Development of mesoporous silica for removal of middle molecule uremic toxins

• Project/Area Number: 21760527
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Inorganic materials/Physical properties
• Research Institution: Tohoku University
• Principal Investigator: HOSHIKAWA Yasuto Tohoku University, 多元物質科学研究所, 助教 (90527839)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ナノ材料 / 生体材料 / メソポーラスシリカ / 炭素被覆 / 多孔性材料 / 炭素材料

Research Abstract

Selective removal of middle molecule uremic toxins is difficult in a current hemodialysis membrane. Mesoporous silica nanoparticles (MSNs) are promising as superior adsorbent for specific middle molecule with highly selectivity. Expansion of mesopore (over 6nm, the size is well suited to absorbing middle molecule) in MSNs was achieved by adding 1,3,5-trimethylbenzene and incorporating aminopropyl group in silica structure, and the silica surface of MSNs was coated by carbon thin layer (under 1nm) to improve blood compatibility and durability.

Research Products

• [Journal Article] Mesoporous Silica Nanoparticles with Remarkable Stability and Dispersibility for Antireflective Coatings (2010)
  • Author(s): Yasuto Hoshikawa, Hiroki Yabe, Atsuro Nomura, Takeyuki Yamaki, Atsushi Shimojima, Tatsuya Okubo
  • Journal Title: Chemistry of Materials 22 Pages: 12-14
  • Peer Reviewed
• [Journal Article] 高分散性メソポーラスシリカナノ粒子の合成と光学応用 (2010)
  • Author(s): 干川康人, 下嶋敦, 大久保達也, 矢部裕城, 山木健介
  • Journal Title: ゼオライト 27 Pages: 103-110
  • NAID: 40017322771
  • Peer Reviewed
• [Journal Article] 高分散性メソポーラスシリカナノ粒子の合成と光学応用 (2010)
  • Author(s): 干川康人, 下嶋敦, 大久保達也, 矢部裕城, 山木健介
  • Journal Title: ゼオライト Volume: 27 Pages: 103-110
  • NAID: 40017322771
  • Peer Reviewed
• [Journal Article] Enhancement of Corrosion Resistance of Titanium-Copper Based Metallic Glass by Methylsiloxane Coating (2009)
  • Author(s): Yasuto Hoshikawa, Eiichi Yasuda, Akihisa Inoue, 他10名略
  • Journal Title: Materials Transactions 50 Pages: 52-58
  • NAID: 10024815786
  • Peer Reviewed
• [Journal Article] Structural Control of Phenylene-bridged Periodic Mesoporous Organosilica with Organic Additives (2009)
  • Author(s): Ayumu Fukuoka, Yasuto Hoshikawa, Atsushi Shimojima, Tatsuya Okubo
  • Journal Title: Chemistry Letters 38 Pages: 1026-1027
  • NAID: 10025547671
  • Peer Reviewed
• [Journal Article] Enhancement of Corrosion Resistance of Titanium-Copper Based Metallic Glass by Methylsiloxane Coating (2009)
  • Author(s): Yasuto Hoshikawa, Eiichi Yasuda, Takashi Akatsu, Toru Onoda, Naota Sugiyama, Nobuhiro Matsushita, Takamasa Onoki, Masaru Akao, Yasuhiro Tanabe, Masahiro Yoshimura, Shengli Zhu, Xinmin Wang, Akihisa Inoue
  • Journal Title: Materials Transactions 50 Pages: 52-58
  • NAID: 10024815786
  • Peer Reviewed
• [Presentation] カーボンナノ試験管のナノ空間内でのDNA濃縮 (2010)
  • Author(s): 干川康人, 寒河江拓也, 菅野康之, 折笠広典, Somlak Ittisanronnach, 井本修平, 和田健彦, 永次史, 京谷隆
  • Organizer: 2010高分子・ハイブリッド材料研究センター若手フォーラム
  • Place of Presentation: 東北大学片平さくらホール(仙台)
  • Year and Date: 2010-12-06
• [Presentation] カーボンナノ試験管内へのDNA濃縮 (2010)
  • Author(s): 干川康人、寒河江 拓也、菅野康之、折笠広典、Somlak Ittisanronnachai、井本修平、和田健彦、永次史、京谷隆
  • Organizer: 第37回炭素材料学会年会
  • Place of Presentation: 姫路市民会館(姫路)
  • Year and Date: 2010-12-02
• [Presentation] カーボンナノ試験管へのDNA濃縮に対する金属カチオンの影響 (2010)
  • Author(s): 寒河江拓也, 干川康人, 菅野康之, Somlak Ittisanronnachai, 井本修平, 和田健彦, 永次史, 京谷隆
  • Organizer: 第10回東北大学多元物質科学研究所研究発表会
  • Place of Presentation: 東北大学片平さくらホール(仙台)
  • Year and Date: 2010-12-01
• [Presentation] Blood Compatibility and Tissue Response of Methylsiloxane Coating (2010)
  • Author(s): Yasuto Hoshikawa, Takamasa Onoki, Masaru Akao, Takashi Akatsu, Yasuhiro Tanabe, Eiichi Yasuda
  • Organizer: 3rd International Congress on Ceramics (ICC3)
  • Place of Presentation: Osaka. Japan
  • Year and Date: 2010-11-18
