| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The aim of this study is to understand coordinated regulation between cell morphogenesis and cell growth in fission yeast. Although cell morphogenesis that has an essential role in expression of cellular function is properly regulated by cell cycle, the precise mechanism remains elusive. In fission yeast, the MOR pathway promotes actin polarization to cell tips in interphase, whereas the SIN pathway pathway drives actomyosin ring assembly and cytokinesis. In this study, We show that the SIN pathway inhibits MOR pathway in mitosis and this regulation is important for completion of cytokinesis and coordination of cytoskeletal remodeling at the mitosis-to-interphase transition.
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