosci. Nanotech Volume: 11(8) Pages: 7047-7049
• [Journal Article] Fabrication of Surface-Modified Hydrogels with Polyion Complex for Controlled Release (2010)
  • Author(s): Yukie Takemoto, Hiroharu Ajiro, Taka-aki Asoh, Mitsuru Akashi
  • Journal Title: Chem. Mater Volume: 22(9) Pages: 2923-2929
• [Journal Article] Nano Grape Formation by isotacitc-Poly(methacrylic acid)-block-poly(butyl acrylate) (2010)
  • Author(s): Hiroharu Ajiro, Mitsuru Akashi
  • Journal Title: Macromol. Rapid Commun. Volume: 31(8) Pages: 714-717
• [Journal Article] Cell Proliferation on Stereoregular isotactic-Poly(propylene oxide) as a Bulk Substrate (2010)
  • Author(s): Hiroharu Ajiro, Mitsuru Akashi
  • Journal Title: Biomacromolecules Volume: 11(11) Pages: 2840-2844
• [Journal Article] Fabrication of Surface-Modified Hydrogels with Polyion Complex for Controlled Release (2010)
  • Author(s): Yukie Takemoto, Hiroharu Ajiro, Taka-aki Asoh, Mitsuru Akashi
  • Journal Title: Chem.Mater. Volume: 22 Pages: 2923-2929
  • Peer Reviewed
• [Journal Article] Nano Grape Formation by isotacitc-Poly(methacrylic acid)-block-poly(butyl acrylate) (2010)
  • Author(s): Hiroharu Ajiro, Mitsuru Akashi
  • Journal Title: Macromol.Rapid Commun. Volume: 31 Pages: 714-717
  • Peer Reviewed
• [Journal Article] Novel Polyion Complex with Interpenetrating Polymer Network of Poly(acrylic acid) and Partially Protected Poly(vinylamine) Using N-Vinylacetamide and N-Vinylformamide (2009)
  • Author(s): Hiroharu Ajiro, Yukie Takemoto, Taka-aki Asoh, Mitsuru Akashi
  • Journal Title: Polymer Volume: 50(15) Pages: 3503-3507
• [Journal Article] Novel Polyion Complex with Interpenetrating Polymer Network of Poly (acrylic acid) and Partially Protected Poly (vinylamine) Using N-Vinylacetamide and N-Vinylformamide (2009)
  • Author(s): Hiroharu Ajiro, Yukie Takemoto, Taka-aki Asoh, Mitsuru Akashi
  • Journal Title: Polymer 50 Pages: 3503-3507
  • Peer Reviewed
• [Presentation] 高分子構造制御による新規素材探索 (2011)
  • Author(s): 網代広治
  • Organizer: 第11回次世代医工学研究会、ショートプレゼン
  • Place of Presentation: 大阪(大阪大学吹田キャンパス)
  • Year and Date: 2011-10-21
• [Presentation] 高分子構造制御による新規素材探索 (2011)
  • Author(s): 網代広治
  • Organizer: 第11回次世代医工学研究会
  • Place of Presentation: 大阪(大阪大学吹田キャンパス)
  • Year and Date: 2011-10-21
• [Presentation] ポリ(N-ビニルアミド)ゲルの表面カチオン化とポリイオンコンプレックスを利用した薬物徐放制御 (2011)
  • Author(s): 網代広治・竹村一哉・明石満
  • Organizer: 第60回高分子学会討論会
  • Place of Presentation: 岡山(岡山大学津島キャンパス)
  • Year and Date: 2011-09-28
• [Presentation] 表面ポリイオンコンプレックスゲルによる二種類の薬物徐放制御(Dual drug release system by surface polyion complex hydrogel) (2011)
  • Author(s): 網代広治・明石満
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪(大阪国際会議場)(英語口頭発表)
  • Year and Date: 2011-05-27
• [Presentation] 相互侵入網目構造を導入したポリ(N-ビニルアミド)ゲルの新規材料創製 (2011)
  • Author(s): 網代広治
  • Organizer: 高分子学会精密ネットワークポリマー研究会
  • Place of Presentation: 兵庫(兵庫県立大学姫路書写キャンパス書写記念会館)
  • Year and Date: 2011-03-08
• [Presentation] 相互侵入網目構造を導入したポリ(N-ビニルアミド)ゲルの新規材料創製 (2011)
  • Author(s): 網代広治
  • Organizer: 高分子学会精密ネットワークポリマー研究会、若手シンポジウム
  • Place of Presentation: 兵庫県立大学姫路書写キャンパス書写記念会館(招待講演)
  • Year and Date: 2011-03-08
• [Presentation] ポリ(N-ビニルアミド)ゲルの表面カチオン化とポリイオンコンプレックスを利用した薬物徐放制御 (2011)
