Analysis of chromatin remodeling machinery required for the regulation of DNA replication
| Project/Area Number |
21780086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
OMA Yukako 東北大学, 大学院・農学研究科, 研究支援者 (20443997)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | クロマチン / DNA複製 / アクチン関連タンパク質 / クロマチンリモデリング複合体 / 細胞核 / アクチンファミリー / ゲノム安定性維持 / ゲノム安定性 / クロマチン構造変換 |
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| Research Abstract |
To analyze the function of the INO80 chromatin remodeling complex in DNA replication and in the maintenance of genome stability, we established Degron yeast strains in which Ino80 and Arp8 are inducibly digested. We showed that the impairment of the INO80 complex caused genome instability. We also showed physiological and genetic interactions of the INO80 complex with DNA replication factors, chromatin proteins, and nuclear pore complex. Theseresults are important to reveal molecular mechanisms of the INO80 complex in DNAreplication and the maintenance of genome stability.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot2010
Author(s)
Sun, J., Oma, Y., Harata, M., Kono, K., Shima, H., Kinomura, A., Ikura, T., Mizutani, S., Kanaarm, R., Tashiro, S
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Journal Title
PLoS One
Volume: 5
Issue: 10
Pages: e13554-e13554
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Actin-related protein Arp6 influences H2AZ-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores2010
Author(s)
Yoshida, T, Shimada, K., Oma, Y., Kalck, V., Akimura, K., Taddei, A., Iwahashi, H., Kugou, K., Ohta, K., Gasser, S.M., Harata, M
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Journal Title
PLoS Genet
Volume: 6
Issue: 4
Pages: e1000910-e1000910
DOI
Related Report
Peer Reviewed
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