• [Presentation] Blood Compatibility and Tissue Response of Methylsiloxane Coating (2010)
  • Author(s): Yasuto Hoshikawa, Takamasa Onoki, Masaru Akao, Takashi Akatsu, Yasuhiro Tanabe, Eiichi Yasuda
  • Organizer: 3rd International Congress on Ceramics (ICC3)
  • Place of Presentation: Osaka.Japan
  • Year and Date: 2010-11-18
• [Presentation] カーボンナノ試験管内へのDNA濃縮とその可逆的な放出 (2010)
  • Author(s): 干川康人, 菅野康之, 折笠広典, Somlak Ittisanronnach, 井本修平, 和田健彦, 永次史, 京谷隆
  • Organizer: 平成22年度化学系学協会東北大会
  • Place of Presentation: 岩手大学工学部(盛岡)
  • Year and Date: 2010-09-26
• [Presentation] 二種の界面活性剤を用いたメソポーラスシリカナノ粒子の合成 (2010)
  • Author(s): 石井大貴, 干川康人, 下嶋敦, 大久保達也
  • Organizer: 日本ゾル-ゲル学会第8回討論会
  • Place of Presentation: 名古屋大学東山キャンパス豊田講堂(名古屋)
  • Year and Date: 2010-07-29
• [Presentation] DNA encapsulation and release from water-dispersible carbon nano-test-tubes (2010)
  • Author(s): Yasuto Hoshikawa, Yasuyuki Kanno, Hironori Orikasa, Somlak Ittisanronnach, Takehiko Wada, Fumi Nagatsugi, Takashi Kyotani
  • Organizer: Carbon 2010
  • Place of Presentation: Clemson, USA
  • Year and Date: 2010-06-13
• [Presentation] DNA ENCAPSULATION AND RELEASE FROM WATER-DISPERSIBLE CARBON NANO-TEST-TUBES[Keynote] (2010)
  • Author(s): Yasuto Hoshikawa, Yasuyuki Kanno, Hironori Orikasa, Somlak Ittisanronnach, Takehiko Wada, Fumi Nagatsugi, Takashi Kyotani
  • Organizer: Carbon 2010
  • Place of Presentation: Clemson, USA
  • Year and Date: 2010-06-13
• [Presentation] 機修飾メソポーラスシリカナノ粒子の合成と反射防止膜フィラーへの応用 (2009)
  • Author(s): 干川康人, 下嶋敦, 大久保達也, 矢部裕城, 山木健之
  • Organizer: 第19回日本MRS学術シンポジウム
  • Place of Presentation: 横浜市開港記念会館(横浜)
  • Year and Date: 2009-12-09
• [Presentation] 有機修飾メソポーラスシリカナノ粒子の合成と反射防止膜フィラーへの応用 (2009)
  • Author(s): 干川康人, 下嶋敦, 大久保達也, 矢部裕城, 山木健之
  • Organizer: 第19回日本MRS学術シンポジウム
  • Place of Presentation: 横浜市開港記念会館, 横浜
  • Year and Date: 2009-12-09
• [Presentation] メソポーラスシリカナノ粒子のトリメチルシリル化による分散安定性向上及び薄膜応用 (2009)
  • Author(s): 干川康人, 野村篤朗, 下嶋敦, 大久保達也, 矢部裕城, 山木健之
  • Organizer: 日本セラミックス協会第22回秋季シンポジウム
  • Place of Presentation: 愛媛大学城北地区(松山)
  • Year and Date: 2009-09-17
• [Presentation] メソポーラスシリカナノ粒子のトリメチルシリル化による分散安定性向上及び薄膜応用 (2009)
  • Author(s): 干川康人, 野村篤朗, 下嶋敦, 大久保達也, 矢部裕城, 山木健之
  • Organizer: 日本セラミックス協会第22回秋季シンポジウム
  • Place of Presentation: 愛媛大学(城北地区), 松山
  • Year and Date: 2009-09-17
• [Presentation] Preparation of Organically-Modified Mesoporous Silica Nanoparticles with Ethylene Glycol (2009)
  • Author(s): Yasuto Hoshikawa, Atsuro Nomura, Atsushi Shimojima, Tatsuya Okubo
  • Organizer: The Organizing Committee cordially invites you to participate in the International Symposium on Zeolites and Microporous Crystals (ZMPC2009)
  • Place of Presentation: Waseda University, Tokyo, Japan
• [Presentation] Preparation of Organically-Modified Mesoporous Silica Nanoparticles with Ethylene Glycol (2009)
  • Author(s): 干川康人, 野村篤朗, 下嶋敦, 大久保達也
  • Organizer: The Organizing Committee cordially invites you to participate in the International Symposium on Zeolites and Microporous Crystals(ZMPC2009)
  • Place of Presentation: Waseda University, Tokyo, Japan
• [Patent(Industrial Property Rights)] メソポーラスシリカ微粒子の製造方法、メソポーラスシリカ微粒子、メソポーラスシリカ微粒子分散液、メソポーラスシリカ微粒子含有組成物、及びメソポーラスシリカ微粒子含有成型物 (2010)
  • Inventor(s): 矢部裕城, 山木健之, 干川康人, 大久保達也, 下嶋敦
  • Industrial Property Rights Holder: パナソニック電工
  • Filing Date: 2010-05-18
  • Overseas
• [Patent(Industrial Property Rights)] メソポーラスシリカ微粒子の製造方法、メソポーラスシリカ微粒子、メソポーラスシリカ微粒子分散液、メソポーラスシリカ微粒子含有組成物、及びメソポーラスシリカ微粒子含有成型物 (2010)
  • Inventor(s): 矢部裕城, 山木健之, 干川康人, 大久保達也, 下嶋敦
  • Industrial Property Rights Holder: パナソニック電工
  • Filing Date: 2010-05-18
• [Patent(Industrial Property Rights)] 酸化チタン膜および酸化チタン膜形成方法 (2009)
  • Inventor(s): 赤津隆, 干川康人, 他
  • Industrial Property Rights Holder: 国立大学法人東京工業大学
  • Industrial Property Number: 2009-062153
  • Filing Date: 2009-05-01