  • Author(s): 網代広治・竹村一哉・明石満
  • Organizer: 第60回高分子学会討論会、1L11
  • Place of Presentation: 岡山(岡山大学津島キャンパス)
• [Presentation] 表面ポリイオンコンプレックスゲルによる二種類の薬物徐放制御(Dual drug release system by surface polyion complex hydrogel) (2011)
  • Author(s): 網代広治・明石満
  • Organizer: 第60回高分子学会年次大会、3L16
  • Place of Presentation: 大阪(大阪国際会議場)
• [Presentation] 立体規則性合成高分子を用いた表面修飾における構造と生体適合性評価 (2010)
  • Author(s): 網代広治・明石満
  • Organizer: 第32回日本バイオマテリアル学会大会
  • Place of Presentation: 広島(グランドプリンスホテル広島)
• [Presentation] Simple Polyion Complex Hydrogel by Poly (acrylic acid) and Partially Protected Poly (vinylamine) (2009)
  • Author(s): Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
  • Organizer: 11^<th> Pacific Polymer Conference 2009
  • Place of Presentation: Cairns Convention Centre, Cairns (Australia)
  • Year and Date: 2009-12-08
• [Presentation] 薬物放出制御のためのポリ(N-ビニルアミド)ゲルの表面改質 (2009)
  • Author(s): 竹本友紀恵・網代広治・明石満
  • Organizer: 日本バイオマテリアル学会第4回関西若手研究発表会
  • Place of Presentation: 大阪(大阪大学銀杏会館)
  • Year and Date: 2009-08-07
• [Presentation] Amphiphilic poly(N-vinylacetamide) hydrogel modified with interpenetrating network approach for transdermal therapeutic systems (2009)
  • Author(s): Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
  • Organizer: The 36th International Congress of Physiological Sciences
  • Place of Presentation: 京都(国際会館)
  • Year and Date: 2009-07-29
• [Presentation] Amphiphilic poly (N-vinylacetamide) hydrogel modified with interpe netrating network approach for transdermal therapeutic systems (2009)
  • Author(s): Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
  • Organizer: The 36th International Congress of Physiological Sciences
  • Place of Presentation: 京都(国際会館)
  • Year and Date: 2009-07-29
• [Presentation] ポリイオンコンプレックスにより表面被覆されたゲルの調製と薬物放出制御 (2009)
  • Author(s): 竹本友紀恵・網代広治・麻生隆彬・明石満
  • Organizer: 第55回高分子研究会
  • Place of Presentation: 神戸(兵庫県民会館)
  • Year and Date: 2009-07-17
• [Presentation] ポリイオンコンプレックスにより表面被覆されたゲルの調製と薬物放出制御 (2009)
  • Author(s): 竹本友紀恵・網代広治・麻生隆彬・明石満
  • Organizer: 第55回高分子研究発表会
  • Place of Presentation: 神戸(兵庫県民会館)
  • Year and Date: 2009-07-17
• [Presentation] 表面に刺激応答性ポリイオンコンプレックス膜を有するゲルの調製と薬物放出制御 (2009)
  • Author(s): 竹本友紀恵・網代広治・麻生隆彬・明石満
  • Organizer: 第58回高分子学会討論会
  • Place of Presentation: 熊本(熊本大学工学部)
  • Year and Date: 2009-07-17
• [Presentation] Simple Polyion Complex Hydrogel by Poly(acrylic acid) and Partially Protected Poly(vinylamine) (2009)
  • Author(s): Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
  • Organizer: 11th Pacific Polymer Conference 2009, PPC 11, Cairns Convention Centre
  • Place of Presentation: Cairns(Australia)
• [Presentation] 表面に刺激応答性ポリイオンコンプレックス膜を有するゲルの調製と薬物放出制御 (2009)
  • Author(s): 竹本友紀恵・網代広治・麻生隆彬・明石満
  • Organizer: 第58回高分子学会討論会、2L3-03
  • Place of Presentation: 熊本(熊本大学工学部)
• [Remarks] 研究室のホームページ
  • URL: http://www.chem.eng.osaka-u.ac.jp/~akashi-lab/member/ajiro/ajiro_profile.html
• [Remarks] 大学の個人研究者のページ
• [Remarks]
  • URL: http://www.chem.eng.osaka-u.ac.jp/~akashi-lab/Member/Ajiro/Ajiro_Achievements/Ajiro_Achievements.html
• [Remarks]
  • URL: http://www.chem.eng.osaka-u.ac.jp/~akashi-lab/Member/Ajiro/Ajiro_Achievements/Ajiro_Achievements.html