| Budget Amount *help |
¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
To analyze the function of the INO80 chromatin remodeling complex in DNA replication and in the maintenance of genome stability, we established Degron yeast strains in which Ino80 and Arp8 are inducibly digested. We showed that the impairment of the INO80 complex caused genome instability. We also showed physiological and genetic interactions of the INO80 complex with DNA replication factors, chromatin proteins, and nuclear pore complex. Theseresults are important to reveal molecular mechanisms of the INO80 complex in DNAreplication and the maintenance of genome stability.
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